PMT3_YEAST - dbPTM
PMT3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PMT3_YEAST
UniProt AC P47190
Protein Name Dolichyl-phosphate-mannose--protein mannosyltransferase 3 {ECO:0000305}
Gene Name PMT3 {ECO:0000303|PubMed:8585318}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 753
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT5 and more rarely with PMT1 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Seems to have redundant activity to PMT2..
Protein Sequence MPYRVATGYSEKSTDDDLIWRTPIVKEELEDADNFLKDDAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYKIGRNNHVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPSGEVYPDYIDYVKMRLFQAMFSSLCVPLAYFTGRAIGFSRLSVWLFTILVIFENSYATLGKFILLDSMLLFFTVSSYFCLAKFHTMRKSPFSARWWLWLCLTGLNLGCAISVKMVGLFIISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLIIIPVCVFLLCFKIHFDLLSNSGPGDSTMPSLFQASLNGTKVGKGPRDVALGSSIISIKNQALGGALLHSHVQPFPEGSEQQQVTVYGYSDANNEWFFQRIRGVEPWTDAENKTIEFVKGGEMYRLMHRLTGKNLHTHEVPAPISKSEYEVSAYGDVDLGDYKDNWIIEIVEQVGEEDPTLLHPLSTSFRIKNSILGCYLAQSGKHLPEWGFRQGEVVCLKHASKRDKRTWWNIETHENERLPQGEDFVYPKTSFFRNFMQLNSAMMATNNALVPNPEKFDGIASSAWQWPTLNVGVRLCEWSEKSIKYFLLGSPASVWPSSIAVCALIIHVIFLTLKWQRQCVILSDPVERDVFVMAAFYPLLAWLLHYMPFVVMSRVVYAHHYLPTLYFALMILSYYFDMITKRWATRNTGKFLRLGAYIVYGSIVIAGFFYFSPFSFGMDGPVDDYAYLAWLPTWQIVEDIRNT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12UbiquitinationVATGYSEKSTDDDLI
ECCCCCCCCCCCCCC		53.3623749301
13PhosphorylationATGYSEKSTDDDLIW
CCCCCCCCCCCCCCC		32.7721440633
22PhosphorylationDDDLIWRTPIVKEEL
CCCCCCCCHHHHHHH		11.4521440633
123PhosphorylationLSGYLAGYNGSWDFP
HHHHHCCCCCCCCCC		15.6727017623
124N-linked_GlycosylationSGYLAGYNGSWDFPS
HHHHCCCCCCCCCCC		36.78-
126PhosphorylationYLAGYNGSWDFPSGE
HHCCCCCCCCCCCCC		21.6027017623
131PhosphorylationNGSWDFPSGEVYPDY
CCCCCCCCCCCCCCH		47.8027017623
135PhosphorylationDFPSGEVYPDYIDYV
CCCCCCCCCCHHHHH		6.0127017623
138PhosphorylationSGEVYPDYIDYVKMR
CCCCCCCHHHHHHHH		7.3827017623
141PhosphorylationVYPDYIDYVKMRLFQ
CCCCHHHHHHHHHHH		7.7527017623
172PhosphorylationAIGFSRLSVWLFTIL
HHCHHHHHHHHHHHH		15.3328889911
313PhosphorylationSNSGPGDSTMPSLFQ
CCCCCCCCCCCHHHH		32.3027017623
314PhosphorylationNSGPGDSTMPSLFQA
CCCCCCCCCCHHHHH		37.5327017623
322PhosphorylationMPSLFQASLNGTKVG
CCHHHHHHHCCCCCC		16.1627017623
324N-linked_GlycosylationSLFQASLNGTKVGKG
HHHHHHHCCCCCCCC		54.30-
398N-linked_GlycosylationEPWTDAENKTIEFVK
CCCCCCCCCEEEEEE		48.79-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PMT3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PMT3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PMT3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PMT5_YEASTPMT5physical
12551906
PMT2_YEASTPMT2genetic
8918452
PMT1_YEASTPMT1genetic
8918452
PMT2_YEASTPMT2genetic
16269340
HUA2_YEASTHUA2genetic
16269340
YPK9_YEASTYPK9genetic
16269340
RDL1_YEASTRDL1genetic
16269340
MPD1_YEASTMPD1genetic
16269340
GET2_YEASTGET2genetic
16269340
GST1_YEASTGTT1physical
18719252
PMT2_YEASTPMT2genetic
18408719
PMT2_YEASTPMT2genetic
20093466
SNF6_YEASTSNF6genetic
20093466
CANB_YEASTCNB1genetic
20093466
ICT1_YEASTICT1genetic
20093466
SAM37_YEASTSAM37genetic
20093466
ATG16_YEASTATG16genetic
20093466
MEP1_YEASTMEP1physical
16093310
VMA21_YEASTVMA21genetic
27708008
PMT2_YEASTPMT2genetic
27708008
CANB_YEASTCNB1genetic
27708008
ATG16_YEASTATG16genetic
27708008
CR3L1_HUMANCREB3L1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PMT3_YEAST

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Related Literatures of Post-Translational Modification

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