| UniProt ID | RPAB1_YEAST | |
|---|---|---|
| UniProt AC | P20434 | |
| Protein Name | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | |
| Gene Name | RPB5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 215 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerase complexes are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.. | |
| Protein Sequence | MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | QENERNISRLWRAFR HHHHHHHHHHHHHHH | 25.52 | 28889911 | |
| 158 | Phosphorylation | PKHIRLSSDEKRELL CCCCCCCHHHHHHHH | 55.15 | 27214570 | |
| 171 | Ubiquitination | LLKRYRLKESQLPRI HHHHHCCCHHCCCCH | 46.45 | 23749301 | |
| 191 | Ubiquitination | VALYLGLKRGEVVKI HHHHHCCCCCCEEEE | 57.46 | 23749301 | |
| 191 | Acetylation | VALYLGLKRGEVVKI HHHHHCCCCCCEEEE | 57.46 | 24489116 | |
| 197 | Ubiquitination | LKRGEVVKIIRKSET CCCCCEEEEEECCCC | 37.28 | 23749301 | |
| 201 | Ubiquitination | EVVKIIRKSETSGRY CEEEEEECCCCCCCC | 42.08 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPAB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPAB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPAB1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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