| UniProt ID | SCH9_YEAST | |
|---|---|---|
| UniProt AC | P11792 | |
| Protein Name | Serine/threonine-protein kinase SCH9 | |
| Gene Name | SCH9 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 824 | |
| Subcellular Localization | ||
| Protein Description | Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity. [PubMed: 20702584 Regulates ribosome biogenesis, translation initiation, and entry into stationary phase in a TORC1-dependent manner] | |
| Protein Sequence | MMNFFTSKSSNQDTGFSSQHQHPNGQNNGNNNSSTAGNDNGYPCKLVSSGPCASSNNGALFTNFTLQTATPTTAISQDLYAMGTTGITSENALFQMKSMNNGISSVNNNNSNTPTIITTSQEETNAGNVHGDTGGNSLQNSEDDNFSSSSTTKCLLSSTSSLSINQREAAAAAYGPDTDIPRGKLEVTIIEARDLVTRSKDSQPYVVCTFESSEFISNGPESLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQLPSIKEHLKKKPLYTHRSSSQLDQLNSCSSVTDPSKRSSNSSSGSSNGPKNDSSHPIWHHKTTFDVLGSHSELDISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDEVVSGDILIKWTYKQTKKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMMTATPLSPAMQAKFAGFTFVDESAIDEHVNNNRKFLQNSYFMEPGSFIPGNPNLPPDEDVIDDDGDEDINDGFNQEKNMNNSHSQMDFDGDQHMDDEFVSGRFEI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 157 | Phosphorylation | STTKCLLSSTSSLSI CHHHHHHCCCCCCCC | 20.72 | 22369663 | |
| 158 | Phosphorylation | TTKCLLSSTSSLSIN HHHHHHCCCCCCCCC | 32.07 | 22369663 | |
| 159 | Phosphorylation | TKCLLSSTSSLSINQ HHHHHCCCCCCCCCH | 20.96 | 22369663 | |
| 160 | Phosphorylation | KCLLSSTSSLSINQR HHHHCCCCCCCCCHH | 31.09 | 22369663 | |
| 161 | Phosphorylation | CLLSSTSSLSINQRE HHHCCCCCCCCCHHH | 26.65 | 22369663 | |
| 163 | Phosphorylation | LSSTSSLSINQREAA HCCCCCCCCCHHHHH | 22.80 | 22369663 | |
| 284 | Phosphorylation | HLKKKPLYTHRSSSQ HHHCCCCCCCCCHHH | 14.72 | 19823750 | |
| 285 | Phosphorylation | LKKKPLYTHRSSSQL HHCCCCCCCCCHHHH | 20.63 | 21440633 | |
| 288 | Phosphorylation | KPLYTHRSSSQLDQL CCCCCCCCHHHHHHH | 27.08 | 22369663 | |
| 289 | Phosphorylation | PLYTHRSSSQLDQLN CCCCCCCHHHHHHHH | 23.28 | 22369663 | |
| 290 | Phosphorylation | LYTHRSSSQLDQLNS CCCCCCHHHHHHHHC | 35.69 | 22369663 | |
| 297 | Phosphorylation | SQLDQLNSCSSVTDP HHHHHHHCCCCCCCC | 24.78 | 28889911 | |
| 299 | Phosphorylation | LDQLNSCSSVTDPSK HHHHHCCCCCCCCCC | 27.88 | 22890988 | |
| 300 | Phosphorylation | DQLNSCSSVTDPSKR HHHHCCCCCCCCCCC | 33.10 | 23749301 | |
| 302 | Phosphorylation | LNSCSSVTDPSKRSS HHCCCCCCCCCCCCC | 44.11 | 23749301 | |
| 311 | Phosphorylation | PSKRSSNSSSGSSNG CCCCCCCCCCCCCCC | 28.03 | 27214570 | |
| 312 | Phosphorylation | SKRSSNSSSGSSNGP CCCCCCCCCCCCCCC | 42.86 | 23749301 | |
| 313 | Phosphorylation | KRSSNSSSGSSNGPK CCCCCCCCCCCCCCC | 42.38 | 23749301 | |
| 315 | Phosphorylation | SSNSSSGSSNGPKND CCCCCCCCCCCCCCC | 23.68 | 23749301 | |
| 316 | Phosphorylation | SNSSSGSSNGPKNDS CCCCCCCCCCCCCCC | 49.70 | 23749301 | |
| 320 | Ubiquitination | SGSSNGPKNDSSHPI CCCCCCCCCCCCCCC | 74.84 | 17644757 | |
| 331 | Ubiquitination | SHPIWHHKTTFDVLG CCCCCCCCCEEEECC | 36.05 | 17644757 | |
| 420 | Ubiquitination | EVLRLLGKGTFGQVY HHHHHHCCCCCCEEE | 55.54 | 23749301 | |
| 441 | Ubiquitination | TQRIYAMKVLSKKVI HHHHHEEEECCCCEE | 31.67 | 23749301 | |
| 450 | Ubiquitination | LSKKVIVKKNEIAHT CCCCEEEEHHHHHHH | 38.46 | 17644757 | |
| 451 | Ubiquitination | SKKVIVKKNEIAHTI CCCEEEEHHHHHHHC | 49.25 | 17644757 | |
| 466 | Phosphorylation | GERNILVTTASKSSP CCCCEEEEECCCCCC | 17.13 | 28889911 | |
| 471 | Phosphorylation | LVTTASKSSPFIVGL EEEECCCCCCEEEEE | 40.52 | 29734811 | |
| 472 | Phosphorylation | VTTASKSSPFIVGLK EEECCCCCCEEEEEE | 27.80 | 21440633 | |
| 540 | Ubiquitination | DIVYRDLKPENILLD CCEECCCCHHHEEEC | 55.35 | 17644757 | |
| 561 | Ubiquitination | LCDFGLSKADLKDRT ECCCCCCHHHHCCCC | 51.46 | 17644757 | |
| 568 | Phosphorylation | KADLKDRTNTFCGTT HHHHCCCCCCCCCCH | 49.06 | 22369663 | |
| 570 | Phosphorylation | DLKDRTNTFCGTTEY HHCCCCCCCCCCHHH | 21.49 | 22369663 | |
| 574 | Phosphorylation | RTNTFCGTTEYLAPE CCCCCCCCHHHHCHH | 20.03 | 22369663 | |
| 575 | Phosphorylation | TNTFCGTTEYLAPEL CCCCCCCHHHHCHHH | 14.12 | 20377248 | |
| 577 | Phosphorylation | TFCGTTEYLAPELLL CCCCCHHHHCHHHHH | 13.18 | 25521595 | |
| 587 | Phosphorylation | PELLLDETGYTKMVD HHHHHCCCCCCCHHC | 34.84 | 28889911 | |
| 589 | Phosphorylation | LLLDETGYTKMVDFW HHHCCCCCCCHHCHH | 15.59 | 28889911 | |
| 590 | Phosphorylation | LLDETGYTKMVDFWS HHCCCCCCCHHCHHH | 17.63 | 28889911 | |
| 623 | Ubiquitination | NNQKMYQKIAFGKVK CCHHHHHHHHHCCCC | 20.65 | 23749301 | |
| 645 | Acetylation | QEGRSFVKGLLNRNP HHHHHHHHHHHHCCC | 41.66 | 24489116 | |
| 680 | Ubiquitination | DIDWEALKQKKIPPP CCCHHHHHCCCCCCC | 68.09 | 17644757 | |
| 682 | Ubiquitination | DWEALKQKKIPPPFK CHHHHHCCCCCCCCC | 51.59 | 17644757 | |
| 683 | Ubiquitination | WEALKQKKIPPPFKP HHHHHCCCCCCCCCC | 58.93 | 17644757 | |
| 709 | Phosphorylation | DPEFTTASTSYMNKH CCCCCCCCCHHHCCC | 18.78 | 24961812 | |
| 710 | Phosphorylation | PEFTTASTSYMNKHQ CCCCCCCCHHHCCCC | 22.78 | 24961812 | |
| 711 | Phosphorylation | EFTTASTSYMNKHQP CCCCCCCHHHCCCCC | 21.64 | 15470109 | |
| 721 | Phosphorylation | NKHQPMMTATPLSPA CCCCCCCCCCCCCHH | 22.56 | 21551504 | |
| 723 | Phosphorylation | HQPMMTATPLSPAMQ CCCCCCCCCCCHHHH | 18.65 | 17330950 | |
| 726 | Phosphorylation | MMTATPLSPAMQAKF CCCCCCCCHHHHHHH | 16.30 | 25521595 | |
| 737 | Phosphorylation | QAKFAGFTFVDESAI HHHHCCCEEECHHHH | 23.10 | 15470109 | |
| 742 | Phosphorylation | GFTFVDESAIDEHVN CCEEECHHHHHHHHH | 26.51 | 23749301 | |
| 758 | Phosphorylation | NRKFLQNSYFMEPGS CCHHHHHCCCCCCCC | 13.54 | 15470109 | |
| 765 | Phosphorylation | SYFMEPGSFIPGNPN CCCCCCCCCCCCCCC | 30.62 | 15470109 | |
| 801 | Phosphorylation | QEKNMNNSHSQMDFD CCCCCCCCCCCCCCC | 21.36 | 28889911 | |
| 803 | Phosphorylation | KNMNNSHSQMDFDGD CCCCCCCCCCCCCCC | 27.33 | 28889911 | |
| 819 | Phosphorylation | HMDDEFVSGRFEI-- CCCCCCCCCCCCC-- | 29.58 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 570 | T | Phosphorylation | Kinase | PKH1 | Q03407 | Uniprot |
| 570 | T | Phosphorylation | Kinase | PKH2 | Q12236 | Uniprot |
| 711 | S | Phosphorylation | Kinase | TORC1 | - | Uniprot |
| 723 | T | Phosphorylation | Kinase | TOR2 | P32600 | GPS |
| 723 | T | Phosphorylation | Kinase | TORC1 | - | Uniprot |
| 726 | S | Phosphorylation | Kinase | TOR2 | P32600 | GPS |
| 726 | S | Phosphorylation | Kinase | TORC1 | - | Uniprot |
| 737 | T | Phosphorylation | Kinase | TOR2 | P32600 | GPS |
| 737 | T | Phosphorylation | Kinase | TORC1 | - | Uniprot |
| 758 | S | Phosphorylation | Kinase | TOR2 | P32600 | GPS |
| 758 | S | Phosphorylation | Kinase | TORC1 | - | Uniprot |
| 765 | S | Phosphorylation | Kinase | TOR2 | P32600 | GPS |
| 765 | S | Phosphorylation | Kinase | TORC1 | - | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCH9_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCH9_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; SER-288; SER-289;THR-568; THR-570; TYR-577; SER-726 AND SER-801, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-723 AND SER-726, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-568 AND THR-570, ANDMASS SPECTROMETRY. | |
