| UniProt ID | KGUA_YEAST | |
|---|---|---|
| UniProt AC | P15454 | |
| Protein Name | Guanylate kinase | |
| Gene Name | GUK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 187 | |
| Subcellular Localization | ||
| Protein Description | Essential for recycling GMP and indirectly, cGMP.. | |
| Protein Sequence | MSRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELKDFIFAEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSRPIVISG ------CCCCEEEEC | 46.92 | 1314905 | |
| 2 | Phosphorylation | ------MSRPIVISG ------CCCCEEEEC | 46.92 | 27717283 | |
| 8 | Phosphorylation | MSRPIVISGPSGTGK CCCCEEEECCCCCCH | 33.48 | 27717283 | |
| 11 | Phosphorylation | PIVISGPSGTGKSTL CEEEECCCCCCHHHH | 53.14 | 27717283 | |
| 13 | Phosphorylation | VISGPSGTGKSTLLK EEECCCCCCHHHHHH | 45.86 | 27717283 | |
| 15 | Acetylation | SGPSGTGKSTLLKKL ECCCCCCHHHHHHHH | 39.85 | 24489116 | |
| 21 | Ubiquitination | GKSTLLKKLFAEYPD CHHHHHHHHHHHCCC | 49.13 | 23749301 | |
| 29 | Phosphorylation | LFAEYPDSFGFSVSS HHHHCCCCCCEECCC | 23.82 | 22369663 | |
| 33 | Phosphorylation | YPDSFGFSVSSTTRT CCCCCCEECCCCCCC | 22.82 | 22369663 | |
| 35 | Phosphorylation | DSFGFSVSSTTRTPR CCCCEECCCCCCCCC | 22.29 | 22369663 | |
| 36 | Phosphorylation | SFGFSVSSTTRTPRA CCCEECCCCCCCCCC | 31.48 | 22369663 | |
| 37 | Phosphorylation | FGFSVSSTTRTPRAG CCEECCCCCCCCCCE | 16.88 | 22369663 | |
| 38 | Phosphorylation | GFSVSSTTRTPRAGE CEECCCCCCCCCCEE | 34.20 | 22369663 | |
| 40 | Phosphorylation | SVSSTTRTPRAGEVN ECCCCCCCCCCEEEC | 18.29 | 22369663 | |
| 49 | Succinylation | RAGEVNGKDYNFVSV CCEEECCCCCCEEEH | 52.41 | 23954790 | |
| 49 | Acetylation | RAGEVNGKDYNFVSV CCEEECCCCCCEEEH | 52.41 | 24489116 | |
| 60 | Acetylation | FVSVDEFKSMIKNNE EEEHHHHHHHHHCCC | 36.75 | 24489116 | |
| 92 | Phosphorylation | SVKQVSKSGKTCILD EEEEECCCCCEEEEE | 37.71 | 19823750 | |
| 95 | Phosphorylation | QVSKSGKTCILDIDM EECCCCCEEEEEEEC | 14.33 | 19823750 | |
| 106 | Ubiquitination | DIDMQGVKSVKAIPE EEECCCCCEEEECHH | 57.25 | 22817900 | |
| 107 | Phosphorylation | IDMQGVKSVKAIPEL EECCCCCEEEECHHH | 26.83 | 19823750 | |
| 109 | Ubiquitination | MQGVKSVKAIPELNA CCCCCEEEECHHHCE | 47.92 | 22817900 | |
| 125 | Phosphorylation | FLFIAPPSVEDLKKR EEEECCCCHHHHHHH | 36.76 | 22369663 | |
| 130 | Succinylation | PPSVEDLKKRLEGRG CCCHHHHHHHHCCCC | 48.44 | 23954790 | |
| 130 | Acetylation | PPSVEDLKKRLEGRG CCCHHHHHHHHCCCC | 48.44 | 24489116 | |
| 146 | Ubiquitination | ETEESINKRLSAAQA CCHHHHHHHHHHHHH | 53.71 | 23749301 | |
| 146 | Acetylation | ETEESINKRLSAAQA CCHHHHHHHHHHHHH | 53.71 | 22865919 | |
| 149 | Phosphorylation | ESINKRLSAAQAELA HHHHHHHHHHHHHHH | 26.12 | 22369663 | |
| 157 | Phosphorylation | AAQAELAYAETGAHD HHHHHHHHHHHCCCC | 20.00 | 22890988 | |
| 160 | Phosphorylation | AELAYAETGAHDKVI HHHHHHHHCCCCEEE | 31.34 | 22890988 | |
| 165 | Acetylation | AETGAHDKVIVNDDL HHHCCCCEEEECCCH | 24.80 | 24489116 | |
| 174 | 2-Hydroxyisobutyrylation | IVNDDLDKAYKELKD EECCCHHHHHHHHHH | 62.00 | - | |
| 174 | Acetylation | IVNDDLDKAYKELKD EECCCHHHHHHHHHH | 62.00 | 24489116 | |
| 174 | Succinylation | IVNDDLDKAYKELKD EECCCHHHHHHHHHH | 62.00 | 23954790 | |
| 176 | Phosphorylation | NDDLDKAYKELKDFI CCCHHHHHHHHHHHH | 15.67 | 25005228 | |
| 177 | Acetylation | DDLDKAYKELKDFIF CCHHHHHHHHHHHHH | 62.52 | 24489116 | |
| 180 | Acetylation | DKAYKELKDFIFAEK HHHHHHHHHHHHCCC | 52.24 | 24489116 | |
| 180 | Succinylation | DKAYKELKDFIFAEK HHHHHHHHHHHHCCC | 52.24 | 23954790 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KGUA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KGUA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KGUA_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Refined structure of the complex between guanylate kinase and itssubstrate GMP at 2.0-A resolution."; Stehle T., Schulz G.E.; J. Mol. Biol. 224:1127-1141(1992). Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). | |
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY. | |
