| UniProt ID | XRN2_YEAST | |
|---|---|---|
| UniProt AC | Q02792 | |
| Protein Name | 5'-3' exoribonuclease 2 | |
| Gene Name | RAT1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1006 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA, rRNA and small nucleolar RNA (snoRNA) precursors. May promote termination of transcription by RNA polymerase II via the recruitment of 3'-end processing factors to the poly(A) site and by the degradation of nascent RNA downstream of the poly(A) site.. | |
| Protein Sequence | MGVPSFFRWLSRKYPKIISPVLEEQPQIVDGVILPLDYSASNPNGELDNLYLDMNGIVHPCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRFRSARDAQIENEAREEIMRQREEVGEIIDDAVRNKKTWDSNAITPGTPFMDKLAAALRYWTAFKLATDPGWKNLQVIISDATVPGEGEHKIMNFIRSQRADPEYNPNTTHCIYGLDADLIFLGLATHEPHFKILREDVFAQDNRKRNNLKDTINMTEEEKQFLQKQNSEQPFLWLHINVLREYLSAELWVPGLPFTFDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWKVVLPKLKTYMTCDGVLNLPSVETLLQHLGSREGDIFKTRHIQEARKKEAFERRKAQKNMSKGQDRHPTVATEQLQMYDTQGNLAKGSWNLTTSDMVRLKKELMLANEGNEEAIAKVKQQSDKNNELMKDISKEEIDDAVSKANKTNFNLAEVMKQKIINKKHRLEKDNEEEEIAKDSKKVKTEKAESECDLDAEIKDEIVADVNDRENSETTEVSRDSPVHSTVNVSEGPKNGVFDTDEFVKLFEPGYHERYYTAKFHVTPQDIEQLRKDMVKCYIEGVAWVLMYYYQGCASWNWFYPYHYAPLATDFHGFSHLEIKFEEGTPFLPYEQLMSVLPAASGHALPKIFRSLMSEPDSEIIDFYPEEFPIDMNGKKMSWQGIALLPFIDQDRLLTAVRAQYPLLSDAERARNIRGEPVLLISNKNANYERFSKKLYSKENNNNNVVVKFQHFKSGLSGIVSKDVEGFELNGKIVCPIQGGSLPNLSTTLILKMSYRLIPLPSRNKSIILNGFIPSEPVLTAYDLDSIMYKYNNQNYSRRWNFGNDLKQNIVPVGPKGITQYKPRTGGYRAFFYFAELSRNNVQPAHNYGRNSYNSQPGFNNSRYDGGNNNYRQNSNYRNNNYSGNRNSGQYSGNSYSRNNKQSRYDNSRANRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 364 | Phosphorylation | VVLPKLKTYMTCDGV HHHHHHCCCCCCCCC | 29.03 | 27017623 | |
| 365 | Phosphorylation | VLPKLKTYMTCDGVL HHHHHCCCCCCCCCC | 6.72 | 27017623 | |
| 367 | Phosphorylation | PKLKTYMTCDGVLNL HHHCCCCCCCCCCCC | 9.31 | 27017623 | |
| 379 | Phosphorylation | LNLPSVETLLQHLGS CCCCCHHHHHHHHCC | 30.52 | 27017623 | |
| 386 | Phosphorylation | TLLQHLGSREGDIFK HHHHHHCCCCCCHHH | 33.25 | 27017623 | |
| 427 | Phosphorylation | DRHPTVATEQLQMYD CCCCCHHHHHHEEEE | 21.67 | 27017623 | |
| 435 | Phosphorylation | EQLQMYDTQGNLAKG HHHEEEECCCCCCCC | 22.38 | 27017623 | |
| 484 | Acetylation | DKNNELMKDISKEEI HHCCHHHHHCCHHHH | 65.61 | 22865919 | |
| 487 | Phosphorylation | NELMKDISKEEIDDA CHHHHHCCHHHHHHH | 44.11 | 27214570 | |
| 497 | Acetylation | EIDDAVSKANKTNFN HHHHHHHHHHHCCCC | 49.75 | 24489116 | |
| 500 | Acetylation | DAVSKANKTNFNLAE HHHHHHHHCCCCHHH | 50.10 | 24489116 | |
| 522 | Acetylation | NKKHRLEKDNEEEEI CCHHHHCCCCHHHHH | 71.14 | 22865919 | |
| 531 | Acetylation | NEEEEIAKDSKKVKT CHHHHHHHHCCCCCH | 69.10 | 22865919 | |
| 543 | Phosphorylation | VKTEKAESECDLDAE CCHHHHHHCCCCCHH | 48.67 | 22890988 | |
| 565 | Phosphorylation | DVNDRENSETTEVSR CCCCCCCCCCCEECC | 31.41 | 23607784 | |
| 571 | Phosphorylation | NSETTEVSRDSPVHS CCCCCEECCCCCCCE | 24.92 | 19779198 | |
| 574 | Phosphorylation | TTEVSRDSPVHSTVN CCEECCCCCCCEEEE | 27.93 | 25704821 | |
| 579 | Phosphorylation | RDSPVHSTVNVSEGP CCCCCCEEEECCCCC | 10.96 | 28889911 | |
| 789 | Phosphorylation | ERFSKKLYSKENNNN HHHHHHHHCCCCCCC | 26.95 | 19779198 | |
| 900 | Ubiquitination | WNFGNDLKQNIVPVG CCCCCCCHHCEEECC | 44.13 | 23749301 | |
| 900 | Acetylation | WNFGNDLKQNIVPVG CCCCCCCHHCEEECC | 44.13 | 24489116 | |
| 946 | Phosphorylation | HNYGRNSYNSQPGFN HHCCCCCCCCCCCCC | 23.53 | 19779198 | |
| 955 | Phosphorylation | SQPGFNNSRYDGGNN CCCCCCCCCCCCCCC | 33.06 | 30377154 | |
| 981 | Phosphorylation | NYSGNRNSGQYSGNS CCCCCCCCCCCCCCC | 24.84 | 28889911 | |
| 990 | Phosphorylation | QYSGNSYSRNNKQSR CCCCCCCCCCCCCCC | 28.49 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of XRN2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of XRN2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of XRN2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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