dbPTM

OCA1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OCA1_YEAST
UniProt AC	P50946
Protein Name	Putative tyrosine-protein phosphatase OCA1
Gene Name	OCA1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	238
Subcellular Localization	Cytoplasm .
Protein Description	Putative tyrosine-protein phosphatase required for protection against superoxide stress. Involved in cell-cycle delay in response to linoleic acid hydroperoxide (LoaOOH)..
Protein Sequence	MTSKVGEYEDVPEDESRLTEENVSVPEEEVEDEDEEEDDDDDHIYINEETESGREKVLVSHAPQERIVPPLNFCPVERYLYRSGQPSPVNFPFLLNLKLKTIIWLSNEEPQDTLLEFCDTHRINLQFAAINPDAGEDDNPWDGLTEHSIINVLQTIVTQENYPLLVCCGMGRHRTGTVIGCLRRIMGWNLASVSEEYRRFTGSRGGRILVELLIEAFDTNLVKIDKNKAPSWLLTALE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTSKVGEYE ------CCCCCCCCC	36.94	22814378
8	Phosphorylation	MTSKVGEYEDVPEDE CCCCCCCCCCCCCCH	16.11	19823750
16	Phosphorylation	EDVPEDESRLTEENV CCCCCCHHHCCCCCC	44.93	19823750
19	Phosphorylation	PEDESRLTEENVSVP CCCHHHCCCCCCCCC	39.89	28132839
24	Phosphorylation	RLTEENVSVPEEEVE HCCCCCCCCCHHHCC	43.46	22369663
45	Phosphorylation	DDDDDHIYINEETES CCCCCCEEEECCCCC	8.35	19779198
50	Phosphorylation	HIYINEETESGREKV CEEEECCCCCCCEEE	29.31	19823750
52	Phosphorylation	YINEETESGREKVLV EEECCCCCCCEEEEE	51.04	19823750
87	Phosphorylation	LYRSGQPSPVNFPFL HHCCCCCCCCCCCHH	33.32	28152593

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OCA1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OCA1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OCA1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIW14_YEAST	SIW14	physical	11805837
SIW14_YEAST	SIW14	physical	16554755
OCA2_YEAST	OCA2	physical	16554755
ESF2_YEAST	ESF2	physical	16554755
RRS1_YEAST	RRS1	physical	16554755
SIW14_YEAST	SIW14	physical	11283351
SIW14_YEAST	SIW14	physical	18719252
PVH1_YEAST	YVH1	genetic	19269370
ATG17_YEAST	ATG17	genetic	19269370
FKH2_YEAST	FKH2	genetic	19269370
PPQ1_YEAST	PPQ1	genetic	19269370
KAPB_YEAST	TPK2	genetic	19269370
ISR1_YEAST	ISR1	genetic	19269370
OCA2_YEAST	OCA2	physical	20489023
SIW14_YEAST	SIW14	physical	20489023
OCA5_YEAST	OCA5	genetic	19176519
GCN2_YEAST	GCN2	genetic	19176519
SIW14_YEAST	SIW14	genetic	21409566
SRS2_YEAST	SRS2	genetic	21459050
CBF1_YEAST	CBF1	genetic	21127252
PP2C1_YEAST	PTC1	genetic	21127252
CTK1_YEAST	CTK1	genetic	21127252
IXR1_YEAST	IXR1	genetic	21127252
FKH2_YEAST	FKH2	genetic	21127252
SWI4_YEAST	SWI4	genetic	21127252
SSN8_YEAST	SSN8	genetic	21127252
CSM1_YEAST	CSM1	genetic	27708008
DHAS_YEAST	HOM2	genetic	27708008
YD179_YEAST	YDR179W-A	genetic	27708008
RLA4_YEAST	RPP2B	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
AIM26_YEAST	AIM26	genetic	27708008
UBR2_YEAST	UBR2	genetic	27708008
NYV1_YEAST	NYV1	genetic	27708008
NIP80_YEAST	NIP100	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OCA1_YEAST

Related Literatures of Post-Translational Modification