| UniProt ID | COG4_YEAST | |
|---|---|---|
| UniProt AC | Q06096 | |
| Protein Name | Conserved oligomeric Golgi complex subunit 4 | |
| Gene Name | COG4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 861 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein . Golgi apparatus membrane Peripheral membrane protein . |
|
| Protein Description | Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG4 is required for normal endoplasmic reticulum function and is also involved in calcium regulation. Possesses ATPase activity.. | |
| Protein Sequence | MEGQKSNASWESSIIEGQLSKNLARYTLLLDKLSTLSQIDKLSEVIANDYAKQSKQLNAFVQQSQSSLNKESRKLELQRTNLTTTLTQFHETVATISSSNARAKAIHDDIETVDQERALVNKTLQFVKDVRTLKNNISLAHSALETKDYLVAATAINEIRSLPDKKLIVSEFAKKVVPSSEIPEEPAILIKNWCKELTSLFQEQFMEATRTQDIKELTLMFKMFPMIGQDVLGLDLYSKYVCDIIADESRKIMSNSMENSTKFQGFFSQVLLHLFKIVSTIINDHSKVIATCYGKKHMVHVMEKVEKEADLQASLILDIFMETRKIERTIHDINEWEHSQKNEDVNIDSNQSDIETDGETEKSSIISIHDLALLIMEFSQILQNWSMYSRFYSVKWNEFSDLHPHVLQPPPPIADGKFALKLKQDKVFDEFQVFVLNHLQRSFRNSISLEELPSLNDLITAVPLNDHDNISYPVTSVLDDLILLVRKNLISVVNTGQFKLLASFLNELVKFFQNRFLVKFMQNKFKLLQSKLASNVSLKRYIPKGEEQSATSRSVSPPANKFSPLSRFTFRGAAASALTNIQSNLQAVVAEDEDSILALHHYLIYLNTLYLSKVYVHRLLSIEILEDDSQRILRDNFPFDNDAAQLQNLIINSEKLVLEQTDKLSKWAVKYLFQNILQNRVRNLLGTVFVNSASSNSSTSNQKNVSRDYSAGSNQKNYITSIEDFEDLSQINSFNSKWNQLIIPYKNILHNEAYAELLSVIVDYIVTTLEQRIWTLEFNELGVTKLDRELSLFIGNMCGLNYNLREKFLKLTQIVLLLGLDDDNFDLTTGDIKDDFNGTFDWVINSQERIKARNMKIDRTQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Phosphorylation | SEVIANDYAKQSKQL HHHHHHHHHHHHHHH | 18.59 | 21126336 | |
| 80 | Phosphorylation | RKLELQRTNLTTTLT HHHHHHHHCCHHHHH | 22.94 | 27017623 | |
| 84 | Phosphorylation | LQRTNLTTTLTQFHE HHHHCCHHHHHHHHH | 23.99 | 27017623 | |
| 85 | Phosphorylation | QRTNLTTTLTQFHET HHHCCHHHHHHHHHH | 23.67 | 27017623 | |
| 87 | Phosphorylation | TNLTTTLTQFHETVA HCCHHHHHHHHHHHH | 27.39 | 19779198 | |
| 95 | Phosphorylation | QFHETVATISSSNAR HHHHHHHHHCCCCHH | 19.63 | 27017623 | |
| 97 | Phosphorylation | HETVATISSSNARAK HHHHHHHCCCCHHHH | 24.29 | 19779198 | |
| 99 | Phosphorylation | TVATISSSNARAKAI HHHHHCCCCHHHHHH | 27.93 | 27017623 | |
| 146 | Phosphorylation | LAHSALETKDYLVAA HHHHHHHCCHHHHHH | 30.02 | 29688323 | |
| 256 | Phosphorylation | SRKIMSNSMENSTKF HHHHHHCCCCCCHHH | 21.84 | 27017623 | |
| 260 | Phosphorylation | MSNSMENSTKFQGFF HHCCCCCCHHHHHHH | 21.48 | 27017623 | |
| 268 | Phosphorylation | TKFQGFFSQVLLHLF HHHHHHHHHHHHHHH | 19.67 | 27017623 | |
| 349 | Phosphorylation | NEDVNIDSNQSDIET CCCCCCCCCCCCCCC | 32.73 | 22369663 | |
| 352 | Phosphorylation | VNIDSNQSDIETDGE CCCCCCCCCCCCCCC | 44.82 | 22369663 | |
| 356 | Phosphorylation | SNQSDIETDGETEKS CCCCCCCCCCCCCCC | 50.03 | 22369663 | |
| 360 | Phosphorylation | DIETDGETEKSSIIS CCCCCCCCCCCCEEE | 55.00 | 19823750 | |
| 534 | Phosphorylation | LLQSKLASNVSLKRY HHHHHHHCCCCCEEC | 48.47 | 30377154 | |
| 554 | Phosphorylation | EQSATSRSVSPPANK CCCCCCCCCCCCCCC | 27.06 | 21551504 | |
| 556 | Phosphorylation | SATSRSVSPPANKFS CCCCCCCCCCCCCCC | 26.81 | 25521595 | |
| 563 | Phosphorylation | SPPANKFSPLSRFTF CCCCCCCCCCCHHCH | 26.92 | 23749301 | |
| 663 | Acetylation | LVLEQTDKLSKWAVK HHHHCHHHHHHHHHH | 59.03 | 24489116 | |
| 710 | Phosphorylation | KNVSRDYSAGSNQKN CCCCCCCCCCCCCCC | 30.37 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COG4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COG4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COG4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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