RRP7_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRP7_YEAST
• UniProt AC: P25368
• Protein Name: Ribosomal RNA-processing protein 7
• Gene Name: RRP7
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 297
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Plays an important role in the synthesis of 18S rRNA but is not required for the 5.8S and 25S pathway. Is necessary for the cleavage at site A2. Is required for efficient association of RPS27 with the pre-ribosomal particle..
• Protein Sequence: MGIEDISAMKNGFIVVPFKLPDHKALPKSQEASLHFMFAKRHQSSNSNESDCLFLVNLPLLSNIEHMKKFVGQLCGKYDTVSHVEELLYNDEFGLHEVDLSALTSDLMSSTDVNEKRYTPRNTALLKFVDAASINNCWNALKKYSNLHAKHPNELFEWTYTTPSFTTFVNFYKPLDIDYLKEDIHTHMAIFEQREAQAQEDVQSSIVDEDGFTLVVGKNTKSLNSIRKKILNKNPLSKHENKAKPISNIDKKAKKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKRKFNPYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
233	Acetylation	IRKKILNKNPLSKHE HHHHHHCCCCCCCCC	57.40	25381059
238	Acetylation	LNKNPLSKHENKAKP HCCCCCCCCCCCCCC	63.72	25381059
276	Acetylation	EINQLLSKFKEDQER HHHHHHHHHHHHHHH	61.50	24489116
278	Acetylation	NQLLSKFKEDQERIK HHHHHHHHHHHHHHH	65.21	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRP7_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRP7_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRP7_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS27A_YEAST	RPS27A	genetic	9271380
RS27B_YEAST	RPS27B	genetic	9271380
UTP22_YEAST	UTP22	physical	16554755
IFH1_YEAST	IFH1	physical	17452446
FHL1_YEAST	FHL1	physical	17452446
RL1D1_YEAST	UTP30	genetic	19061648
RIC1_YEAST	RIC1	genetic	19061648
EIF3J_YEAST	HCR1	genetic	19061648
TSR2_YEAST	TSR2	genetic	19061648
CBT1_YEAST	CBT1	genetic	19061648
MRT4_YEAST	MRT4	genetic	19061648
CSN11_YEAST	PCI8	genetic	19061648
NAM7_YEAST	NAM7	genetic	19061648
SYDM_YEAST	MSD1	genetic	19061648
NMD2_YEAST	NMD2	genetic	19061648
PWP2_YEAST	PWP2	physical	17515605
RRP5_YEAST	RRP5	physical	21724601
UTP10_YEAST	UTP10	physical	21724601
UTP22_YEAST	UTP22	physical	21724601
NAT10_YEAST	KRE33	physical	21724601
EF3A_YEAST	YEF3	physical	21724601
UTP21_YEAST	UTP21	physical	21724601
UTP13_YEAST	UTP13	physical	21724601
UTP4_YEAST	UTP4	physical	21724601
UTP17_YEAST	NAN1	physical	21724601
BFR2_YEAST	BFR2	physical	21724601
UTP8_YEAST	UTP8	physical	21724601
XRN2_YEAST	RAT1	physical	21724601
RRP9_YEAST	RRP9	physical	21724601
SSB1_YEAST	SSB1	physical	21724601
UTP7_YEAST	UTP7	physical	21724601
RCL1_YEAST	RCL1	physical	21724601
MRD1_YEAST	MRD1	physical	21724601
PWP2_YEAST	PWP2	physical	21724601
UTP12_YEAST	DIP2	physical	21724601
NOL10_YEAST	ENP2	physical	21724601
UTP9_YEAST	UTP9	physical	21724601
CBF5_YEAST	CBF5	physical	21724601
RL4A_YEAST	RPL4A	physical	21724601
RL4B_YEAST	RPL4B	physical	21724601
FBRL_YEAST	NOP1	physical	21724601
UTP22_YEAST	UTP22	physical	24130456
IFH1_YEAST	IFH1	physical	27818142
UTP22_YEAST	UTP22	physical	27818142
EMP46_YEAST	EMP46	genetic	27708008
NOP12_YEAST	NOP12	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
ESA1_YEAST	ESA1	genetic	27708008
CST9_YEAST	CST9	genetic	27708008
DOM34_YEAST	DOM34	genetic	27708008
RRP6_YEAST	RRP6	genetic	27708008
BUD21_YEAST	BUD21	genetic	27708008
SUR1_YEAST	SUR1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.