| UniProt ID | KSP1_YEAST | |
|---|---|---|
| UniProt AC | P38691 | |
| Protein Name | Serine/threonine-protein kinase KSP1 | |
| Gene Name | KSP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1029 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | May act on PRP20.. | |
| Protein Sequence | MTLDYEIYKEGGILNNRYQKIEDISEGSYGYVSLAKDVREKRLVAVKYIFKLEDDGQYDGPQDDENDCDSSDCDDDEDTKVDTDRHENENGNASSNNGSSREKKHNLYKHKKSLISSKVKSRLSNNICLEAMYEVDIQTKIGRHQNIAALLDFFDSYIIMEYCSGGDLYEAIKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIKPENILISGIDWTIKLTDWGLATTDKTSMDRNVGSERYMSPELFDSNLDIKERKEPYDCAKVDLWAMGIVFLNIVFHKNPFSIANQSDKSFCYFAANREALFDVFSTMAYDFFQVLRYSLTIDPANRDLKMMRTELQNLSEYTLDDEYYNNLDEGYEETMIDGLPPQPVPPSSAPVSLPTPISSSNKQHMPEFKKDFNFNNVNERKRSDVSQNQNVASGFFKKPSTQQQKFFNQGYNTTLSTHERAKSAPKFKFKKRNKYGRTDNQFSKPVNIEDRKKSKILKKSRKPLGIPTPNTHMNNFFHDYKARDEFNTRDFFTPPSVQHRYMEGFSNNNNKQYRQNRNYNNNNNNSNNNHGSNYNNFNNGNSYIKGWNKNFNKYRRPSSSSYTGKSPLSRYNMSYNHNNNSSINGYARRGSTTTVQHSPGAYIPPNARNHHVSPTNQFLRVPQSTAPDISTVLGGKPSYQEHYTQDSMDSEGDHDSDDVLFTLEEGDHDFVNGMDNLSINDHLPHTTVGSHNEVFVHASTNHNNNGNNNHIDTNSTTNQYHRQYIPPPLTTSLHINNNNNESNELPDLLKSPASSEAHLNLSSGPIDPILTGNIGNRYSHSSDSKELEQERRLSMEQKFKNGVYVPPHHRKSFNLGTQVPPMNMKTSNEATLSVSHNSVNFGGSYNSRRSSANESNPLHMNKALEKLSSSPGAKSSFVGFPKPLLPRNHSSTTIALQNEDVFADSNNDAIIFEDEEYEGESDKMAHGKMEGGDNESSSTSPDERQIFGPYEIYAQTFAGSTHDKKLGAGRKTSIQDEMVGSLEQYKNNWLILQQQD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 70 | Phosphorylation | DDENDCDSSDCDDDE CCCCCCCCCCCCCCC | 34.11 | 28889911 | |
| 71 | Phosphorylation | DENDCDSSDCDDDED CCCCCCCCCCCCCCC | 29.07 | 28889911 | |
| 99 | Phosphorylation | NASSNNGSSREKKHN CCCCCCCCCHHHHHH | 28.48 | 28889911 | |
| 113 | Phosphorylation | NLYKHKKSLISSKVK HHHHHHHHHHHHHHH | 35.42 | 21440633 | |
| 116 | Phosphorylation | KHKKSLISSKVKSRL HHHHHHHHHHHHHHH | 29.42 | 28889911 | |
| 117 | Phosphorylation | HKKSLISSKVKSRLS HHHHHHHHHHHHHHC | 34.18 | 19684113 | |
| 121 | Phosphorylation | LISSKVKSRLSNNIC HHHHHHHHHHCCCCH | 41.25 | 19684113 | |
| 416 | Phosphorylation | NVNERKRSDVSQNQN CCCHHHHHHCCCCCC | 45.45 | 17330950 | |
| 419 | Phosphorylation | ERKRSDVSQNQNVAS HHHHHHCCCCCCHHH | 28.53 | 17330950 | |
| 426 | Phosphorylation | SQNQNVASGFFKKPS CCCCCHHHCCCCCCC | 31.67 | 21440633 | |
| 438 | Acetylation | KPSTQQQKFFNQGYN CCCHHHHHHHHCCCC | 47.81 | 22865919 | |
| 449 | Phosphorylation | QGYNTTLSTHERAKS CCCCCCCCHHHHHHC | 26.14 | 21440633 | |
| 450 | Phosphorylation | GYNTTLSTHERAKSA CCCCCCCHHHHHHCC | 30.76 | 19779198 | |
| 456 | Phosphorylation | STHERAKSAPKFKFK CHHHHHHCCCCCCCC | 49.14 | 21440633 | |
| 476 | Phosphorylation | GRTDNQFSKPVNIED CCCCCCCCCCCCHHH | 26.70 | 23749301 | |
| 493 | Phosphorylation | KSKILKKSRKPLGIP HHHHHHHCCCCCCCC | 43.90 | 24961812 | |
| 501 | Phosphorylation | RKPLGIPTPNTHMNN CCCCCCCCCCCCCCC | 27.53 | 19684113 | |
| 504 | Phosphorylation | LGIPTPNTHMNNFFH CCCCCCCCCCCCCCC | 24.57 | 20377248 | |
| 513 | Phosphorylation | MNNFFHDYKARDEFN CCCCCCCCCCCCCCC | 9.66 | 19823750 | |
| 521 | Phosphorylation | KARDEFNTRDFFTPP CCCCCCCCCCCCCCH | 36.62 | 24961812 | |
| 526 | Phosphorylation | FNTRDFFTPPSVQHR CCCCCCCCCHHHHHH | 33.99 | 22369663 | |
| 529 | Phosphorylation | RDFFTPPSVQHRYME CCCCCCHHHHHHHHC | 35.30 | 22369663 | |
| 534 | Phosphorylation | PPSVQHRYMEGFSNN CHHHHHHHHCCCCCC | 9.44 | 21440633 | |
| 539 | Phosphorylation | HRYMEGFSNNNNKQY HHHHCCCCCCCCHHH | 49.89 | 28889911 | |
| 552 | Phosphorylation | QYRQNRNYNNNNNNS HHHHHCCCCCCCCCC | 18.94 | 23749301 | |
| 559 | Phosphorylation | YNNNNNNSNNNHGSN CCCCCCCCCCCCCCC | 42.95 | 23749301 | |
| 565 | Phosphorylation | NSNNNHGSNYNNFNN CCCCCCCCCCCCCCC | 28.70 | 23749301 | |
| 575 | Phosphorylation | NNFNNGNSYIKGWNK CCCCCCCCCCCCCCC | 29.63 | 23749301 | |
| 576 | Phosphorylation | NFNNGNSYIKGWNKN CCCCCCCCCCCCCCC | 15.62 | 23749301 | |
| 591 | Phosphorylation | FNKYRRPSSSSYTGK CCCCCCCCCCCCCCC | 40.83 | 21082442 | |
| 592 | Phosphorylation | NKYRRPSSSSYTGKS CCCCCCCCCCCCCCC | 26.45 | 21440633 | |
| 593 | Phosphorylation | KYRRPSSSSYTGKSP CCCCCCCCCCCCCCC | 31.53 | 19684113 | |
| 594 | Phosphorylation | YRRPSSSSYTGKSPL CCCCCCCCCCCCCCH | 28.76 | 19684113 | |
| 595 | Phosphorylation | RRPSSSSYTGKSPLS CCCCCCCCCCCCCHH | 22.81 | 19684113 | |
| 596 | Phosphorylation | RPSSSSYTGKSPLSR CCCCCCCCCCCCHHH | 39.83 | 19684113 | |
| 599 | Phosphorylation | SSSYTGKSPLSRYNM CCCCCCCCCHHHCCC | 32.20 | 19684113 | |
| 602 | Phosphorylation | YTGKSPLSRYNMSYN CCCCCCHHHCCCCCC | 35.78 | 19684113 | |
| 607 | Phosphorylation | PLSRYNMSYNHNNNS CHHHCCCCCCCCCCC | 21.10 | 28889911 | |
| 608 | Phosphorylation | LSRYNMSYNHNNNSS HHHCCCCCCCCCCCC | 15.07 | 19779198 | |
| 614 | Phosphorylation | SYNHNNNSSINGYAR CCCCCCCCCCCCEEE | 34.42 | 28889911 | |
| 615 | Phosphorylation | YNHNNNSSINGYARR CCCCCCCCCCCEEEC | 23.38 | 23749301 | |
| 624 | Phosphorylation | NGYARRGSTTTVQHS CCEEECCCCCEEECC | 22.29 | 17330950 | |
| 625 | Phosphorylation | GYARRGSTTTVQHSP CEEECCCCCEEECCC | 29.34 | 28889911 | |
| 626 | Phosphorylation | YARRGSTTTVQHSPG EEECCCCCEEECCCC | 27.02 | 23749301 | |
| 627 | Phosphorylation | ARRGSTTTVQHSPGA EECCCCCEEECCCCC | 20.46 | 25752575 | |
| 631 | Phosphorylation | STTTVQHSPGAYIPP CCCEEECCCCCCCCC | 14.13 | 21082442 | |
| 635 | Phosphorylation | VQHSPGAYIPPNARN EECCCCCCCCCCCCC | 21.63 | 23749301 | |
| 646 | Phosphorylation | NARNHHVSPTNQFLR CCCCCCCCCCCCCCC | 22.96 | 17330950 | |
| 648 | Phosphorylation | RNHHVSPTNQFLRVP CCCCCCCCCCCCCCC | 33.86 | 28132839 | |
| 784 | Phosphorylation | ELPDLLKSPASSEAH CCCHHHHCCCCCCCH | 26.18 | 22369663 | |
| 787 | Phosphorylation | DLLKSPASSEAHLNL HHHHCCCCCCCHHCC | 31.90 | 22369663 | |
| 788 | Phosphorylation | LLKSPASSEAHLNLS HHHCCCCCCCHHCCC | 40.69 | 22369663 | |
| 795 | Phosphorylation | SEAHLNLSSGPIDPI CCCHHCCCCCCCCCC | 31.98 | 22369663 | |
| 796 | Phosphorylation | EAHLNLSSGPIDPIL CCHHCCCCCCCCCCE | 52.32 | 22369663 | |
| 804 | Phosphorylation | GPIDPILTGNIGNRY CCCCCCEECCCCCCC | 28.97 | 21440633 | |
| 811 | Phosphorylation | TGNIGNRYSHSSDSK ECCCCCCCCCCCCCH | 18.09 | 20377248 | |
| 812 | Phosphorylation | GNIGNRYSHSSDSKE CCCCCCCCCCCCCHH | 17.41 | 21440633 | |
| 814 | Phosphorylation | IGNRYSHSSDSKELE CCCCCCCCCCCHHHH | 29.87 | 25005228 | |
| 815 | Phosphorylation | GNRYSHSSDSKELEQ CCCCCCCCCCHHHHH | 40.24 | 20377248 | |
| 817 | Phosphorylation | RYSHSSDSKELEQER CCCCCCCCHHHHHHH | 29.94 | 19684113 | |
| 827 | Phosphorylation | LEQERRLSMEQKFKN HHHHHHHCHHHHHHC | 20.61 | 21551504 | |
| 845 | Phosphorylation | VPPHHRKSFNLGTQV CCCCCCCCCCCCCCC | 21.23 | 17330950 | |
| 850 | Phosphorylation | RKSFNLGTQVPPMNM CCCCCCCCCCCCCCC | 29.56 | 19779198 | |
| 866 | Phosphorylation | TSNEATLSVSHNSVN CCCCEEEEECCCCEE | 19.74 | 19779198 | |
| 868 | Phosphorylation | NEATLSVSHNSVNFG CCEEEEECCCCEECC | 17.36 | 23749301 | |
| 871 | Phosphorylation | TLSVSHNSVNFGGSY EEEECCCCEECCCCC | 17.02 | 23749301 | |
| 877 | Phosphorylation | NSVNFGGSYNSRRSS CCEECCCCCCCCCCC | 22.86 | 21440633 | |
| 878 | Phosphorylation | SVNFGGSYNSRRSSA CEECCCCCCCCCCCC | 22.04 | 19779198 | |
| 880 | Phosphorylation | NFGGSYNSRRSSANE ECCCCCCCCCCCCCC | 22.34 | 21551504 | |
| 883 | Phosphorylation | GSYNSRRSSANESNP CCCCCCCCCCCCCCC | 32.46 | 22369663 | |
| 884 | Phosphorylation | SYNSRRSSANESNPL CCCCCCCCCCCCCCH | 33.05 | 22369663 | |
| 888 | Phosphorylation | RRSSANESNPLHMNK CCCCCCCCCCHHHHH | 43.48 | 29136822 | |
| 901 | Phosphorylation | NKALEKLSSSPGAKS HHHHHHHHCCCCCCH | 39.58 | 19684113 | |
| 902 | Phosphorylation | KALEKLSSSPGAKSS HHHHHHHCCCCCCHH | 51.49 | 21440633 | |
| 903 | Phosphorylation | ALEKLSSSPGAKSSF HHHHHHCCCCCCHHC | 24.79 | 25521595 | |
| 908 | Phosphorylation | SSSPGAKSSFVGFPK HCCCCCCHHCCCCCC | 28.60 | 19684113 | |
| 909 | Phosphorylation | SSPGAKSSFVGFPKP CCCCCCHHCCCCCCC | 24.20 | 21440633 | |
| 915 | Acetylation | SSFVGFPKPLLPRNH HHCCCCCCCCCCCCC | 46.14 | 24489116 | |
| 954 | Phosphorylation | DEEYEGESDKMAHGK CCCCCCCCCCCCCCC | 54.08 | 28889911 | |
| 969 | Phosphorylation | MEGGDNESSSTSPDE CCCCCCCCCCCCCCH | 35.52 | 22890988 | |
| 970 | Phosphorylation | EGGDNESSSTSPDER CCCCCCCCCCCCCHH | 31.30 | 22890988 | |
| 971 | Phosphorylation | GGDNESSSTSPDERQ CCCCCCCCCCCCHHH | 42.03 | 22890988 | |
| 972 | Phosphorylation | GDNESSSTSPDERQI CCCCCCCCCCCHHHC | 46.34 | 22890988 | |
| 973 | Phosphorylation | DNESSSTSPDERQIF CCCCCCCCCCHHHCC | 32.09 | 11875433 | |
| 983 | Phosphorylation | ERQIFGPYEIYAQTF HHHCCCCHHHEEEEC | 18.48 | 24930733 | |
| 993 | Phosphorylation | YAQTFAGSTHDKKLG EEEECCCCCCCCCCC | 21.09 | 24930733 | |
| 994 | Phosphorylation | AQTFAGSTHDKKLGA EEECCCCCCCCCCCC | 32.93 | 24930733 | |
| 1005 | Phosphorylation | KLGAGRKTSIQDEMV CCCCCCCCCHHHHHC | 29.69 | 22369663 | |
| 1006 | Phosphorylation | LGAGRKTSIQDEMVG CCCCCCCCHHHHHCC | 22.68 | 25752575 | |
| 1014 | Phosphorylation | IQDEMVGSLEQYKNN HHHHHCCCHHHHHCC | 19.81 | 22369663 | |
| 1018 | Phosphorylation | MVGSLEQYKNNWLIL HCCCHHHHHCCEEEE | 13.30 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KSP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KSP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KSP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-526; SER-529; THR-627;SER-845 AND SER-1014, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-591 AND SER-827, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416; THR-526; SER-529;SER-646 AND SER-845, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-526 AND SER-529, ANDMASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-970 AND SER-973, ANDMASS SPECTROMETRY. | |
