| UniProt ID | MMM1_YEAST | |
|---|---|---|
| UniProt AC | P41800 | |
| Protein Name | Maintenance of mitochondrial morphology protein 1 {ECO:0000255|HAMAP-Rule:MF_03103} | |
| Gene Name | MMM1 {ECO:0000255|HAMAP-Rule:MF_03103} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 426 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein . The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to |
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| Protein Description | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. [PubMed: 19556461 Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria] | |
| Protein Sequence | MTDSENESTETDSLMTFDDYISKELPEHLQRLIMENLKGSTTNDLKQTSNNSEFNVSKNGSFKGLDDAIQALQMQSVLHPSSLGSLATSSKFSGWSFAQGFFVGQLSIVLLFIFFLKFFIFSDEPSKSKNPKPAASRHRSKFKEYPFISREFLTSLVRKGAKQHYELNEEAENEHLQELALILEKTYYNVDVHPAESLDWFNVLVAQIIQQFRSEAWHRDNILHSLNDFIGRKSPDLPEYLDTIKITELDTGDDFPIFSNCRIQYSPNSGNKKLEAKIDIDLNDHLTLGVETKLLLNYPKPGIAALPINLVVSIVRFQACLTVSLTNAEEFASTSNGSSSENGMEGNSGYFLMFSFSPEYRMEFEIKSLIGSRSKLENIPKIGSVIEYQIKKWFVERCVEPRFQFVRLPSMWPRSKNTREEKPTEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | N-linked_Glycosylation | --MTDSENESTETDS --CCCCCCCCCCCCC | 53.09 | - | |
| 49 | Phosphorylation | TNDLKQTSNNSEFNV CCCHHHCCCCCCEEE | 31.36 | 27017623 | |
| 50 | N-linked_Glycosylation | NDLKQTSNNSEFNVS CCHHHCCCCCCEEEC | 60.48 | - | |
| 55 | N-linked_Glycosylation | TSNNSEFNVSKNGSF CCCCCCEEECCCCCC | 32.85 | - | |
| 57 | Phosphorylation | NNSEFNVSKNGSFKG CCCCEEECCCCCCCC | 22.85 | 27017623 | |
| 59 | N-linked_Glycosylation | SEFNVSKNGSFKGLD CCEEECCCCCCCCHH | 43.78 | - | |
| 61 | Phosphorylation | FNVSKNGSFKGLDDA EEECCCCCCCCHHHH | 32.93 | 27017623 | |
| 143 | Acetylation | SRHRSKFKEYPFISR HHCHHHCHHCCCCCH | 61.14 | 24489116 | |
| 155 | Phosphorylation | ISREFLTSLVRKGAK CCHHHHHHHHHHHHH | 27.32 | 30377154 | |
| 233 | Ubiquitination | LNDFIGRKSPDLPEY HHHHCCCCCCCHHHH | 62.21 | 23749301 | |
| 422 | Ubiquitination | SKNTREEKPTEL--- CCCCCCCCCCCC--- | 53.11 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MMM1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MMM1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MMM1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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