| UniProt ID | UTP22_YEAST | |
|---|---|---|
| UniProt AC | P53254 | |
| Protein Name | U3 small nucleolar RNA-associated protein 22 | |
| Gene Name | UTP22 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1237 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.. | |
| Protein Sequence | MATSVKRKASETSDQNIVKVQKKHSTQDSTTDNGSKENDHSSQAINERTVPEQENDESDTSPESNEVATNTAATRHNGKVTATESYDIHIARETAELFKSNIFKLQIDELLEQVKLKQKHVLKVEKFLHKLYDILQEIPDWEEKSLAEVDSFFKNKIVSVPFVDPKPIPQNTNYKFNYKKPDISLIGSFALKAGIYQPNGSSIDTLLTMPKELFEKKDFLNFRCLHKRSVYLAYLTHHLLILLKKDKLDSFLQLEYSYFDNDPLLPILRISCSKPTGDSLSDYNFYKTRFSINLLIGFPYKVFEPKKLLPNRNCIRIAQESKEQSLPATPLYNFSVLSSSTHENYLKYLYKTKKQTESFVEATVLGRLWLQQRGFSSNMSHSGSLGGFGTFEFTILMAALLNGGGINSNKILLHGFSSYQLFKGVIKYLATMDLCHDGHLQFHSNPENSSSSPASKYIDEGFQTPTLFDKSTKVNILTKMTVSSYQILKEYAGETLRMLNNVVQDQFSNIFLTNISRFDNLKYDLCYDVQLPLGKYNNLETSLAATFGSMERVKFITLENFLAHKITNVARYALGDRIKYIQIEMVGQKSDFPITKRKVYSNTGGNHFNFDFVRVKLIVNPSECDKLVTKGPAHSETMSTEAAVFKNFWGIKSSLRRFKDGSITHCCVWSTSSSEPIISSIVNFALQKHVSKKAQISNETIKKFHNFLPLPNLPSSAKTSVLNLSSFFNLKKSFDDLYKIIFQMKLPLSVKSILPVGSAFRYTSLCQPVPFAYSDPDFFQDVILEFETSPKWPDEITSLEKAKTAFLLKIQEELSANSSTYRSFFSRDESIPYNLEIVTLNILTPEGYGFKFRVLTERDEILYLRAIANARNELKPELEATFLKFTAKYLASVRHTRTLENISHSYQFYSPVVRLFKRWLDTHLLLGHITDELAELIAIKPFVDPAPYFIPGSLENGFLKVLKFISQWNWKDDPLILDLVKPEDDIRDTFETSIGAGSELDSKTMKKLSERLTLAQYKGIQMNFTNLRNSDPNGTHLQFFVASKNDPSGILYSSGIPLPIATRLTALAKVAVNLLQTHGLNQQTINLLFTPGLKDYDFVVDLRTPIGLKSSCGILSATEFKNITNDQAPSNFPENLNDLSEKMDPTYQLVKYLNLKYKNSLILSSRKYIGVNGGEKGDKNVITGLIKPLFKGAHKFRVNLDCNVKPVDDENVILNKEAIFHEIAAFGNDMVINFETD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | TSVKRKASETSDQNI CCCCCCCCCCCCCCC | 44.43 | 25521595 | |
| 12 | Phosphorylation | VKRKASETSDQNIVK CCCCCCCCCCCCCEE | 34.80 | 22369663 | |
| 13 | Phosphorylation | KRKASETSDQNIVKV CCCCCCCCCCCCEEE | 32.90 | 22369663 | |
| 25 | Phosphorylation | VKVQKKHSTQDSTTD EEEEECCCCCCCCCC | 36.32 | 28889911 | |
| 31 | Phosphorylation | HSTQDSTTDNGSKEN CCCCCCCCCCCCCCC | 31.27 | 21082442 | |
| 35 | Phosphorylation | DSTTDNGSKENDHSS CCCCCCCCCCCCCCC | 42.95 | 28889911 | |
| 41 | Phosphorylation | GSKENDHSSQAINER CCCCCCCCCHHHHHC | 27.32 | 27214570 | |
| 42 | Phosphorylation | SKENDHSSQAINERT CCCCCCCCHHHHHCC | 21.88 | 23749301 | |
| 49 | Phosphorylation | SQAINERTVPEQEND CHHHHHCCCCCCCCC | 33.94 | 21551504 | |
| 58 | Phosphorylation | PEQENDESDTSPESN CCCCCCCCCCCCCCC | 49.40 | 22369663 | |
| 60 | Phosphorylation | QENDESDTSPESNEV CCCCCCCCCCCCCCH | 56.30 | 22369663 | |
| 61 | Phosphorylation | ENDESDTSPESNEVA CCCCCCCCCCCCCHH | 31.49 | 22369663 | |
| 64 | Phosphorylation | ESDTSPESNEVATNT CCCCCCCCCCHHHCC | 41.49 | 22890988 | |
| 69 | Phosphorylation | PESNEVATNTAATRH CCCCCHHHCCCCCEE | 37.97 | 22890988 | |
| 71 | Phosphorylation | SNEVATNTAATRHNG CCCHHHCCCCCEECC | 17.20 | 22890988 | |
| 74 | Phosphorylation | VATNTAATRHNGKVT HHHCCCCCEECCEEE | 29.96 | 22890988 | |
| 154 | Acetylation | AEVDSFFKNKIVSVP HHHHHHHHCCEEECE | 56.15 | 24489116 | |
| 159 | Phosphorylation | FFKNKIVSVPFVDPK HHHCCEEECEECCCC | 27.78 | 21551504 | |
| 166 | Acetylation | SVPFVDPKPIPQNTN ECEECCCCCCCCCCC | 51.63 | 24489116 | |
| 287 | Acetylation | LSDYNFYKTRFSINL HHHCCCCCCEEEEEE | 29.14 | 24489116 | |
| 321 | Phosphorylation | CIRIAQESKEQSLPA CHHHCHHHHHCCCCC | 29.43 | 28747907 | |
| 325 | Phosphorylation | AQESKEQSLPATPLY CHHHHHCCCCCCCCC | 37.09 | 28747907 | |
| 332 | Phosphorylation | SLPATPLYNFSVLSS CCCCCCCCCEECCCC | 18.50 | 28747907 | |
| 340 | Phosphorylation | NFSVLSSSTHENYLK CEECCCCCCCHHHHH | 30.33 | 28747907 | |
| 341 | Phosphorylation | FSVLSSSTHENYLKY EECCCCCCCHHHHHH | 34.85 | 28747907 | |
| 376 | Phosphorylation | WLQQRGFSSNMSHSG HHHHCCCCCCCCCCC | 24.51 | 30377154 | |
| 377 | Phosphorylation | LQQRGFSSNMSHSGS HHHCCCCCCCCCCCC | 34.00 | 30377154 | |
| 408 | Phosphorylation | LNGGGINSNKILLHG HCCCCCCCCCEEECC | 37.26 | 30377154 | |
| 470 | Acetylation | QTPTLFDKSTKVNIL CCCCCCCCCCCCEEE | 53.33 | 24489116 | |
| 536 | Phosphorylation | VQLPLGKYNNLETSL EECCCCCCCCHHHHH | 13.90 | 27017623 | |
| 541 | Phosphorylation | GKYNNLETSLAATFG CCCCCHHHHHHHHHC | 32.01 | 27017623 | |
| 554 | Acetylation | FGSMERVKFITLENF HCCHHHEEEEEHHHH | 36.95 | 24489116 | |
| 565 | Acetylation | LENFLAHKITNVARY HHHHHHHHHHHHHHH | 45.69 | 24489116 | |
| 626 | Acetylation | VNPSECDKLVTKGPA ECHHHHHHHEECCCC | 57.42 | 24489116 | |
| 662 | Phosphorylation | LRRFKDGSITHCCVW HHHCCCCCEEEEEEE | 34.15 | 19779198 | |
| 664 | Phosphorylation | RFKDGSITHCCVWST HCCCCCEEEEEEEEC | 15.57 | 19779198 | |
| 670 | Phosphorylation | ITHCCVWSTSSSEPI EEEEEEEECCCCCCH | 9.67 | 19779198 | |
| 998 | Phosphorylation | ETSIGAGSELDSKTM HHCCCCCCCCCHHHH | 34.16 | 27017623 | |
| 1002 | Phosphorylation | GAGSELDSKTMKKLS CCCCCCCHHHHHHHH | 42.52 | 27017623 | |
| 1004 | Phosphorylation | GSELDSKTMKKLSER CCCCCHHHHHHHHHH | 37.87 | 27017623 | |
| 1116 | Phosphorylation | KSSCGILSATEFKNI CCCCCCCCHHHCCCC | 31.09 | 27214570 | |
| 1158 | Methylation | KYLNLKYKNSLILSS HHHCCEECCEEEEEC | 38.17 | 20137074 | |
| 1160 | Phosphorylation | LNLKYKNSLILSSRK HCCEECCEEEEECCC | 16.79 | 28889911 | |
| 1164 | Phosphorylation | YKNSLILSSRKYIGV ECCEEEEECCCEEEC | 22.54 | 28889911 | |
| 1205 | Ubiquitination | VNLDCNVKPVDDENV EECCCCCCCCCCCCE | 25.90 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UTP22_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UTP22_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UTP22_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-42; THR-49;SER-58 AND THR-60, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; THR-12 AND SER-13,AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY. | |
