CWC2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CWC2_YEAST
• UniProt AC: Q12046
• Protein Name: Pre-mRNA-splicing factor CWC2
• Gene Name: CWC2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 339
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the "nineteen complex" NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Binds also to U1, U4, U5 and U6 snRNAs and to pre-mRNAs, in vitro. Is not required for the Prp2-mediated remodeling of the activated spliceosome..
• Protein Sequence: MTSWRDKSAKVQVKESELPSSIPAQTGLTFNIWYNKWSQGFAGNTRFVSPFALQPQLHSGKTRGDNDGQLFFCLFFAKGMCCLGPKCEYLHHIPDEEDIGKLALRTEVLDCFGREKFADYREDMGGIGSFRKKNKTLYVGGIDGALNSKHLKPAQIESRIRFVFSRLGDIDRIRYVESKNCGFVKFKYQANAEFAKEAMSNQTLLLPSDKEWDDRREGTGLLVKWANEDPDPAAQKRLQEELKLESLNMMVHLINNNTNSAGTEVNNKNNERLDRTFPEASVDNVKKRLLPLDNGMESDDFIEKLKKVKKNISRENISSKPSVGKLGGPLLDYLSSDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	ALQPQLHSGKTRGDN ECCCCCCCCCCCCCC	51.05	28889911
152	Acetylation	ALNSKHLKPAQIESR CCCCCCCCHHHHHHH	37.72	22865919
236	Acetylation	DPDPAAQKRLQEELK CCCHHHHHHHHHHHH	50.80	25381059
298	Phosphorylation	PLDNGMESDDFIEKL CCCCCCCCHHHHHHH	33.32	22369663
313	Phosphorylation	KKVKKNISRENISSK HHHHHHCCCCCCCCC	42.82	22369663
318	Phosphorylation	NISRENISSKPSVGK HCCCCCCCCCCCCCC	43.84	24961812
322	Phosphorylation	ENISSKPSVGKLGGP CCCCCCCCCCCCCCH	47.43	22369663
333	Phosphorylation	LGGPLLDYLSSDED- CCCHHHHHHCCCCC-	14.41	19795423
335	Phosphorylation	GPLLDYLSSDED--- CHHHHHHCCCCC---	29.52	19823750
336	Phosphorylation	PLLDYLSSDED---- HHHHHHCCCCC----	42.28	19823750

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CWC2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CWC2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CWC2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP17_YEAST	CDC40	physical	14690591
CEF1_YEAST	CEF1	physical	14690591
CLF1_YEAST	CLF1	physical	14690591
CWC22_YEAST	CWC22	physical	14690591
CWC23_YEAST	CWC23	physical	14690591
SLT11_YEAST	ECM2	physical	14690591
ISY1_YEAST	ISY1	physical	14690591
RU2A_YEAST	LEA1	physical	14690591
PRP19_YEAST	PRP19	physical	14690591
PRP43_YEAST	PRP43	physical	14690591
PRP45_YEAST	PRP45	physical	14690591
PRP46_YEAST	PRP46	physical	14690591
PRP8_YEAST	PRP8	physical	14690591
RSMB_YEAST	SMB1	physical	14690591
SMD1_YEAST	SMD1	physical	14690591
SMD3_YEAST	SMD3	physical	14690591
SN309_YEAST	SNT309	physical	14690591
SN114_YEAST	SNU114	physical	14690591
SYF1_YEAST	SYF1	physical	14690591
SYF2_YEAST	SYF2	physical	14690591
CWC16_YEAST	YJU2	physical	14690591
NTR2_YEAST	NTR2	physical	14690591
SP382_YEAST	SPP382	physical	14690591
BRR2_YEAST	BRR2	physical	14690591
CEF1_YEAST	CEF1	physical	11884590
BRR2_YEAST	BRR2	physical	11884590
PRP17_YEAST	CDC40	physical	11884590
CLF1_YEAST	CLF1	physical	11884590
BUD31_YEAST	BUD31	physical	11884590
CWC15_YEAST	CWC15	physical	11884590
CWC16_YEAST	YJU2	physical	11884590
CWC21_YEAST	CWC21	physical	11884590
CWC24_YEAST	CWC24	physical	11884590
CWC25_YEAST	CWC25	physical	11884590
CWC26_YEAST	BUD13	physical	11884590
SLT11_YEAST	ECM2	physical	11884590
IST2_YEAST	IST2	physical	11884590
RU2A_YEAST	LEA1	physical	11884590
MSL1_YEAST	MSL1	physical	11884590
NTC20_YEAST	NTC20	physical	11884590
ISY1_YEAST	ISY1	physical	11884590
PRP19_YEAST	PRP19	physical	11884590
PRP45_YEAST	PRP45	physical	11884590
PRP46_YEAST	PRP46	physical	11884590
PRP8_YEAST	PRP8	physical	11884590
SLU7_YEAST	SLU7	physical	11884590
RSMB_YEAST	SMB1	physical	11884590
SMD1_YEAST	SMD1	physical	11884590
SMD2_YEAST	SMD2	physical	11884590
SMD3_YEAST	SMD3	physical	11884590
RUXF_YEAST	SMX3	physical	11884590
SN309_YEAST	SNT309	physical	11884590
SN114_YEAST	SNU114	physical	11884590
SPP2_YEAST	SPP2	physical	11884590
SYF1_YEAST	SYF1	physical	11884590
SYF2_YEAST	SYF2	physical	11884590
PRP19_YEAST	PRP19	physical	12088152
PRP19_YEAST	PRP19	physical	10092627
BRR2_YEAST	BRR2	physical	16429126
CWC22_YEAST	CWC22	physical	16429126
PABP_YEAST	PAB1	physical	16429126
PRP8_YEAST	PRP8	physical	16429126
SN114_YEAST	SNU114	physical	16429126
SP382_YEAST	SPP382	physical	16429126
PRP17_YEAST	CDC40	physical	16429126
PRP19_YEAST	PRP19	physical	16429126
PRP46_YEAST	PRP46	physical	16429126
RSE1_YEAST	RSE1	physical	16429126
CLF1_YEAST	CLF1	physical	16429126
NCBP1_YEAST	STO1	physical	16429126
SYF1_YEAST	SYF1	physical	16429126
PRP19_YEAST	PRP19	physical	18719252
PRP8_YEAST	PRP8	physical	19016306
PRP22_YEAST	PRP22	physical	19016306
SYF1_YEAST	SYF1	physical	19016306
PRP19_YEAST	PRP19	physical	19016306
PRP46_YEAST	PRP46	physical	19016306
PRP45_YEAST	PRP45	physical	19016306
BRR2_YEAST	BRR2	physical	19016306
CLF1_YEAST	CLF1	physical	19016306
ACT_YEAST	ACT1	physical	19435883
RL28_YEAST	RPL28	physical	19435883
RS10B_YEAST	RPS10B	physical	19435883
PRP19_YEAST	PRP19	physical	20462492
ISY1_YEAST	ISY1	genetic	24848011
SPP2_YEAST	SPP2	physical	25561498
PRP2_YEAST	PRP2	physical	25561498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.