ESF2_YEAST - dbPTM
ESF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ESF2_YEAST
UniProt AC P53743
Protein Name Pre-rRNA-processing protein ESF2
Gene Name ESF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 316
Subcellular Localization Nucleus, nucleolus .
Protein Description Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2. Stimulates DBP8 RNA helicase ATPase activity..
Protein Sequence MSEKVNSDFEDFSSDEETDQHNVLIQTKKKISSKDDIFSKKVEDIESENESDIEEEQKQEEKEDVEQPDKENGEKLDREVEEQASSTTSLDLKTEKLRQLVKSKAAKKSKHKTGVVYFSSIPPYMKPAKMRQILTRFGEVDRLFLKKEDDQKYKQRVKGGGNKKNKYEEGWAEFIRKRDAKLCAETLNGNIIGGKKGTFYHDDILNVKYLPGFKWADLTEQIARENDIRQAKLEMEISQANKLNAEFIRNVEQSKMIQNIKNSRKRAGKEGESADSHPHREFKQRRVETSRANAPSDIKQQSSGSKDLGNVLTNLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEKVNSDF
------CCCCCCCCC		46.2319795423
7Phosphorylation-MSEKVNSDFEDFSS
-CCCCCCCCCCCCCC		46.8222369663
13PhosphorylationNSDFEDFSSDEETDQ
CCCCCCCCCCCCHHH		49.5622369663
14PhosphorylationSDFEDFSSDEETDQH
CCCCCCCCCCCHHHH		49.3822369663
18PhosphorylationDFSSDEETDQHNVLI
CCCCCCCHHHHCCHH		38.6222890988
27PhosphorylationQHNVLIQTKKKISSK
HHCCHHHHCCCCCCC		37.5322890988
32PhosphorylationIQTKKKISSKDDIFS
HHHCCCCCCCHHHHH		39.9730377154
33PhosphorylationQTKKKISSKDDIFSK
HHCCCCCCCHHHHHH		43.5127214570
34SuccinylationTKKKISSKDDIFSKK
HCCCCCCCHHHHHHH		53.2623954790
34AcetylationTKKKISSKDDIFSKK
HCCCCCCCHHHHHHH		53.2624489116
47PhosphorylationKKVEDIESENESDIE
HHHHHHHCCCHHHHH		46.1622369663
51PhosphorylationDIESENESDIEEEQK
HHHCCCHHHHHHHHH		56.3122369663
85PhosphorylationREVEEQASSTTSLDL
HHHHHHHCCCCCHHH		28.1022369663
86PhosphorylationEVEEQASSTTSLDLK
HHHHHHCCCCCHHHH		38.4322369663
87PhosphorylationVEEQASSTTSLDLKT
HHHHHCCCCCHHHHH		20.2222369663
88PhosphorylationEEQASSTTSLDLKTE
HHHHCCCCCHHHHHH		29.2822369663
89PhosphorylationEQASSTTSLDLKTEK
HHHCCCCCHHHHHHH		21.7022369663
166AcetylationGGGNKKNKYEEGWAE
CCCCCCCCHHHHHHH		64.0224489116
195AcetylationNGNIIGGKKGTFYHD
CCCCCCCCCCCCCCC		42.7025381059
214AcetylationVKYLPGFKWADLTEQ
CEECCCCCHHHHHHH		47.6024489116
255AcetylationIRNVEQSKMIQNIKN
HHHHHHHHHHHHHHH		39.4525381059
269AcetylationNSRKRAGKEGESADS
HHHHHCCCCCCCCCC		62.6525381059
296PhosphorylationTSRANAPSDIKQQSS
HHCCCCCHHHHHCCC		49.9423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ESF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ESF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ESF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RRP5_YEASTRRP5physical
15964808
UTP10_YEASTUTP10physical
15964808
UTP22_YEASTUTP22physical
15964808
PWP2_YEASTPWP2physical
15964808
UTP12_YEASTDIP2physical
15964808
DBP4_YEASTHCA4physical
15964808
ESF1_YEASTESF1physical
15964808
MPP10_YEASTMPP10physical
15964808
NOL10_YEASTENP2physical
15964808
UTP4_YEASTUTP4physical
15964808
HAS1_YEASTHAS1physical
15964808
ESF2_YEASTESF2physical
15964808
LCP5_YEASTLCP5physical
15964808
FBRL_YEASTNOP1physical
15964808
RS3_YEASTRPS3physical
15964808
RS2_YEASTRPS2physical
15964808
RL3_YEASTRPL3physical
15964808
RLP7_YEASTRLP7physical
15964808
RS7A_YEASTRPS7Aphysical
15964808
RL18A_YEASTRPL18Aphysical
15964808
RL18B_YEASTRPL18Aphysical
15964808
KRR1_YEASTKRR1physical
16554755
FBRL_YEASTNOP1physical
16554755
TSR1_YEASTTSR1physical
16554755
IF2G_YEASTGCD11physical
16554755
PRP43_YEASTPRP43physical
16554755
NOL10_YEASTENP2physical
16554755
RRP3_YEASTRRP3physical
16554755
RS24A_YEASTRPS24Bphysical
16554755
RS24B_YEASTRPS24Bphysical
16554755
UTP12_YEASTDIP2physical
16554755
NOP56_YEASTNOP56physical
16554755
UTP13_YEASTUTP13physical
16554755
UTP21_YEASTUTP21physical
16554755
DHR1_YEASTECM16physical
16554755
NAT10_YEASTKRE33physical
16554755
NOP58_YEASTNOP58physical
16554755
EIF3B_YEASTPRT1physical
16554755
BMS1_YEASTBMS1physical
16554755
HSP82_YEASTHSP82physical
16554755
SNF5_YEASTSNF5genetic
27708008
ERS1_YEASTERS1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
INM1_YEASTINM1genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
SEI1_YEASTFLD1genetic
27708008
CY1_YEASTCYT1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
STU1_YEASTSTU1genetic
27708008
FAD1_YEASTFAD1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
CDC20_YEASTCDC20genetic
27708008
GPI10_YEASTGPI10genetic
27708008
YHS2_YEASTCIA2genetic
27708008
STS1_YEASTSTS1genetic
27708008
ERG27_YEASTERG27genetic
27708008
SEC22_YEASTSEC22genetic
27708008
ORC1_YEASTORC1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
APC5_YEASTAPC5genetic
27708008
BUR1_YEASTSGV1genetic
27708008
MED10_YEASTNUT2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
HIR1_YEASTHIR1genetic
27708008
PP2C3_YEASTPTC3genetic
27708008
SCS22_YEASTSCS22genetic
27708008
YBU0_YEASTYBR090Cgenetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
MGR1_YEASTMGR1genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
ATG15_YEASTATG15genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
PEX5_YEASTPEX5genetic
27708008
PUF6_YEASTPUF6genetic
27708008
AIM11_YEASTAIM11genetic
27708008
RAD4_YEASTRAD4genetic
27708008
GLRX4_YEASTGRX4genetic
27708008
VAM7_YEASTVAM7genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
VMA21_YEASTVMA21genetic
27708008
TBP7_YEASTYTA7genetic
27708008
YOR1_YEASTYOR1genetic
27708008
YHA8_YEASTYHL008Cgenetic
27708008
GLPK_YEASTGUT1genetic
27708008
DSE2_YEASTDSE2genetic
27708008
SKN7_YEASTSKN7genetic
27708008
EPS1_YEASTEPS1genetic
27708008
DOT5_YEASTDOT5genetic
27708008
6P21_YEASTPFK26genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
BFA1_YEASTBFA1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
POM33_YEASTPOM33genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
TDA1_YEASTTDA1genetic
27708008
NOP12_YEASTNOP12genetic
27708008
HAP5_YEASTHAP5genetic
27708008
BRR1_YEASTBRR1genetic
27708008
ICS2_YEASTICS2genetic
27708008
APA1_YEASTAPA1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
VPS41_YEASTVPS41genetic
27708008
ARX1_YEASTARX1genetic
27708008
NBP2_YEASTNBP2genetic
27708008
YD179_YEASTYDR179W-Agenetic
27708008
UME6_YEASTUME6genetic
27708008
MNN10_YEASTMNN10genetic
27708008
YGI1_YEASTYGL081Wgenetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
ADH4_YEASTADH4genetic
27708008
RME1_YEASTRME1genetic
27708008
ASK10_YEASTASK10genetic
27708008
MVB12_YEASTMVB12genetic
27708008
OPI1_YEASTOPI1genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
HTD2_YEASTHTD2genetic
27708008
KC11_YEASTYCK1genetic
27708008
SNL1_YEASTSNL1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
ATG32_YEASTATG32genetic
27708008
THIK_YEASTPOT1genetic
27708008
UBL1_YEASTYUH1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
MRT4_YEASTMRT4genetic
27708008
TCD2_YEASTTCD2genetic
27708008
MCR1_YEASTMCR1genetic
27708008
NNK1_YEASTNNK1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ENT2_YEASTENT2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
YL278_YEASTYLR278Cgenetic
27708008
ATP18_YEASTATP18genetic
27708008
STB4_YEASTSTB4genetic
27708008
LDS2_YEASTLDS2genetic
27708008
HAL9_YEASTHAL9genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
PMT3_YEASTPMT3genetic
27708008
HAT1_YEASTHAT1genetic
27708008
CHL1_YEASTCHL1genetic
27708008
EF1G1_YEASTCAM1genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
FMP40_YEASTFMP40genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
NAA30_YEASTMAK3genetic
27708008
SUE1_YEASTSUE1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ESF2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33; SER-47; SER-51 ANDTHR-88, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47 AND SER-51, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-13 AND SER-14,AND MASS SPECTROMETRY.

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