TDA1_YEAST - dbPTM
TDA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TDA1_YEAST
UniProt AC Q03533
Protein Name Serine/threonine-protein kinase TDA1
Gene Name TDA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 586
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Serine/threonine protein kinase shown to have protein phosphorylation activity in vitro..
Protein Sequence MTTASSSASQLQQRLPEEKPWPQLSGSNADAQTFKCKYVTNHNSLGDGNFSVVKECMNIHTKDLYAMKLIKKQTVKNKIQLIQREFDLLRSISEKIRDMEKKNEHSLDIFEGHHHILQLFDYFETADNIVLITQLCQKGDLYEKIVENQCLDLETQVTSYCACLVSVLEFLHSQGIVHRDLKAENVLFRLRVNENEKNLQGEHHGDFKYDLLAHDLVLADFGLAAEYNTSKVNSLKEFVGTISYIAPEIVKCKGVGEMTPDQVGKLDKYGCPVDIWALGVLTYFMAFGYTPFDCTTDDETLECISKCDYYVDEQMMHDPKYEQFWNFVQCCFTIDPAVRRSAKNLKQHPFIKDYFATSNSLNTKDTPNFSFHPTIRRVSSTASMHTLRSPSKSRKTTTLAYLNMDGGSSETSTAFSSKMDLPDLYVDRTINSRERSLNRIRDTLKKTLSMTSLKPAGTFDYLHANKNGTSLSSSKSGLVKKNSTFVLDPKPPKNSLMNGCFSTTPESRSNFNTPKTLSRQGSSTSVKKYVNEVDLLLTPRTASMSSNDTTAINDYDTTNDKNPARKHAASFQVNVDDSDGDETMQI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTTASSSAS
------CCCCCCHHH		30.9422369663
3Phosphorylation-----MTTASSSASQ
-----CCCCCCHHHH		24.2022369663
5Phosphorylation---MTTASSSASQLQ
---CCCCCCHHHHHH		23.8024909858
6Phosphorylation--MTTASSSASQLQQ
--CCCCCCHHHHHHH		27.7122369663
7Phosphorylation-MTTASSSASQLQQR
-CCCCCCHHHHHHHH		29.4622369663
9PhosphorylationTTASSSASQLQQRLP
CCCCCHHHHHHHHCC		33.1122369663
25PhosphorylationEKPWPQLSGSNADAQ
CCCCCCCCCCCCCCC		34.6222369663
27PhosphorylationPWPQLSGSNADAQTF
CCCCCCCCCCCCCEE		26.0122369663
33PhosphorylationGSNADAQTFKCKYVT
CCCCCCCEEECEEEC		27.1222369663
37UbiquitinationDAQTFKCKYVTNHNS
CCCEEECEEECCCCC		43.2617644757
54UbiquitinationDGNFSVVKECMNIHT
CCCCHHHHHHHHCCC		42.9417644757
243PhosphorylationKEFVGTISYIAPEIV
HHHHHHHHHHCHHHH		15.4321440633
259PhosphorylationCKGVGEMTPDQVGKL
CCCCCCCCHHHCCCC		21.2922369663
354PhosphorylationQHPFIKDYFATSNSL
CCCCHHHHHCCCCCC		7.0722369663
357PhosphorylationFIKDYFATSNSLNTK
CHHHHHCCCCCCCCC		20.6722369663
358PhosphorylationIKDYFATSNSLNTKD
HHHHHCCCCCCCCCC		22.4622369663
360PhosphorylationDYFATSNSLNTKDTP
HHHCCCCCCCCCCCC		23.8222369663
363PhosphorylationATSNSLNTKDTPNFS
CCCCCCCCCCCCCCC		35.2722369663
364UbiquitinationTSNSLNTKDTPNFSF
CCCCCCCCCCCCCCC		59.5417644757
366PhosphorylationNSLNTKDTPNFSFHP
CCCCCCCCCCCCCCC		22.9922369663
370PhosphorylationTKDTPNFSFHPTIRR
CCCCCCCCCCCCCEE		29.3221551504
374PhosphorylationPNFSFHPTIRRVSST
CCCCCCCCCEECCCC		20.6722369663
379PhosphorylationHPTIRRVSSTASMHT
CCCCEECCCCCCHHC		21.8422369663
380PhosphorylationPTIRRVSSTASMHTL
CCCEECCCCCCHHCC		25.7422369663
381PhosphorylationTIRRVSSTASMHTLR
CCEECCCCCCHHCCC		18.4222890988
383PhosphorylationRRVSSTASMHTLRSP
EECCCCCCHHCCCCC		15.9322369663
386PhosphorylationSSTASMHTLRSPSKS
CCCCCHHCCCCCCCC		18.4122890988
389PhosphorylationASMHTLRSPSKSRKT
CCHHCCCCCCCCCCC		36.3222369663
391PhosphorylationMHTLRSPSKSRKTTT
HHCCCCCCCCCCCEE		44.5022369663
393PhosphorylationTLRSPSKSRKTTTLA
CCCCCCCCCCCEEEE		43.2620377248
396PhosphorylationSPSKSRKTTTLAYLN
CCCCCCCCEEEEEEE		24.7324961812
397PhosphorylationPSKSRKTTTLAYLNM
CCCCCCCEEEEEEEC		23.8924961812
398PhosphorylationSKSRKTTTLAYLNMD
CCCCCCEEEEEEECC		18.0220377248
401PhosphorylationRKTTTLAYLNMDGGS
CCCEEEEEEECCCCC		11.1719823750
408PhosphorylationYLNMDGGSSETSTAF
EEECCCCCCCCHHHC		30.4522369663
409PhosphorylationLNMDGGSSETSTAFS
EECCCCCCCCHHHCC		48.4422369663
411PhosphorylationMDGGSSETSTAFSSK
CCCCCCCCHHHCCCC		33.0722369663
412PhosphorylationDGGSSETSTAFSSKM
CCCCCCCHHHCCCCC		17.4322369663
413PhosphorylationGGSSETSTAFSSKMD
CCCCCCHHHCCCCCC		38.8622369663
416PhosphorylationSETSTAFSSKMDLPD
CCCHHHCCCCCCCCH		26.9522369663
417PhosphorylationETSTAFSSKMDLPDL
CCHHHCCCCCCCCHH		26.0822369663
425PhosphorylationKMDLPDLYVDRTINS
CCCCCHHHHCCCCHH		14.0022369663
429PhosphorylationPDLYVDRTINSRERS
CHHHHCCCCHHHHHH		21.7522369663
432PhosphorylationYVDRTINSRERSLNR
HHCCCCHHHHHHHHH		31.5022369663
436PhosphorylationTINSRERSLNRIRDT
CCHHHHHHHHHHHHH		25.8320377248
443PhosphorylationSLNRIRDTLKKTLSM
HHHHHHHHHHHHHCC		30.5424961812
447PhosphorylationIRDTLKKTLSMTSLK
HHHHHHHHHCCCCCC		23.6020377248
449PhosphorylationDTLKKTLSMTSLKPA
HHHHHHHCCCCCCCC		25.8322369663
451PhosphorylationLKKTLSMTSLKPAGT
HHHHHCCCCCCCCCE		27.7722369663
452PhosphorylationKKTLSMTSLKPAGTF
HHHHCCCCCCCCCEE		26.2525521595
458PhosphorylationTSLKPAGTFDYLHAN
CCCCCCCEECEEEEC		18.5520377248
461PhosphorylationKPAGTFDYLHANKNG
CCCCEECEEEECCCC		9.0122369663
470PhosphorylationHANKNGTSLSSSKSG
EECCCCCCCCCCCCC		27.8728889911
474PhosphorylationNGTSLSSSKSGLVKK
CCCCCCCCCCCCCCC		27.7128889911
476PhosphorylationTSLSSSKSGLVKKNS
CCCCCCCCCCCCCCC		39.0321440633
483PhosphorylationSGLVKKNSTFVLDPK
CCCCCCCCEEECCCC		31.9122369663
484PhosphorylationGLVKKNSTFVLDPKP
CCCCCCCEEECCCCC		27.4422369663
495PhosphorylationDPKPPKNSLMNGCFS
CCCCCCCCCCCCCCC		34.8121440633
502PhosphorylationSLMNGCFSTTPESRS
CCCCCCCCCCCCHHC		35.1322369663
503PhosphorylationLMNGCFSTTPESRSN
CCCCCCCCCCCHHCC		26.5620377248
504PhosphorylationMNGCFSTTPESRSNF
CCCCCCCCCCHHCCC		24.7022369663
507PhosphorylationCFSTTPESRSNFNTP
CCCCCCCHHCCCCCC		42.0622369663
509PhosphorylationSTTPESRSNFNTPKT
CCCCCHHCCCCCCCC		55.8622369663
513PhosphorylationESRSNFNTPKTLSRQ
CHHCCCCCCCCHHCC		23.2522369663
516PhosphorylationSNFNTPKTLSRQGSS
CCCCCCCCHHCCCCC		31.0422369663
518PhosphorylationFNTPKTLSRQGSSTS
CCCCCCHHCCCCCHH		27.9922369663
522PhosphorylationKTLSRQGSSTSVKKY
CCHHCCCCCHHHHHH		23.3122369663
523PhosphorylationTLSRQGSSTSVKKYV
CHHCCCCCHHHHHHH		31.3720377248
524PhosphorylationLSRQGSSTSVKKYVN
HHCCCCCHHHHHHHC		38.9622369663
525PhosphorylationSRQGSSTSVKKYVNE
HCCCCCHHHHHHHCE		33.6122369663
538PhosphorylationNEVDLLLTPRTASMS
CEECEEECCCCCCCC		15.6422369663
541PhosphorylationDLLLTPRTASMSSND
CEEECCCCCCCCCCC		25.0422369663
543PhosphorylationLLTPRTASMSSNDTT
EECCCCCCCCCCCCC		20.7022369663
545PhosphorylationTPRTASMSSNDTTAI
CCCCCCCCCCCCCCC		24.4022369663
546PhosphorylationPRTASMSSNDTTAIN
CCCCCCCCCCCCCCC		30.0422369663
549PhosphorylationASMSSNDTTAINDYD
CCCCCCCCCCCCCCC		23.5222369663
550PhosphorylationSMSSNDTTAINDYDT
CCCCCCCCCCCCCCC		28.5321440633
555PhosphorylationDTTAINDYDTTNDKN
CCCCCCCCCCCCCCC		15.6522369663
557PhosphorylationTAINDYDTTNDKNPA
CCCCCCCCCCCCCHH		22.6722369663
558PhosphorylationAINDYDTTNDKNPAR
CCCCCCCCCCCCHHH		38.2222369663
561UbiquitinationDYDTTNDKNPARKHA
CCCCCCCCCHHHHCE		67.8923749301
570PhosphorylationPARKHAASFQVNVDD
HHHHCEEEEEEECCC		19.5922369663
578PhosphorylationFQVNVDDSDGDETMQ
EEEECCCCCCCCCCC		38.7420377248
583PhosphorylationDDSDGDETMQI----
CCCCCCCCCCC----		21.0822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TDA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TDA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TDA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS33_YEASTVPS33physical
11805837
FUMH_YEASTFUM1physical
11805837
DIN7_YEASTDIN7physical
16554755
PTK2_YEASTPTK2physical
16319894
LEUC_YEASTLEU1physical
20489023
PDI_YEASTPDI1physical
20489023
SKP1_YEASTSKP1physical
20489023
ARP8_YEASTARP8physical
21460040
IWR1_YEASTIWR1physical
21460040
PSA3_YEASTPRE9physical
21460040
KPR1_YEASTPRS1physical
21460040
RIM11_YEASTRIM11physical
21460040
RTR1_YEASTRTR1physical
21460040
COPB2_YEASTSEC27physical
21460040
UBC8_YEASTUBC8physical
21460040
VPS21_YEASTVPS21physical
21460040
YPT32_YEASTYPT32physical
21460040
SRS2_YEASTSRS2genetic
21459050
CG11_YEASTCLN1genetic
21127252
CHA4_YEASTCHA4genetic
21127252
HCM1_YEASTHCM1genetic
21127252
PLM2_YEASTPLM2genetic
21127252
YGN8_YEASTYGL138Cgenetic
22282571
VTC3_YEASTVTC3genetic
22282571
IMG2_YEASTIMG2genetic
22282571
ERG3_YEASTERG3genetic
22282571
ERG6_YEASTERG6genetic
22282571
MSB4_YEASTMSB4genetic
22282571
ATP23_YEASTATP23genetic
22282571
HXKB_YEASTHXK2physical
25593311
MRM2_YEASTMRM2genetic
27708008
ETR1_YEASTETR1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
NDH2_YEASTNDE2genetic
27708008
DCOR_YEASTSPE1genetic
27708008
ERG3_YEASTERG3genetic
27708008
FABD_YEASTMCT1genetic
27708008
PP2B1_YEASTCNA1physical
24930733
PP2B2_YEASTCMP2physical
24930733
OCA5_YEASTOCA5genetic
29674565
MDM10_YEASTMDM10genetic
29674565
TRS20_YEASTTRS20genetic
29674565
SNT1_YEASTSNT1genetic
29674565
TPS2_YEASTTPS2genetic
29674565
TFB1_YEASTTFB1genetic
29674565
VPS72_YEASTVPS72genetic
29674565
SCS2_YEASTSCS2genetic
29674565
PT122_YEASTPET122genetic
29674565
YPT1_YEASTYPT1genetic
29674565
ELP2_YEASTELP2genetic
29674565
PHB2_YEASTPHB2genetic
29674565
STS1_YEASTSTS1genetic
29674565
PRP21_YEASTPRP21genetic
29674565
CAPZA_YEASTCAP1genetic
29674565
RS30A_YEASTRPS30Agenetic
29674565
RS30B_YEASTRPS30Agenetic
29674565
F16P_YEASTFBP1genetic
29674565
PET8_YEASTPET8genetic
29674565
CAP_YEASTSRV2genetic
29674565
SIN3_YEASTSIN3genetic
29674565
DCAM_YEASTSPE2genetic
29674565
MET22_YEASTMET22genetic
29674565
MED7_YEASTMED7genetic
29674565
PT127_YEASTPET127genetic
29674565
APC5_YEASTAPC5genetic
29674565
HSP7F_YEASTSSE1genetic
29674565
BEM4_YEASTBEM4genetic
29674565
RTC6_YEASTRTC6genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TDA1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-380; SER-383;SER-408; SER-409; THR-411; SER-449; THR-503; THR-504; SER-507; THR-513AND THR-541, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-449; SER-452;THR-516; SER-523; SER-525 AND SER-543, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-483; THR-484;SER-518 AND SER-522, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380 AND THR-538, ANDMASS SPECTROMETRY.

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