| UniProt ID | IWR1_YEAST | |
|---|---|---|
| UniProt AC | Q07532 | |
| Protein Name | RNA polymerase II nuclear localization protein IWR1 | |
| Gene Name | IWR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 353 | |
| Subcellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. | |
| Protein Description | Directs RNA polymerase II nuclear import. Binds RNA polymerase II in the active center cleft between the two largest subunits in the cytoplasm. Then uses an N-terminal bipartite nuclear localization signal that may be recognized by karyopherin alpha to direct the polymerase II complex nuclear import. In the nucleus, is displaced from polymerase II complex by transcription initiation factors and nucleic acids, enabling its export and recycling.. | |
| Protein Sequence | MSTISTTTAPEFIRVKRRRDEDSVQALLIDEGKRVKKQKFIFKLSKTVSSESYQSEQESSTPLLKLAHEDHRHFVLEQRKKSRRDSDDEKSQQRLAAEGSTVDDDGLPPEINQMVNDYLKLNKGVEKTERKKPSRKYFTGDSAKIASLPSLDYVFDIYHLEKIHDDEVARYNNEKNIGFVKIIEHIDLALDEESDPNEARSDDEDSNDENYYQNDYPEDEDDDRSILFGSEGEDIAALGEEIVIGVNKSRFSSWNDDKIQGSNGYHDVEEEYGDLFNRLGGKSDVLKSINSSNFIDLDGQEGEIEISDNEDDSDEGDDIEYPRNEFFPTDVDDPLAHHRDRIFHQLQKKINRS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSTISTTTA ------CCCCCCCCC | 34.15 | 22814378 | |
| 2 | Phosphorylation | ------MSTISTTTA ------CCCCCCCCC | 34.15 | 30377154 | |
| 6 | Phosphorylation | --MSTISTTTAPEFI --CCCCCCCCCCHHH | 25.06 | 30377154 | |
| 7 | Phosphorylation | -MSTISTTTAPEFIR -CCCCCCCCCCHHHE | 17.73 | 30377154 | |
| 8 | Phosphorylation | MSTISTTTAPEFIRV CCCCCCCCCCHHHEE | 40.06 | 30377154 | |
| 47 | Phosphorylation | FIFKLSKTVSSESYQ EEEEEEECCCCHHHH | 23.42 | 22369663 | |
| 49 | Phosphorylation | FKLSKTVSSESYQSE EEEEECCCCHHHHCC | 33.35 | 22369663 | |
| 50 | Phosphorylation | KLSKTVSSESYQSEQ EEEECCCCHHHHCCC | 26.65 | 22369663 | |
| 52 | Phosphorylation | SKTVSSESYQSEQES EECCCCHHHHCCCCC | 30.35 | 22369663 | |
| 53 | Phosphorylation | KTVSSESYQSEQESS ECCCCHHHHCCCCCC | 16.41 | 22369663 | |
| 55 | Phosphorylation | VSSESYQSEQESSTP CCCHHHHCCCCCCCC | 32.77 | 22369663 | |
| 59 | Phosphorylation | SYQSEQESSTPLLKL HHHCCCCCCCCHHHH | 38.92 | 22369663 | |
| 82 | Phosphorylation | VLEQRKKSRRDSDDE HHHHHHHHCCCCCCH | 35.27 | 27717283 | |
| 86 | Phosphorylation | RKKSRRDSDDEKSQQ HHHHCCCCCCHHHHH | 45.19 | 19684113 | |
| 100 | Phosphorylation | QRLAAEGSTVDDDGL HHHHHCCCCCCCCCC | 19.43 | 30377154 | |
| 101 | Phosphorylation | RLAAEGSTVDDDGLP HHHHCCCCCCCCCCC | 38.52 | 27017623 | |
| 147 | Phosphorylation | GDSAKIASLPSLDYV CCHHHHHCCCCCCEE | 44.26 | 22369663 | |
| 150 | Phosphorylation | AKIASLPSLDYVFDI HHHHCCCCCCEEEEE | 38.88 | 22369663 | |
| 153 | Phosphorylation | ASLPSLDYVFDIYHL HCCCCCCEEEEEEEH | 14.33 | 22369663 | |
| 158 | Phosphorylation | LDYVFDIYHLEKIHD CCEEEEEEEHHHHCH | 11.38 | 22369663 | |
| 194 | Phosphorylation | DLALDEESDPNEARS HHHCCCCCCCCCCCC | 57.21 | 22369663 | |
| 225 | Phosphorylation | EDEDDDRSILFGSEG CCCCCCCCEECCCCC | 30.55 | 29650682 | |
| 230 | Phosphorylation | DRSILFGSEGEDIAA CCCEECCCCCCCHHH | 34.78 | 29650682 | |
| 252 | Phosphorylation | GVNKSRFSSWNDDKI EEEHHHCCCCCCCCC | 33.08 | 19779198 | |
| 262 | Phosphorylation | NDDKIQGSNGYHDVE CCCCCCCCCCCCCHH | 15.65 | 22369663 | |
| 265 | Phosphorylation | KIQGSNGYHDVEEEY CCCCCCCCCCHHHHH | 10.09 | 22369663 | |
| 283 | Phosphorylation | FNRLGGKSDVLKSIN HHHHCCCHHHHHHHC | 35.90 | 23749301 | |
| 313 | Phosphorylation | ISDNEDDSDEGDDIE ECCCCCCCCCCCCCC | 50.30 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IWR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IWR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IWR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313, AND MASSSPECTROMETRY. | |
