dbPTM

TEP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TEP1_YEAST
UniProt AC	P53916
Protein Name	Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
Gene Name	TEP1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	434
Subcellular Localization
Protein Description	May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels..
Protein Sequence	MREEGSELEMEKGFLKWKPVNLMKKILSLPMKKTKNDIGLRLDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFITHEKAAQEGISNEAVKFKFKFRLAKMTFLRPSSLITSESAIVTTKIQHYNDDRNALLTRKVVYSDIMAHECGGNMTFIFGRDYLTLENDCRIEFTLGTSKSKAASSIISWTSCASCWLNIYLETLMHIIKDDSSPDYFQVERLKRDEMLGTTISWQELDGFGELSTHGLKLFQALKLEWEII

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	VNLIVCSYPVNTYPK HHHHHHCCCCCCCCH	13.18	29650682
61	Phosphorylation	CSYPVNTYPKLLYRN HCCCCCCCCHHHHHC	7.99	29650682
135	Phosphorylation	NDGKIPISPIDLETR CCCCCCCCCCCCCCC	15.50	27214570
149	Phosphorylation	RTLVEEETNNVICER CHHCCHHHCCEECHH	35.06	28889911
277	Acetylation	KFKFRLAKMTFLRPS HHHHHEEECCCCCCH	42.96	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TEP1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TEP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TEP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLH3_YEAST	MLH3	physical	11805837
ILVB_YEAST	ILV2	physical	11805837
MLP2_YEAST	MLP2	physical	11805837
STE50_YEAST	STE50	genetic	19269370
BMH2_YEAST	BMH2	genetic	19269370
STE20_YEAST	STE20	genetic	19269370
LRP1_YEAST	LRP1	genetic	19269370
F26_YEAST	FBP26	genetic	19269370
ATG17_YEAST	ATG17	genetic	19269370
VPS71_YEAST	VPS71	genetic	19269370
CIN1_YEAST	CIN1	genetic	19269370
SWC5_YEAST	SWC5	genetic	20093466
SDC1_YEAST	SDC1	genetic	20093466
IF4A_YEAST	TIF2	genetic	20093466
LTHAD_YEAST	SRY1	genetic	20093466
YL050_YEAST	YLR050C	genetic	20093466
YM79_YEAST	YMR244W	genetic	20093466
SIN3_YEAST	SIN3	genetic	20093466
DGAT2_YEAST	DGA1	genetic	20093466
PDR10_YEAST	PDR10	genetic	20093466
MPM1_YEAST	MPM1	physical	20489023
TLG2_YEAST	TLG2	genetic	24586198
BUD31_YEAST	BUD31	genetic	27708008
YGY5_YEAST	YGL235W	genetic	27708008
RS6A_YEAST	RPS6B	genetic	27708008
RS6B_YEAST	RPS6B	genetic	27708008
MGR1_YEAST	MGR1	genetic	27708008
TPS2_YEAST	TPS2	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
RS17B_YEAST	RPS17B	genetic	27708008
SDC1_YEAST	SDC1	genetic	27708008
SA155_YEAST	SAP155	genetic	27708008
YGK1_YEAST	YGL101W	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
TBP7_YEAST	YTA7	genetic	27708008
HXT5_YEAST	HXT5	genetic	27708008
IF4A_YEAST	TIF2	genetic	27708008
DOHH_YEAST	LIA1	genetic	27708008
DHOM_YEAST	HOM6	genetic	27708008
BRE2_YEAST	BRE2	genetic	27708008
YM35_YEAST	YMR160W	genetic	27708008
USV1_YEAST	USV1	genetic	27453043
PPA5_YEAST	PHO5	genetic	27453043
LYP1_YEAST	LYP1	genetic	27453043
KCC4_YEAST	KCC4	genetic	27453043

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TEP1_YEAST

Related Literatures of Post-Translational Modification