| UniProt ID | CUL3_YEAST | |
|---|---|---|
| UniProt AC | P53202 | |
| Protein Name | Cullin-3 | |
| Gene Name | CUL3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 744 | |
| Subcellular Localization | ||
| Protein Description | Component of a ubiquitin-protein ligase. Together with ELA1 is required for polyubiquitination and degradation of RBP1.. | |
| Protein Sequence | MITNKKIKISVPEKLGLSEESFEESWETVKYAIDHIYSDDMADLSFEQVYKTIYTIVLNKKGPILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKPNRCMEVYDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLIGMMETLHDNRDSFFLTDFEPVLISATEEYYNKAIDIELLTPIESLEKIRKLRQFESMLDSSFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAMVISNGKLLQEIYDLSSEEKYRVTVIESIKSYINKNAINIPFNEGNRKKGQNAITWSSEIVELYRSQHSFLESIDFGSVRLNNLTGDVSNAILGDVFSMYFSKEGALPSEYLSTYVDHCMKRTKEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRSLVEIEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQHSTINSIEYLSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMSTIPRCKILKKSSSSGNMKFSVNYFFSSPNRKVKVPVIACPLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYHYLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 624 | Phosphorylation | RCKILKKSSSSGNMK CEEEEEECCCCCCCE | 33.59 | 27017623 | |
| 625 | Phosphorylation | CKILKKSSSSGNMKF EEEEEECCCCCCCEE | 37.09 | 27017623 | |
| 626 | Phosphorylation | KILKKSSSSGNMKFS EEEEECCCCCCCEEE | 49.72 | 27017623 | |
| 627 | Phosphorylation | ILKKSSSSGNMKFSV EEEECCCCCCCEEEE | 35.81 | 27017623 | |
| 688 | Neddylation | AIIVRIMKTEGKLSH HHHHHHHHCCCCCCH | 40.84 | - | |
| 688 | Ubiquitination | AIIVRIMKTEGKLSH HHHHHHHHCCCCCCH | 40.84 | 23749301 | |
| 692 | Ubiquitination | RIMKTEGKLSHQQLL HHHHCCCCCCHHHHH | 40.35 | 22817900 | |
| 694 | Phosphorylation | MKTEGKLSHQQLLER HHCCCCCCHHHHHHH | 23.80 | 28889911 | |
| 718 | Ubiquitination | SLTPSILKRSIQLLI CCCHHHHHHHHHHHH | 42.29 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CUL3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CUL3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CUL3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
