RPC4_YEAST - dbPTM
RPC4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPC4_YEAST
UniProt AC P25441
Protein Name DNA-directed RNA polymerase III subunit RPC4
Gene Name RPC53
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 422
Subcellular Localization Nucleus .
Protein Description DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation..
Protein Sequence MSSNKGNGRLPSLKDSSSNGGGSAKPSLKFKPKAVARKSKEEREAAASKVKLEEESKRGNDKKHFNNKNKRVTGAGGQQRRMAKYLNNTHVISSGPLAAGNFVSEKGDLRRGFIKSEGSGSSLVQKGLETIDNGAESSENEAEDDDNEGVASKSKKKFNMGKEFEARNLIEDEDDGESEKSSDVDMDDEEWRSKRIEQLFPVRPVRVRHEDVETVKREIQEALSEKPTREPTPSVKTEPVGTGLQSYLEERERQVNEKLADLGLEKEFQSVDGKEAAAELELLNADHQHILRKLKKMNNKPERFMVFQLPTRLPAFERPAVKEEKEDMETQASDPSKKKKNIKKKDTKDALSTRELAGKVGSIRVHKSGKLSVKIGNVVMDIGKGAETTFLQDVIALSIADDASSAELLGRVDGKIVVTPQI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationKGNGRLPSLKDSSSN
CCCCCCCCCCCCCCC		53.2823749301
27PhosphorylationGGGSAKPSLKFKPKA
CCCCCCCCCCCCHHH		43.4128889911
29AcetylationGSAKPSLKFKPKAVA
CCCCCCCCCCHHHHH		56.5325381059
49AcetylationEREAAASKVKLEEES
HHHHHHHHCHHHHHH		38.3725381059
84AcetylationGQQRRMAKYLNNTHV
HHHHHHHHHHCCCEE		40.7124489116
106AcetylationAGNFVSEKGDLRRGF
CCCCCCCCCCCCCCC		50.6624489116
115AcetylationDLRRGFIKSEGSGSS
CCCCCCCCCCCCCCH		39.9524489116
116PhosphorylationLRRGFIKSEGSGSSL
CCCCCCCCCCCCCHH		42.2328889911
119PhosphorylationGFIKSEGSGSSLVQK
CCCCCCCCCCHHHHH		31.3022369663
121PhosphorylationIKSEGSGSSLVQKGL
CCCCCCCCHHHHHHH		23.3821440633
122PhosphorylationKSEGSGSSLVQKGLE
CCCCCCCHHHHHHHH		35.7622369663
130PhosphorylationLVQKGLETIDNGAES
HHHHHHHHCCCCCCC		38.3822369663
137PhosphorylationTIDNGAESSENEAED
HCCCCCCCCCCCCCC		42.2822369663
138PhosphorylationIDNGAESSENEAEDD
CCCCCCCCCCCCCCC		35.6322369663
152PhosphorylationDDNEGVASKSKKKFN
CCCCCCCHHHHHCCC		34.7519795423
162AcetylationKKKFNMGKEFEARNL
HHCCCCCCHHHHHHC		48.7624489116
178PhosphorylationEDEDDGESEKSSDVD
CCCCCCCCCCCCCCC		56.7222369663
181PhosphorylationDDGESEKSSDVDMDD
CCCCCCCCCCCCCCH		27.9322369663
182PhosphorylationDGESEKSSDVDMDDE
CCCCCCCCCCCCCHH		53.3622369663
193PhosphorylationMDDEEWRSKRIEQLF
CCHHHHHHHHHHHHC		27.6221440633
224PhosphorylationREIQEALSEKPTREP
HHHHHHHHCCCCCCC		51.0922369663
226AcetylationIQEALSEKPTREPTP
HHHHHHCCCCCCCCC		48.6024489116
228PhosphorylationEALSEKPTREPTPSV
HHHHCCCCCCCCCCC		59.7525521595
232PhosphorylationEKPTREPTPSVKTEP
CCCCCCCCCCCCCCC		24.3622369663
234PhosphorylationPTREPTPSVKTEPVG
CCCCCCCCCCCCCCC		38.4322890988
258AcetylationRERQVNEKLADLGLE
HHHHHHHHHHHHCCH		43.7124489116
266AcetylationLADLGLEKEFQSVDG
HHHHCCHHHHCCCCH		69.7224489116
266UbiquitinationLADLGLEKEFQSVDG
HHHHCCHHHHCCCCH		69.7223749301
270PhosphorylationGLEKEFQSVDGKEAA
CCHHHHCCCCHHHHH		27.7430377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPC4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPC4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPC4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPC5_YEASTRPC37physical
10688190
TFC4_YEASTTFC4physical
10393904
RPC5_YEASTRPC37physical
10393904
SSD1_YEASTSSD1genetic
8510644
RPC10_YEASTRPC11physical
16554755
RPC9_YEASTRPC17physical
16554755
RPC8_YEASTRPC25physical
16554755
CASP_YEASTCOY1physical
16554755
RPC5_YEASTRPC37physical
16554755
RPAC2_YEASTRPC19physical
16554755
RPC7_YEASTRPC31physical
16554755
RPC6_YEASTRPC34physical
16554755
RPC1_YEASTRPO31physical
16554755
RPC2_YEASTRET1physical
16554755
RPAB5_YEASTRPB10physical
16554755
RPAB3_YEASTRPB8physical
16554755
RPAC1_YEASTRPC40physical
16554755
RPAB2_YEASTRPO26physical
16554755
RPC3_YEASTRPC82physical
16554755
END3_YEASTEND3physical
16429126
RPC2_YEASTRET1physical
16429126
RPC9_YEASTRPC17physical
16429126
RPAC2_YEASTRPC19physical
16429126
RPC8_YEASTRPC25physical
16429126
RPC6_YEASTRPC34physical
16429126
RPC5_YEASTRPC37physical
16429126
RPAB3_YEASTRPB8physical
16429126
RPC7_YEASTRPC31physical
16429126
RPAC1_YEASTRPC40physical
16429126
RPC3_YEASTRPC82physical
16429126
RPAB2_YEASTRPO26physical
16429126
ECM33_YEASTECM33genetic
20093466
BLM10_YEASTBLM10genetic
20093466
AP3B_YEASTAPL6genetic
20093466
ECM34_YEASTECM34genetic
20093466
MUP3_YEASTMUP3genetic
20093466
WSC4_YEASTWSC4genetic
20093466
UGPA2_YEASTYHL012Wgenetic
20093466
YHA8_YEASTYHL008Cgenetic
20093466
SLT2_YEASTSLT2genetic
20093466
PIH1_YEASTPIH1genetic
20093466
UBA4_YEASTUBA4genetic
20093466
LIN1_YEASTLIN1genetic
20093466
PTH_YEASTPTH1genetic
20093466
CRG1_YEASTCRG1genetic
20093466
COPE_YEASTSEC28genetic
20093466
SET2_YEASTSET2genetic
20093466
MTC1_YEASTMTC1genetic
20093466
SDHX_YEASTYJL045Wgenetic
20093466
GYP6_YEASTGYP6genetic
20093466
SPC1_YEASTSPC1genetic
20093466
RAD26_YEASTRAD26genetic
20093466
CYC1_YEASTCYC1genetic
20093466
AIM24_YEASTAIM24genetic
20093466
JSN1_YEASTJSN1genetic
20093466
MRT4_YEASTMRT4genetic
20093466
RL40A_YEASTRPL40Bgenetic
20093466
RL40B_YEASTRPL40Bgenetic
20093466
VPS13_YEASTVPS13genetic
20093466
MMM1_YEASTMMM1genetic
20093466
MTAP_YEASTMEU1genetic
20093466
SMF3_YEASTSMF3genetic
20093466
YPT6_YEASTYPT6genetic
20093466
ELP1_YEASTIKI3genetic
20093466
ATP10_YEASTATP10genetic
20093466
CAC2_YEASTCAC2genetic
20093466
RCF1_YEASTRCF1genetic
20093466
RIM11_YEASTRIM11genetic
20093466
YM39_YEASTYMR166Cgenetic
20093466
PFKA2_YEASTPFK2genetic
20093466
ADE_YEASTAAH1genetic
20093466
AF9_YEASTYAF9genetic
20093466
PET8_YEASTPET8genetic
20093466
BRE5_YEASTBRE5genetic
20093466
SKM1_YEASTSKM1genetic
20093466
IRA2_YEASTIRA2genetic
20093466
TSR3_YEASTTSR3genetic
20093466
VPS21_YEASTVPS21genetic
20093466
LDB19_YEASTLDB19genetic
20093466
SUR1_YEASTSUR1genetic
20093466
MTNA_YEASTMRI1genetic
20093466
RPC5_YEASTRPC37physical
21536656
RPC2_YEASTRET1physical
21536656
RPC3_YEASTRPC82physical
21536656
RPC8_YEASTRPC25physical
21536656
RPC6_YEASTRPC34physical
21536656
RPC1_YEASTRPO31physical
21536656
RPC9_YEASTRPC17physical
21536656
TFC4_YEASTTFC4physical
21536656
RIM11_YEASTRIM11genetic
22282571
SLT2_YEASTSLT2genetic
22282571
MOD5_YEASTMOD5physical
23898186
PMS1_YEASTPMS1genetic
27708008
SYIC_YEASTILS1genetic
27708008
ALG14_YEASTALG14genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
CDK1_YEASTCDC28genetic
27708008
SNU56_YEASTSNU56genetic
27708008
PRP28_YEASTPRP28genetic
27708008
TFC6_YEASTTFC6genetic
27708008
RNA15_YEASTRNA15genetic
27708008
PRP43_YEASTPRP43genetic
27708008
SMD1_YEASTSMD1genetic
27708008
RPC9_YEASTRPC17genetic
27708008
ARP3_YEASTARP3genetic
27708008
FIP1_YEASTFIP1genetic
27708008
SN114_YEASTSNU114genetic
27708008
PRP19_YEASTPRP19genetic
27708008
BBP_YEASTMSL5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
CDC91_YEASTGAB1genetic
27708008
GPI15_YEASTGPI15genetic
27708008
TRM6_YEASTGCD10genetic
27708008
RPC6_YEASTRPC34genetic
27708008
RPC1_YEASTRPO31genetic
27708008
DED1_YEASTDED1genetic
27708008
RPAB3_YEASTRPB8genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
GPN2_YEASTGPN2genetic
27708008
TFC8_YEASTTFC8genetic
27708008
PSB5_YEASTPRE2genetic
27708008
STX8_YEASTSYN8genetic
27708008
SWD1_YEASTSWD1genetic
27708008
SIF2_YEASTSIF2genetic
27708008
CS111_YEASTCOS111genetic
27708008
CHK1_YEASTCHK1genetic
27708008
SNT1_YEASTSNT1genetic
27708008
ATG15_YEASTATG15genetic
27708008
HSP78_YEASTHSP78genetic
27708008
SDC1_YEASTSDC1genetic
27708008
ATC5_YEASTDNF1genetic
27708008
BUD27_YEASTBUD27genetic
27708008
TFS2_YEASTDST1genetic
27708008
MAN1_YEASTAMS1genetic
27708008
YG2G_YEASTYGR079Wgenetic
27708008
REXO1_YEASTRNH70genetic
27708008
AIM18_YEASTAIM18genetic
27708008
CSK21_YEASTCKA1genetic
27708008
HOS4_YEASTHOS4genetic
27708008
IST3_YEASTIST3genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
UBL1_YEASTYUH1genetic
27708008
MUD2_YEASTMUD2genetic
27708008
MBR1_YEASTMBR1genetic
27708008
XPOT_YEASTLOS1genetic
27708008
SA190_YEASTSAP190genetic
27708008
SET3_YEASTSET3genetic
27708008
BRE2_YEASTBRE2genetic
27708008
UBR2_YEASTUBR2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
VPS38_YEASTVPS38genetic
27708008
SEI1_YEASTFLD1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
RIT1_YEASTRIT1genetic
27708008
CBPY_YEASTPRC1genetic
27708008
GAS1_YEASTGAS1genetic
27708008
PET8_YEASTPET8genetic
27708008
MKS1_YEASTMKS1genetic
27708008
MKT1_YEASTMKT1genetic
27708008
EAF7_YEASTEAF7genetic
27708008
SWM2_YEASTSWM2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
PSK2_YEASTPSK2genetic
27708008
MET22_YEASTMET22genetic
27708008
IES4_YEASTIES4genetic
27708008
RUD3_YEASTRUD3genetic
27708008
SNU66_YEASTSNU66genetic
27708008
DGK1_YEASTDGK1genetic
27708008
LDB19_YEASTLDB19genetic
27708008
LGE1_YEASTLGE1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
RU2A_YEASTLEA1genetic
27708008
YP084_YEASTYPR084Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPC4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119; SER-137; SER-138;SER-224 AND THR-232, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND THR-228, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224; THR-228 ANDTHR-232, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-182; SER-224;THR-228 AND THR-232, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-232, AND MASSSPECTROMETRY.

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