ATG21_YEAST - dbPTM
ATG21_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATG21_YEAST
UniProt AC Q02887
Protein Name Autophagy-related protein 21
Gene Name ATG21
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 496
Subcellular Localization Cytoplasm. Vacuole. And perivacuolar punctate structures.
Protein Description Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage. Essential for maturation of proaminopeptidase I..
Protein Sequence MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKKTSNNNGSASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEMLFSTSLIAIADRGQGLNKGKKLKIVNTKRKCTICEIVFPHEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLANATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNGHWNEEEYILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNESNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63PhosphorylationESRNNEESILITNGS
CCCCCCCCEEEECCC		19.2722369663
67PhosphorylationNEESILITNGSRDRT
CCCCEEEECCCCCCC		30.0422369663
70PhosphorylationSILITNGSRDRTDAE
CEEEECCCCCCCCCC		32.8330377154
187PhosphorylationWEDHYKRSQANSFSN
HHHHHHHHHHHCCCC		29.5022369663
191PhosphorylationYKRSQANSFSNASNT
HHHHHHHCCCCCCCC		32.8222369663
193PhosphorylationRSQANSFSNASNTGT
HHHHHCCCCCCCCCC		31.1622369663
196PhosphorylationANSFSNASNTGTLEG
HHCCCCCCCCCCCCC		38.8923749301
198PhosphorylationSFSNASNTGTLEGDS
CCCCCCCCCCCCCCH		29.1122369663
205PhosphorylationTGTLEGDSANLNRVA
CCCCCCCHHHHHHHH		29.8828889911
213PhosphorylationANLNRVATNLLANAT
HHHHHHHHHHHHHHH		24.4421440633
222UbiquitinationLLANATQKSVNGSNP
HHHHHHHHHHCCCCC		52.6023749301
223PhosphorylationLANATQKSVNGSNPS
HHHHHHHHHCCCCCC		15.8222369663
230PhosphorylationSVNGSNPSVRTRRNS
HHCCCCCCHHHHHHH		28.6023749301
233PhosphorylationGSNPSVRTRRNSLRS
CCCCCHHHHHHHHHH		31.6517563356
237PhosphorylationSVRTRRNSLRSKIRP
CHHHHHHHHHHHCCC		24.2917287358
317AcetylationLLATASDKGTIIRVF
EEEEECCCCCEEEEE		56.3024489116
381PhosphorylationLFKLDDASNSLPGDN
EEEECCCCCCCCCCC		33.6721440633
403PhosphorylationEEEYILASNSNPSMG
HHHEEEECCCCCCCC		37.0324961812
405PhosphorylationEYILASNSNPSMGTP
HEEEECCCCCCCCCC		47.8524961812
408PhosphorylationLASNSNPSMGTPKEI
EECCCCCCCCCCCCC		33.8124961812
411PhosphorylationNSNPSMGTPKEIPLS
CCCCCCCCCCCCCCC		23.6524961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATG21_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATG21_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATG21_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TVP15_YEASTTVP15physical
18719252
LSB6_YEASTLSB6physical
18719252
SLT2_YEASTSLT2genetic
19547744
WHI2_YEASTWHI2genetic
19547744
GEM1_YEASTGEM1genetic
20093466
RIM1_YEASTRIM1genetic
20093466
QRI7_YEASTQRI7genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
SSD1_YEASTSSD1genetic
20093466
BCS1_YEASTBCS1genetic
20093466
UBP3_YEASTUBP3genetic
20093466
IES1_YEASTIES1genetic
20093466
XRN1_YEASTXRN1genetic
20093466
AROC_YEASTARO2genetic
20093466
AAKG_YEASTSNF4genetic
20093466
MUP1_YEASTMUP1genetic
20093466
LST4_YEASTLST4genetic
20093466
VPS13_YEASTVPS13genetic
20093466
RSC2_YEASTRSC2genetic
20093466
ATP18_YEASTATP18genetic
20093466
RCO1_YEASTRCO1genetic
20093466
GBLP_YEASTASC1genetic
20093466
BRE5_YEASTBRE5genetic
20093466
MSN1_YEASTMSN1genetic
20093466
VPS5_YEASTVPS5genetic
20093466
INP53_YEASTINP53genetic
20093466
RV161_YEASTRVS161genetic
20526336
FIMB_YEASTSAC6genetic
20526336
RIC1_YEASTRIC1genetic
20526336
TAT1_YEASTTAT1genetic
20526336
CCZ1_YEASTCCZ1genetic
20526336
MKS1_YEASTMKS1genetic
20526336
YPT35_YEASTYPT35genetic
20526336
SWA2_YEASTSWA2genetic
20526336
RAD1_YEASTRAD1genetic
20526336
TGS1_YEASTTGS1genetic
20526336
SST2_YEASTSST2genetic
20526336
TRE1_YEASTTRE1genetic
20526336
NPC1_YEASTNCR1genetic
20526336
CCZ1_YEASTCCZ1genetic
21987634
PP2C1_YEASTPTC1genetic
21987634
RGP1_YEASTRGP1genetic
21987634
DOP1_YEASTDOP1genetic
21987634
MS116_YEASTMSS116genetic
21987634
SSD1_YEASTSSD1genetic
21987634
SWA2_YEASTSWA2genetic
21987634
RV167_YEASTRVS167genetic
21987634
SNF1_YEASTSNF1genetic
21987634
CIN8_YEASTCIN8genetic
21987634
UBP3_YEASTUBP3genetic
21987634
MDJ1_YEASTMDJ1genetic
21987634
PMA1_YEASTPMA1genetic
21987634
AAKG_YEASTSNF4genetic
21987634
XRN1_YEASTXRN1genetic
21987634
CBS_YEASTCYS4genetic
21987634
SLT2_YEASTSLT2genetic
21987634
YPT35_YEASTYPT35genetic
21987634
PLMT_YEASTOPI3genetic
21987634
VPS13_YEASTVPS13genetic
21987634
RIC1_YEASTRIC1genetic
21987634
YPT6_YEASTYPT6genetic
21987634
BRE5_YEASTBRE5genetic
21987634
CARP_YEASTPEP4genetic
21987634
KIP2_YEASTKIP2genetic
21987634
TGS1_YEASTTGS1genetic
21987634
AIM44_YEASTAIM44genetic
21987634
ATG29_YEASTATG29genetic
24586198
ATG4_YEASTATG4genetic
24586198
ATG7_YEASTATG7genetic
24586198
CCZ1_YEASTCCZ1genetic
24586198
SNX4_YEASTSNX4genetic
24586198
TEP1_YEASTTEP1genetic
24586198
TLG2_YEASTTLG2genetic
24586198
BECN1_YEASTVPS30genetic
24586198
VPS21_YEASTVPS21genetic
27708008
GEM1_YEASTGEM1genetic
27708008
AGP2_YEASTAGP2genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
QRI7_YEASTQRI7genetic
27708008
TPS2_YEASTTPS2genetic
27708008
BCS1_YEASTBCS1genetic
27708008
IES1_YEASTIES1genetic
27708008
SA155_YEASTSAP155genetic
27708008
AAKG_YEASTSNF4genetic
27708008
AROC_YEASTARO2genetic
27708008
MUP1_YEASTMUP1genetic
27708008
SLT2_YEASTSLT2genetic
27708008
BCK1_YEASTBCK1genetic
27708008
F26_YEASTFBP26genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
LST4_YEASTLST4genetic
27708008
VPS13_YEASTVPS13genetic
27708008
LDB18_YEASTLDB18genetic
27708008
ATP18_YEASTATP18genetic
27708008
GBLP_YEASTASC1genetic
27708008
IDH1_YEASTIDH1genetic
27708008
VPS5_YEASTVPS5genetic
27708008
INP53_YEASTINP53genetic
27708008
VPS17_YEASTVPS17genetic
27708008
FUMH_YEASTFUM1genetic
27708008
ATG8_YEASTATG8physical
25691244
ATG16_YEASTATG16physical
25691244
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATG21_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-191 AND THR-233,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223 AND THR-233, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY.

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