| UniProt ID | SP382_YEAST | |
|---|---|---|
| UniProt AC | Q06411 | |
| Protein Name | Pre-mRNA-splicing factor SPP382 | |
| Gene Name | SPP382 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 708 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.. | |
| Protein Sequence | MEDSDSNTDKKFFFKKRRIDSYNYSDEEDNNSSMNSDMTYTNDALKTSSGNAPTISKLTKTYGIGAKLLSSMGYVAGKGLGKDGSGITTPIETQSRPMHNAGLGMFSNTNSSNYHSENEDYLSSEDEVVEGIEQVKFNKTSTEVLGEALLNDSGDMTIVRTLRELRLAGVQLPESILKELDPLNAVPKPKKDVVVEILQELLGIEKSLEAIRQRTSPLEVQVKEYYGQERLLSELEVTLRDESKHVSLYDKIGAILKLSDDELIDRLTSCLLRKELLIEFDLDHLEKPNDILDELTQIIELLAYRMDTTSKFLNRTQTTIFKVIYPKLKKFWEGFDMTKSKIDSAITLLLDFQQVLSFIGCKEHIMEEFVYPKLLQELDNWELHDEVDHVSPRIWVLDFMVLIDDKIKDTIVDKIEAKFFAYCKNWYHRESFCITNSDIIFIKELICERRYYKILCKEFLPKFLDELWERHNDPIYELEDWKEKQEWKEKDSGFFYFMKKLRSYTHYFHPKQYELMMRGTFNNINKILYQWHLYSTVEDLHKSKWWLNWLMNTVFEHSLPTEIELSEIRKSYNIFAMSHRYHLDKSTLDEDFDLRQGLRNLMETQVIDDISQSEQEPTYTVQNIPLGKVSSSFKDVVEDYCLEKGYLISKIPNRYTQLPYGRDQDCIVPLFEIRNGKKKMEVALKHDILWVEDSSGTFKPIYLWALDL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MEDSDSNTDKK ----CCCCCCCCCCC | 29.63 | 28889911 | |
| 6 | Phosphorylation | --MEDSDSNTDKKFF --CCCCCCCCCCCHH | 45.65 | 30377154 | |
| 8 | Phosphorylation | MEDSDSNTDKKFFFK CCCCCCCCCCCHHEE | 53.82 | 30377154 | |
| 21 | Phosphorylation | FKKRRIDSYNYSDEE EEECCCCCCCCCCCC | 16.95 | 19823750 | |
| 22 | Phosphorylation | KKRRIDSYNYSDEED EECCCCCCCCCCCCC | 17.86 | 19823750 | |
| 24 | Phosphorylation | RRIDSYNYSDEEDNN CCCCCCCCCCCCCCC | 14.85 | 19823750 | |
| 25 | Phosphorylation | RIDSYNYSDEEDNNS CCCCCCCCCCCCCCC | 34.60 | 23749301 | |
| 32 | Phosphorylation | SDEEDNNSSMNSDMT CCCCCCCCCCCCCCE | 36.90 | 19823750 | |
| 33 | Phosphorylation | DEEDNNSSMNSDMTY CCCCCCCCCCCCCEE | 24.89 | 19823750 | |
| 36 | Phosphorylation | DNNSSMNSDMTYTND CCCCCCCCCCEECCC | 21.81 | 19823750 | |
| 39 | Phosphorylation | SSMNSDMTYTNDALK CCCCCCCEECCCHHH | 31.98 | 19823750 | |
| 40 | Phosphorylation | SMNSDMTYTNDALKT CCCCCCEECCCHHHH | 9.26 | 19823750 | |
| 41 | Phosphorylation | MNSDMTYTNDALKTS CCCCCEECCCHHHHC | 19.91 | 19823750 | |
| 49 | Phosphorylation | NDALKTSSGNAPTIS CCHHHHCCCCCCCHH | 41.10 | 30377154 | |
| 57 | Acetylation | GNAPTISKLTKTYGI CCCCCHHHHHHHHCC | 57.22 | 22865919 | |
| 78 | Acetylation | SMGYVAGKGLGKDGS HCCCCCCCCCCCCCC | 41.02 | 24489116 | |
| 82 | Acetylation | VAGKGLGKDGSGITT CCCCCCCCCCCCCCC | 65.05 | 25381059 | |
| 89 | Phosphorylation | KDGSGITTPIETQSR CCCCCCCCCCCCCCC | 21.98 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SP382_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SP382_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SP382_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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