dbPTM

KCC4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCC4_YEAST
UniProt AC	P25389
Protein Name	Probable serine/threonine-protein kinase KCC4
Gene Name	KCC4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1037
Subcellular Localization	Bud neck .
Protein Description	Involved in regulation of bud growth during cell cycle and in septin organization. Plays a role in cell wall synthesis..
Protein Sequence	MTVANTETHSAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSASIDDSILQNLVVLWHGRHADDIVSKLKENGTNKEKILYALLYRFKLDSVRGSNKKNRNKIKKTKKNKRSSTLSSSSSLLLNNRSIQSTPRRRTSKRHSREFSSSRKRSSFLLSSNPTDSSPIPLRSSKRITHINVASANTQATPSGVPNPHKRNSKKRSSKRLSYMPNTKRSSLTSKSLSNFTNLIDDDDWEYIEKDAKRTSSNFATLIDEIFEPEKFELAKREKAELQRKVQEAKRQSVNAQKINEDEFGSEVSDGMKELKKINDKVSSPLINYEFSQQELLQDIDTLLTNRYQLSSYTRPISRLDPGLTPVTETLPNNLKEKTALLQDTEKKIIETIRRSKFLGSLLNVRGGLSPGKSELAPIEESPIVSTTPLIYNDRMEPRRISDVEVPHFTRKSKHFTTANNRRSVLSLYAKDSIKDLNEFLIKEDPDLPPQGSTDNESRSEDPEIAESITDSRNIQYDEDDSKDGDNVNNDNILSDFPQGVGISQEYDMKDKNPNQSPISKSAEPTLVVKLPSLSSFQGKNASGLGLYQREPSKVTLPSLTSNNSSVGENIEDGAEKGTESEKIAASLSDDDLKEDNDKKDNDTVNAPTTVKKPPNSVLLKKFSKGKILELEIHAKIPEKRLYEGLHKLLEGWKQYGLKNLVFNITNMIITGKLVNDSILFLRSTLFEIMVLPNGDGRSLIKFNKKTGSTKTLTKLATEIQIILQKEGVLDK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVANTETH ------CCCCCCCCC	39.36	28889911
6	Phosphorylation	--MTVANTETHSAAK --CCCCCCCCCCCCC	32.30	30377154
8	Phosphorylation	MTVANTETHSAAKPS CCCCCCCCCCCCCCC	21.06	27017623
10	Phosphorylation	VANTETHSAAKPSST CCCCCCCCCCCCCCC	37.02	30377154
15	Phosphorylation	THSAAKPSSTIGPWK CCCCCCCCCCCCCCC	39.13	30377154
286	Acetylation	ILSHPLLKKYQTIKD HHCCHHHHHHCCCCC	58.06	24489116
296	Phosphorylation	QTIKDSKSIKDLPRE CCCCCCCCHHCCCCC	38.53	23749301
298	Acetylation	IKDSKSIKDLPRENT CCCCCCHHCCCCCCC	61.37	24489116
367	Phosphorylation	LYRFKLDSVRGSNKK HHHHHHHHHCCCCHH	24.93	28889911
388	Phosphorylation	KTKKNKRSSTLSSSS CCCCCCCCCCCCCCH	29.32	23749301
389	Phosphorylation	TKKNKRSSTLSSSSS CCCCCCCCCCCCCHH	37.08	23749301
390	Phosphorylation	KKNKRSSTLSSSSSL CCCCCCCCCCCCHHH	31.72	23749301
392	Phosphorylation	NKRSSTLSSSSSLLL CCCCCCCCCCHHHHH	28.41	23749301
393	Phosphorylation	KRSSTLSSSSSLLLN CCCCCCCCCHHHHHC	37.03	28889911
394	Phosphorylation	RSSTLSSSSSLLLNN CCCCCCCCHHHHHCC	22.14	28889911
395	Phosphorylation	SSTLSSSSSLLLNNR CCCCCCCHHHHHCCC	27.27	28152593
396	Phosphorylation	STLSSSSSLLLNNRS CCCCCCHHHHHCCCC	25.61	25752575
403	Phosphorylation	SLLLNNRSIQSTPRR HHHHCCCCCCCCCCC	27.40	28889911
407	Phosphorylation	NNRSIQSTPRRRTSK CCCCCCCCCCCCCCC	12.39	28889911
427	Phosphorylation	FSSSRKRSSFLLSSN CCCCCCCCCEECCCC	28.60	24961812
428	Phosphorylation	SSSRKRSSFLLSSNP CCCCCCCCEECCCCC	24.77	21440633
432	Phosphorylation	KRSSFLLSSNPTDSS CCCCEECCCCCCCCC	30.16	24961812
433	Phosphorylation	RSSFLLSSNPTDSSP CCCEECCCCCCCCCC	46.96	24961812
436	Phosphorylation	FLLSSNPTDSSPIPL EECCCCCCCCCCCCC	53.41	19823750
438	Phosphorylation	LSSNPTDSSPIPLRS CCCCCCCCCCCCCCC	40.26	28152593
439	Phosphorylation	SSNPTDSSPIPLRSS CCCCCCCCCCCCCCC	29.65	19823750
445	Phosphorylation	SSPIPLRSSKRITHI CCCCCCCCCCCEEEE	48.14	24961812
446	Phosphorylation	SPIPLRSSKRITHIN CCCCCCCCCCEEEEE	21.37	19823750
459	Phosphorylation	INVASANTQATPSGV EEEEECCCCCCCCCC	21.21	24961812
462	Phosphorylation	ASANTQATPSGVPNP EECCCCCCCCCCCCC	14.26	24961812
464	Phosphorylation	ANTQATPSGVPNPHK CCCCCCCCCCCCCCC	48.33	24961812
483	Phosphorylation	KRSSKRLSYMPNTKR CCCCCCHHCCCCCCC	24.34	21440633
484	Phosphorylation	RSSKRLSYMPNTKRS CCCCCHHCCCCCCCH	22.60	21440633
492	Phosphorylation	MPNTKRSSLTSKSLS CCCCCCHHCCCCCHH	39.43	28889911
497	Phosphorylation	RSSLTSKSLSNFTNL CHHCCCCCHHCCCCC	36.48	21440633
499	Phosphorylation	SLTSKSLSNFTNLID HCCCCCHHCCCCCCC	36.67	28889911
502	Phosphorylation	SKSLSNFTNLIDDDD CCCHHCCCCCCCCCC	33.11	26447709
518	Acetylation	EYIEKDAKRTSSNFA HHHHHHHHHCCCCHH	67.36	25381059
558	Phosphorylation	VQEAKRQSVNAQKIN HHHHHHHHCCCCCCC	22.75	28889911
571	Phosphorylation	INEDEFGSEVSDGMK CCHHHHCHHCCHHHH	39.90	28152593
574	Phosphorylation	DEFGSEVSDGMKELK HHHCHHCCHHHHHHH	25.13	28152593
597	Phosphorylation	PLINYEFSQQELLQD CCCCCCCCHHHHHHH	21.00	28889911
666	Phosphorylation	RRSKFLGSLLNVRGG HHHHHHHHHHHCCCC	31.65	22890988
675	Phosphorylation	LNVRGGLSPGKSELA HHCCCCCCCCCCCCC	34.58	21551504
679	Phosphorylation	GGLSPGKSELAPIEE CCCCCCCCCCCCCCC	43.70	25752575
687	Phosphorylation	ELAPIEESPIVSTTP CCCCCCCCCCCCCCC	13.72	25752575
691	Phosphorylation	IEESPIVSTTPLIYN CCCCCCCCCCCCEEC	27.55	27017623
692	Phosphorylation	EESPIVSTTPLIYND CCCCCCCCCCCEECC	22.87	23749301
693	Phosphorylation	ESPIVSTTPLIYNDR CCCCCCCCCCEECCC	14.48	27017623
697	Phosphorylation	VSTTPLIYNDRMEPR CCCCCCEECCCCCCC	20.77	19779198
707	Phosphorylation	RMEPRRISDVEVPHF CCCCCCCCCCCCCCC	33.52	28889911
722	Phosphorylation	TRKSKHFTTANNRRS CCCCCCCCCCCCHHH	25.39	19823750
723	Phosphorylation	RKSKHFTTANNRRSV CCCCCCCCCCCHHHH	26.83	24961812
729	Phosphorylation	TTANNRRSVLSLYAK CCCCCHHHHHHHEEH	24.95	28889911
732	Phosphorylation	NNRRSVLSLYAKDSI CCHHHHHHHEEHHHH	19.72	19823750
734	Phosphorylation	RRSVLSLYAKDSIKD HHHHHHHEEHHHHHH	14.29	19823750
736	Ubiquitination	SVLSLYAKDSIKDLN HHHHHEEHHHHHHHH	38.15	15699485
738	Phosphorylation	LSLYAKDSIKDLNEF HHHEEHHHHHHHHHH	30.72	28889911
740	Ubiquitination	LYAKDSIKDLNEFLI HEEHHHHHHHHHHHC	61.18	15699485
748	Ubiquitination	DLNEFLIKEDPDLPP HHHHHHCCCCCCCCC	59.20	15699485
758	Phosphorylation	PDLPPQGSTDNESRS CCCCCCCCCCCCCCC	27.60	20377248
763	Phosphorylation	QGSTDNESRSEDPEI CCCCCCCCCCCCHHH	47.57	28889911
765	Phosphorylation	STDNESRSEDPEIAE CCCCCCCCCCHHHHH	56.48	28889911
773	Phosphorylation	EDPEIAESITDSRNI CCHHHHHHHHHCCCC	23.05	22890988
775	Phosphorylation	PEIAESITDSRNIQY HHHHHHHHHCCCCCC	36.88	22890988
777	Phosphorylation	IAESITDSRNIQYDE HHHHHHHCCCCCCCC	20.69	22890988
782	Phosphorylation	TDSRNIQYDEDDSKD HHCCCCCCCCCCCCC	19.94	19779198
787	Phosphorylation	IQYDEDDSKDGDNVN CCCCCCCCCCCCCCC	44.99	28889911
800	Phosphorylation	VNNDNILSDFPQGVG CCCCCHHHCCCCCCC	33.15	30377154
822	Phosphorylation	KDKNPNQSPISKSAE CCCCCCCCCCCCCCC	30.73	25521595
825	Phosphorylation	NPNQSPISKSAEPTL CCCCCCCCCCCCCEE	24.76	28152593
827	Phosphorylation	NQSPISKSAEPTLVV CCCCCCCCCCCEEEE	30.95	19823750
831	Phosphorylation	ISKSAEPTLVVKLPS CCCCCCCEEEEECCC	24.56	29734811
838	Phosphorylation	TLVVKLPSLSSFQGK EEEEECCCCCCCCCC	51.85	19823750
840	Phosphorylation	VVKLPSLSSFQGKNA EEECCCCCCCCCCCC	33.18	22890988
841	Phosphorylation	VKLPSLSSFQGKNAS EECCCCCCCCCCCCC	27.21	22369663
848	Phosphorylation	SFQGKNASGLGLYQR CCCCCCCCCCCCCCC	43.90	22369663
858	Phosphorylation	GLYQREPSKVTLPSL CCCCCCCCCCCCCCC	34.70	21551504
861	Phosphorylation	QREPSKVTLPSLTSN CCCCCCCCCCCCCCC	36.37	19795423
864	Phosphorylation	PSKVTLPSLTSNNSS CCCCCCCCCCCCCCC	47.60	21551504
866	Phosphorylation	KVTLPSLTSNNSSVG CCCCCCCCCCCCCCC	33.47	19795423
867	Phosphorylation	VTLPSLTSNNSSVGE CCCCCCCCCCCCCCC	39.03	20377248
870	Phosphorylation	PSLTSNNSSVGENIE CCCCCCCCCCCCCCC	30.56	25521595
871	Phosphorylation	SLTSNNSSVGENIED CCCCCCCCCCCCCCC	35.94	25521595
882	Ubiquitination	NIEDGAEKGTESEKI CCCCCHHHCCHHHHH	71.27	15699485
888	Ubiquitination	EKGTESEKIAASLSD HHCCHHHHHHHHCCH	47.10	15699485
892	Phosphorylation	ESEKIAASLSDDDLK HHHHHHHHCCHHHHC	21.27	22890988
894	Phosphorylation	EKIAASLSDDDLKED HHHHHHCCHHHHCCC	36.18	22369663
899	Ubiquitination	SLSDDDLKEDNDKKD HCCHHHHCCCCCCCC	70.75	15699485
904	Ubiquitination	DLKEDNDKKDNDTVN HHCCCCCCCCCCCCC	69.18	15699485
905	Ubiquitination	LKEDNDKKDNDTVNA HCCCCCCCCCCCCCC	65.71	15699485
909	Phosphorylation	NDKKDNDTVNAPTTV CCCCCCCCCCCCCCC	23.16	22369663
914	Phosphorylation	NDTVNAPTTVKKPPN CCCCCCCCCCCCCCC	41.64	22369663
915	Phosphorylation	DTVNAPTTVKKPPNS CCCCCCCCCCCCCCC	29.30	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KCC4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KCC4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCC4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAP1_YEAST	NAP1	physical	10688190
CDC11_YEAST	CDC11	physical	11165249
CDC10_YEAST	CDC10	physical	11165249
CDC12_YEAST	CDC12	physical	11165249
CDC3_YEAST	CDC3	physical	11165249
SWE1_YEAST	SWE1	physical	12773812
NAP1_YEAST	NAP1	physical	16554755
VHR2_YEAST	VHR2	physical	16319894
SYSC_YEAST	SES1	physical	16319894
YP013_YEAST	CMR3	physical	16319894
ASND1_YEAST	YML096W	physical	16319894
PHB2_YEAST	PHB2	physical	16319894
SYEC_YEAST	GUS1	physical	16319894
MTW1_YEAST	MTW1	physical	16319894
GIN4_YEAST	GIN4	genetic	12773812
TPS1_YEAST	TPS1	genetic	19269370
OCA1_YEAST	OCA1	genetic	19269370
INP52_YEAST	INP52	genetic	19269370
CDC10_YEAST	CDC10	physical	20489023
CDC11_YEAST	CDC11	physical	20489023
CDC12_YEAST	CDC12	physical	20489023
CDC14_YEAST	CDC14	physical	20489023
CDC3_YEAST	CDC3	physical	20489023
NAP1_YEAST	NAP1	physical	20489023
NOG1_YEAST	NOG1	physical	20489023
SHS1_YEAST	SHS1	physical	20489023
BNI5_YEAST	BNI5	physical	21118957
BUD6_YEAST	BUD6	physical	21118957
CDC3_YEAST	CDC3	physical	21118957
CDC11_YEAST	CDC11	physical	21118957
NBP2_YEAST	NBP2	physical	21118957
PHO85_YEAST	PHO85	physical	21118957
PP2C1_YEAST	PTC1	physical	21118957
ARP8_YEAST	ARP8	physical	21460040
BUD4_YEAST	BUD4	physical	21460040
CRZ1_YEAST	CRZ1	physical	21460040
DRE2_YEAST	DRE2	physical	21460040
SYFB_YEAST	FRS1	physical	21460040
GLRX1_YEAST	GRX1	physical	21460040
GLRX3_YEAST	GRX3	physical	21460040
MFT1_YEAST	MFT1	physical	21460040
NNF1_YEAST	NNF1	physical	21460040
NTA1_YEAST	NTA1	physical	21460040
KPR1_YEAST	PRS1	physical	21460040
RAD23_YEAST	RAD23	physical	21460040
RPAC2_YEAST	RPC19	physical	21460040
RLA4_YEAST	RPP2B	physical	21460040
RT106_YEAST	RTT106	physical	21460040
GPT1_YEAST	SCT1	physical	21460040
SEC2_YEAST	SEC2	physical	21460040
SIP5_YEAST	SIP5	physical	21460040
SPT8_YEAST	SPT8	physical	21460040
WWM1_YEAST	WWM1	physical	21460040
YG1D_YEAST	YGR021W	physical	21460040
DPH4_YEAST	JJJ3	physical	21460040
YKJ1_YEAST	YKL091C	physical	21460040
REI1_YEAST	REI1	genetic	21127252
NAP1_YEAST	NAP1	physical	18086883

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KCC4_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2; SER-396; SER-439;SER-675; SER-679; SER-729; SER-773; THR-775; SER-822; SER-825; SER-838AND SER-841, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675, AND MASSSPECTROMETRY.	17563356 [Abstract]
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-848, AND MASSSPECTROMETRY.	15665377 [Abstract]