ATG16_YEAST - dbPTM
ATG16_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATG16_YEAST
UniProt AC Q03818
Protein Name Autophagy protein 16
Gene Name ATG16
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 150
Subcellular Localization Preautophagosomal structure membrane
Peripheral membrane protein .
Protein Description Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress..
Protein Sequence MGNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAIGGNIVSHDDALLNTLAILQKELKSKEQEIRRLKEVIALKNKNTERLNDELISGTIENNVLQQKLSDLKKEHSQLVARWLKKTEKETEAMNSEIDGTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
105PhosphorylationRLNDELISGTIENNV
HCCHHHHHHHHHHHH
42.3727017623
144PhosphorylationKETEAMNSEIDGTK-
HHHHHHHHCCCCCC-
23.8928889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATG16_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATG16_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATG16_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG12_YEASTATG12physical
11283351
ATG12_YEASTATG12physical
10406794
ATG5_YEASTATG5physical
10406794
ATG16_YEASTATG16physical
10406794
ATG12_YEASTATG12physical
11897782
ATG16_YEASTATG16physical
11283351
ATG5_YEASTATG5physical
11283351
ATG16_YEASTATG16physical
18719252
ATG16_YEASTATG16physical
19889643
UBP14_YEASTUBP14genetic
20093466
STE50_YEASTSTE50genetic
20093466
SAC3_YEASTSAC3genetic
20093466
HMO1_YEASTHMO1genetic
20093466
XRN1_YEASTXRN1genetic
20093466
AROC_YEASTARO2genetic
20093466
MUP1_YEASTMUP1genetic
20093466
PEX18_YEASTPEX18genetic
20093466
THIK_YEASTPOT1genetic
20093466
SAC1_YEASTSAC1genetic
20093466
PHO23_YEASTPHO23genetic
20093466
ATG3_YEASTATG3genetic
20093466
DPP3_YEASTYOL057Wgenetic
20093466
PMT3_YEASTPMT3genetic
20093466
TBP6_YEASTYTA6genetic
20093466
PUR1_YEASTADE4genetic
20421943
MDJ1_YEASTMDJ1genetic
21987634
GEP5_YEASTGEP5genetic
21987634
UBX4_YEASTUBX4genetic
21987634
ATG17_YEASTATG17genetic
24586198
ATG18_YEASTATG18genetic
24586198
ATG21_YEASTATG21genetic
24586198
ATG9_YEASTATG9genetic
24586198
TEP1_YEASTTEP1genetic
24586198
BECN1_YEASTVPS30genetic
24586198
GPR1_YEASTGPR1genetic
27708008
ARO1_YEASTARO1genetic
27708008
SAC3_YEASTSAC3genetic
27708008
RV167_YEASTRVS167genetic
27708008
AROC_YEASTARO2genetic
27708008
MUP1_YEASTMUP1genetic
27708008
DBF2_YEASTDBF2genetic
27708008
THIK_YEASTPOT1genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
IDH1_YEASTIDH1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
ATG3_YEASTATG3genetic
27708008
DPP3_YEASTYOL057Wgenetic
27708008
IDH2_YEASTIDH2genetic
27708008
TBP6_YEASTYTA6genetic
27708008
CHMU_YEASTARO7genetic
27708008
ATG5_YEASTATG5physical
25691244
ATG21_YEASTATG21physical
25691244

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATG16_YEAST

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Related Literatures of Post-Translational Modification

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