IRC8_YEAST - dbPTM
IRC8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IRC8_YEAST
UniProt AC P47046
Protein Name Uncharacterized protein IRC8
Gene Name IRC8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 822
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MCHNSVRSGNKAGFLGIKFGSALLSIATGAIAIALLCKFHDHEAVLIVIVCSTLLYGIPSLISFITETVFAPSKFHIGYFYNVLNFALPLITMGCTVDYFHNTLRSPISVQSESHRVYITTLDSLLIFTLFINGIQLGFFLKDGNANNFGSSSNNISTDQYDKEANAVENGRFVPLKNSSQTLTPDLELLHGSPKSMNGVAWLINELSTNSNTNANKTISSDENSNSSVIRHKLGPISTSKCPKKPSHSHFSKLKKYNSFFLGPKENRYKRNTQQATKVPTEKKSNHRSSQYVSRLSTISDISKSFLNFLALNEKNGNSTSTARTPSEGRVSIIINEGNNTLKYKTPHDSHTIDSPNLELEREAIGRINSALLPACLRVTDKMISPQQSTQNEDSYQATPLIPQVEVDDDFYVGDILMTNELQDIPQVPRISSDIEDDFEQQYTKHVDLPARVTLEMWEKDQEKILQKVTTNRDKSKLLPPFRFTSESDMDPSTSTELEVELHAQNNFSFPFKSAGLQIATSDQFNQQEFKTSDTISELDEYLHDPSIQEEDASQLIESSLNQNNLSSTTIDNGPKDMSRFSTRHSPTKSIISMISGSGSVKHQHSHSTLSNFFTGHSRNNSQINQLLQGSSSNMMSNTSPHSSPTKSLRMRFGKKLSLSNISDTMSPYEGSTTDPINYSFGHGHNKNQSIDFSYVRTLQSSHSPTKSTSGNSRRDSLNNDRTQSTVNERALRTASTLFYLQHNNATCTLNGEEPVLDTPQSIQSSSSGSEQESAGSGSGYPEVVFSEYDREKWNVLRNLKEIAPEKTIESGPVEELVSPSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MCHNSVRSGNKA
---CCCCCCCCCCCC		8.6821126336
163UbiquitinationISTDQYDKEANAVEN
CCHHHHHHHHCHHCC		54.5123749301
177UbiquitinationNGRFVPLKNSSQTLT
CCEEEECCCCCCCCC		49.0323749301
179PhosphorylationRFVPLKNSSQTLTPD
EEEECCCCCCCCCCC		23.4121440633
180PhosphorylationFVPLKNSSQTLTPDL
EEECCCCCCCCCCCH		36.2621440633
182PhosphorylationPLKNSSQTLTPDLEL
ECCCCCCCCCCCHHH		34.2523749301
184PhosphorylationKNSSQTLTPDLELLH
CCCCCCCCCCHHHHC		20.3921440633
193PhosphorylationDLELLHGSPKSMNGV
CHHHHCCCCCHHHHH		20.5728152593
196PhosphorylationLLHGSPKSMNGVAWL
HHCCCCCHHHHHHHH		22.3621440633
218PhosphorylationSNTNANKTISSDENS
CCCCCCCCCCCCCCC		26.3727717283
220PhosphorylationTNANKTISSDENSNS
CCCCCCCCCCCCCCC		36.6521551504
221PhosphorylationNANKTISSDENSNSS
CCCCCCCCCCCCCCC		45.1323749301
225PhosphorylationTISSDENSNSSVIRH
CCCCCCCCCCCHHHH		35.7223749301
227PhosphorylationSSDENSNSSVIRHKL
CCCCCCCCCHHHHHC		26.2928889911
228PhosphorylationSDENSNSSVIRHKLG
CCCCCCCCHHHHHCC		26.3023749301
241UbiquitinationLGPISTSKCPKKPSH
CCCCCCCCCCCCCCC		55.4323749301
304UbiquitinationSTISDISKSFLNFLA
HHHHHHHHHHHHHHH		45.6317644757
305PhosphorylationTISDISKSFLNFLAL
HHHHHHHHHHHHHHH		28.3321440633
315UbiquitinationNFLALNEKNGNSTST
HHHHHHCCCCCCCCC		69.9117644757
327PhosphorylationTSTARTPSEGRVSII
CCCEECCCCCCEEEE		52.6623749301
332PhosphorylationTPSEGRVSIIINEGN
CCCCCCEEEEEECCC		13.5023749301
346PhosphorylationNNTLKYKTPHDSHTI
CCEEEECCCCCCCCC		23.8329688323
350PhosphorylationKYKTPHDSHTIDSPN
EECCCCCCCCCCCCC		21.3529688323
352PhosphorylationKTPHDSHTIDSPNLE
CCCCCCCCCCCCCHH		30.3629688323
355PhosphorylationHDSHTIDSPNLELER
CCCCCCCCCCHHHHH		16.3125704821
370PhosphorylationEAIGRINSALLPACL
HHHHHHHHHHHHHHH		20.2323749301
432PhosphorylationIPQVPRISSDIEDDF
CCCCCCCCCCCCHHH		24.2022890988
433PhosphorylationPQVPRISSDIEDDFE
CCCCCCCCCCCHHHH		39.9922890988
445UbiquitinationDFEQQYTKHVDLPAR
HHHHHHHHCCCCCCE		36.3817644757
476PhosphorylationVTTNRDKSKLLPPFR
HCCCCCHHHCCCCCC		32.5927017623
582PhosphorylationPKDMSRFSTRHSPTK
CCCHHHCCCCCCCCH		24.3421440633
600PhosphorylationSMISGSGSVKHQHSH
HHHCCCCCCCCCCCC		29.6821440633
622PhosphorylationTGHSRNNSQINQLLQ
CCCCCCHHHHHHHHH		35.6723749301
658PhosphorylationMRFGKKLSLSNISDT
HHHCCEEECCCCCCC		38.3321440633
660PhosphorylationFGKKLSLSNISDTMS
HCCEEECCCCCCCCC		28.8324961812
663PhosphorylationKLSLSNISDTMSPYE
EEECCCCCCCCCCCC		31.1424961812
665PhosphorylationSLSNISDTMSPYEGS
ECCCCCCCCCCCCCC		16.8621440633
667PhosphorylationSNISDTMSPYEGSTT
CCCCCCCCCCCCCCC		26.8224961812
679PhosphorylationSTTDPINYSFGHGHN
CCCCCCCCCCCCCCC		13.1927017623
680PhosphorylationTTDPINYSFGHGHNK
CCCCCCCCCCCCCCC		21.9227017623
690PhosphorylationHGHNKNQSIDFSYVR
CCCCCCCCEEEEEEE		33.2522369663
694PhosphorylationKNQSIDFSYVRTLQS
CCCCEEEEEEEEECC		20.9721440633
701PhosphorylationSYVRTLQSSHSPTKS
EEEEEECCCCCCCCC		32.8830377154
704PhosphorylationRTLQSSHSPTKSTSG
EEECCCCCCCCCCCC		35.8921440633
706PhosphorylationLQSSHSPTKSTSGNS
ECCCCCCCCCCCCCC		40.4121551504
717PhosphorylationSGNSRRDSLNNDRTQ
CCCCCCHHCCCCCHH		31.0528889911
808PhosphorylationKEIAPEKTIESGPVE
HHHCCCCEECCCCHH		28.4523749301
811PhosphorylationAPEKTIESGPVEELV
CCCCEECCCCHHHHC		44.5428152593
819PhosphorylationGPVEELVSPSK----
CCHHHHCCCCC----		35.7621551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IRC8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IRC8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IRC8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LSM12_YEASTLSM12physical
16554755
SLU7_YEASTSLU7genetic
27708008
IZH2_YEASTIZH2genetic
27708008
QCR2_YEASTQCR2genetic
27708008
SEC17_YEASTSEC17genetic
27708008
APC11_YEASTAPC11genetic
27708008
PRP9_YEASTPRP9genetic
27708008
DPOD_YEASTPOL3genetic
27708008
LCB2_YEASTLCB2genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
TFB1_YEASTTFB1genetic
27708008
KGUA_YEASTGUK1genetic
27708008
ESP1_YEASTESP1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MET30_YEASTMET30genetic
27708008
MCM10_YEASTMCM10genetic
27708008
CDC6_YEASTCDC6genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
SN114_YEASTSNU114genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SMC4_YEASTSMC4genetic
27708008
LCB1_YEASTLCB1genetic
27708008
LIP1_YEASTLIP1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
ULP1_YEASTULP1genetic
27708008
MOT1_YEASTMOT1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
ARP7_YEASTARP7genetic
27708008
PSB5_YEASTPRE2genetic
27708008
NUP60_YEASTNUP60genetic
27708008
AVT5_YEASTAVT5genetic
27708008
QOR_YEASTZTA1genetic
27708008
MCM21_YEASTMCM21genetic
27708008
SHE9_YEASTSHE9genetic
27708008
SNF1_YEASTSNF1genetic
27708008
METK2_YEASTSAM2genetic
27708008
RT31_YEASTYMR31genetic
27708008
GEP7_YEASTGEP7genetic
27708008
XRN1_YEASTXRN1genetic
27708008
ATG1_YEASTATG1genetic
27708008
YPT32_YEASTYPT32genetic
27708008
MTC3_YEASTMTC3genetic
27708008
TAL2_YEASTNQM1genetic
27708008
ENV11_YEASTENV11genetic
27708008
DBF2_YEASTDBF2genetic
27708008
SDO1L_YEASTRTC3genetic
27708008
URM1_YEASTURM1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
PER33_YEASTPER33genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
HRB1_YEASTHRB1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
IDH1_YEASTIDH1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
TOM70_YEASTTOM70genetic
27708008
EAF7_YEASTEAF7genetic
27708008
ATP23_YEASTATP23genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
TLG2_YEASTTLG2genetic
27708008
YO024_YEASTYOL024Wgenetic
27708008
EXO1_YEASTEXO1genetic
27708008
PET20_YEASTPET20genetic
27708008
MDL2_YEASTMDL2genetic
27708008
SPEE_YEASTSPE3genetic
27708008
MSS18_YEASTMSS18genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IRC8_YEAST

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Related Literatures of Post-Translational Modification

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