DOP1_YEAST - dbPTM
DOP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOP1_YEAST
UniProt AC Q03921
Protein Name Protein dopey
Gene Name DOP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1698
Subcellular Localization Golgi apparatus membrane
Peripheral membrane protein . Late Golgi.
Protein Description Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum..
Protein Sequence MSLPLKPLTIDSNNKQLDSKQKKFRANVERALERFDSVTEWADYIASLGTLLKALQSWSPKFQNVRYYVPSPYQVSRRLTSSLSPALPAGVHQKTLEVYTYIFEHIGLETLATECNIWIPGILPLMTYASMSVRSHLIELYDNYILLLPQTTLRLLIRPLISSLLPGIDDESNDFLPLTLKLIETLQENLDDDSLFWQTLFLVMTANKGRRLGGLTWLTRKFPSLNAVPHLVNKIKMEAEENPSETETNDSHLDRKKRKEEAFKVLLPAAKDLVTPEPGLLIRCLVGCLEDENDILIKRSVLDLLLQRLRLDSPVLNVLITSEDKKLLIMSCCRTTLSKDMSLNRRIWNWLLGPTAGGMLNNNGGNSMEYTTSVKSANEESNVYFTKYGLSALLEGLSDLLSEEESVLTAFRISMAVMDRWEIGSLVIPELFIPLLYSSEKFKQNEQIMKTARTFFDNTETNIIWGKLFQELEDIKNLKILDFVLTNFNIGNDEEIIVRHLPLILLTLLALPSNDKDFDNIYKLQKFSLYNKLLNYIPERALLPLSHSKLKHDDEVSCEELLAKIRGFYTNVSNPSSILEKENIAERLPPFTTEDLTFLIADLIQKKLLSSLWDLENINESSKLFIAIFEKIPESEELKGRSHISWSDKKITQSIFEAIPRLCESNNDAKSEEIVGIVEIFGNYLYSRMEFIESMKLLKVVMMAVWKSLKDPRHQILGVKNLKTLNRFIPSKFIESALVYTFVEEEDISERLSVLDLLWTQLDSDSNLIRRPLELILGELFDDQNPFYLTVSKWILSILNSGSASRLFYILTDNILKVNRLEKERLDERDDLDMLTYEFQMLAYVLKTNNGRTRKVFSTELTSIKSSTIWKNEDVSTYKSLLLVTLMRFLNIKSNTHAKSIRSALILLDILLDGTEQNFKDIVIFLLQMSSKYIAEEGIEPELIAVSLLDIVSKVLRLSHDNGIKLDIFDDNAAHLKYIDFLVTSVSNMKSPLIVTAYVKLLSESIVYFENSIFRMILPLSASLVQCVQRLFLLEKREGGYYQPIALLLGGLEELLEISHGYLVTEEREGYFSGSNLKGDFIQSVVSNVFSSDSSNEESKIQGERDVILQSFRQVISCCLDIWYWAHNISCKSNDDSSLDATNHNSYKFKFRSKKLLETLFLLEPLELLENLISIRSDNTTVTLVHVLDGNKPAITIPHLLYGVIIRYNRTASVKFSNRDGSRSSTTKLTKGEPSMLKRLSGESIIAFLFNYVDSVENSAMEEFYGDFLLFFREVATNYNLYSDVSLSILKLVALISGKVSKTQFGEQKRVRREISDVFFKYLPNAFINFTNLYRGHPDSFKDLEFVVWRVQYIVNDQIGGDKFNTTLATIVNQCLTPYIKPKSEKTIPGYVLELAAVVSHLGSKVKSWRLLIAELFQNDKKLSVIGSDQTWEKIIYEWSIYPENKSKILNDLLLEIGSKRSSVTPTLITFNLGSDSEVEYKCQNLLKISYLLMVSPNDAYLLHFSSLISCIFHYLVSKDIKLKGSCWILLRVLLLRFSESHFNDYWSMISYCLQTNLQEFYESLQIQSEVDPQTILQVCKTLDLLLLLNMEGFTSTNEWIFVIDTINCVYKTNSFVALVDEIAEFKDYEITKTDDLELPTTLKDGLPLLRGIHKIERHTQLRSFFQNLSYLHYEKVYGLGSVDLYGCGEDLKKDILS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationSNNKQLDSKQKKFRA
CCCCCCCHHHHHHHH		45.6521440633
61AcetylationALQSWSPKFQNVRYY
HHHHCCCCCCCEEEE		54.8124489116
244PhosphorylationMEAEENPSETETNDS
HHCCCCCCCCCCCHH		69.5922369663
246PhosphorylationAEENPSETETNDSHL
CCCCCCCCCCCHHHH		53.0722369663
248PhosphorylationENPSETETNDSHLDR
CCCCCCCCCHHHHCH		52.3125521595
251PhosphorylationSETETNDSHLDRKKR
CCCCCCHHHHCHHHH		28.1922369663
581UbiquitinationNPSSILEKENIAERL
CHHHHHHHCCHHHHC		53.2523749301
639UbiquitinationIPESEELKGRSHISW
CCCCHHHCCCCCCCC		56.4023749301
760PhosphorylationSVLDLLWTQLDSDSN
HHHHHHHHHCCCCCC		21.1530377154
836PhosphorylationRDDLDMLTYEFQMLA
CCCHHHHHHHHHHHH		17.8628889911
837PhosphorylationDDLDMLTYEFQMLAY
CCHHHHHHHHHHHHH		15.7028889911
844PhosphorylationYEFQMLAYVLKTNNG
HHHHHHHHHHHHCCC		11.4528889911
877PhosphorylationWKNEDVSTYKSLLLV
CCCCCHHHHHHHHHH		34.5127017623
878PhosphorylationKNEDVSTYKSLLLVT
CCCCHHHHHHHHHHH		7.3527017623
885PhosphorylationYKSLLLVTLMRFLNI
HHHHHHHHHHHHHCC		18.1427017623
931PhosphorylationIFLLQMSSKYIAEEG
HHHHHHCCHHHHHCC		24.9227017623
953PhosphorylationVSLLDIVSKVLRLSH
HHHHHHHHHHHHHHC		19.8528889911
984PhosphorylationKYIDFLVTSVSNMKS
HHHHEHHHCCCCCCC		26.0919779198
985PhosphorylationYIDFLVTSVSNMKSP
HHHEHHHCCCCCCCC		18.9719823750
987PhosphorylationDFLVTSVSNMKSPLI
HEHHHCCCCCCCCEE		30.8619823750
996PhosphorylationMKSPLIVTAYVKLLS
CCCCEEHHHHHHHHH		12.7919779198
998PhosphorylationSPLIVTAYVKLLSES
CCEEHHHHHHHHHCH		6.6919779198
1073PhosphorylationEEREGYFSGSNLKGD
CCCCCCCCCCCCCHH		32.5928889911
1222PhosphorylationKFSNRDGSRSSTTKL
EEECCCCCCCCCCCC		33.0227017623
1227PhosphorylationDGSRSSTTKLTKGEP
CCCCCCCCCCCCCCC		26.4627017623
1230PhosphorylationRSSTTKLTKGEPSML
CCCCCCCCCCCCHHH		38.2627017623
1302UbiquitinationLISGKVSKTQFGEQK
HHHCCCCCCCCCCCH		49.7023749301
1447PhosphorylationSIYPENKSKILNDLL
ECCCCCHHHHHHHHH		36.1921440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MON2_YEASTMON2physical
16554755
NACB1_YEASTEGD1physical
16554755
MON2_YEASTMON2physical
16429126
DGAT2_YEASTDGA1genetic
16269340
PMT2_YEASTPMT2genetic
16269340
OS9_YEASTYOS9genetic
16269340
ATC3_YEASTDRS2genetic
16269340
KEX1_YEASTKEX1physical
18467557
TPO2_YEASTTPO2physical
18467557
HNM1_YEASTHNM1physical
18467557
HXT1_YEASTHXT1physical
18467557
YMP0_YEASTYMR010Wphysical
18467557
MUP1_YEASTMUP1physical
18467557
SSB2_YEASTSSB2physical
19536198
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
MON2_YEASTMON2physical
20477991
ATC7_YEASTNEO1physical
20477991
ATC7_YEASTNEO1genetic
20477991
ARL1_YEASTARL1genetic
20477991
DOP1_YEASTDOP1physical
20477991
MON2_YEASTMON2physical
20826334
RCY1_YEASTRCY1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
SST2_YEASTSST2genetic
27708008
STB4_YEASTSTB4genetic
27708008
PMS1_YEASTPMS1genetic
27708008
FAR11_YEASTFAR11genetic
27708008
MET22_YEASTMET22genetic
27708008
PCL8_YEASTPCL8genetic
27708008
CALM_YEASTCMD1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
RPN5_YEASTRPN5genetic
27708008
RMRP_YEASTSNM1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
FDFT_YEASTERG9genetic
27708008
ATC7_YEASTNEO1genetic
27708008
PAN1_YEASTPAN1genetic
27708008
BET3_YEASTBET3genetic
27708008
SSL1_YEASTSSL1genetic
27708008
RU1C_YEASTYHC1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
POB3_YEASTPOB3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
LCB1_YEASTLCB1genetic
27708008
LST8_YEASTLST8genetic
27708008
LAS17_YEASTLAS17genetic
27708008
NAB3_YEASTNAB3genetic
27708008
ATC3_YEASTDRS2genetic
27708008
YAD7_YEASTYAL037Wgenetic
27708008
CSG2_YEASTCSG2genetic
27708008
SLT11_YEASTECM2genetic
27708008
ADH5_YEASTADH5genetic
27708008
ICS2_YEASTICS2genetic
27708008
AIM4_YEASTAIM4genetic
27708008
YCU0_YEASTYCR050Cgenetic
27708008
BUD31_YEASTBUD31genetic
27708008
MSH3_YEASTMSH3genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
CYK3_YEASTCYK3genetic
27708008
SDHF3_YEASTSDH7genetic
27708008
SLX8_YEASTSLX8genetic
27708008
MSH4_YEASTMSH4genetic
27708008
OSW7_YEASTOSW7genetic
27708008
RPN14_YEASTRPN14genetic
27708008
MON1_YEASTMON1genetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
CUL3_YEASTCUL3genetic
27708008
RME1_YEASTRME1genetic
27708008
TPC1_YEASTTPC1genetic
27708008
ASK10_YEASTASK10genetic
27708008
GYP2_YEASTMDR1genetic
27708008
SKN1_YEASTSKN1genetic
27708008
ALG10_YEASTDIE2genetic
27708008
TNA1_YEASTTNA1genetic
27708008
YAP3_YEASTYAP3genetic
27708008
RIM4_YEASTRIM4genetic
27708008
NEM1_YEASTNEM1genetic
27708008
VPS29_YEASTVPS29genetic
27708008
FSH1_YEASTFSH1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
IRE1_YEASTIRE1genetic
27708008
HXT4_YEASTHXT4genetic
27708008
YHP7_YEASTYHR097Cgenetic
27708008
CTM1_YEASTCTM1genetic
27708008
KC11_YEASTYCK1genetic
27708008
MNT3_YEASTMNT3genetic
27708008
DOA10_YEASTSSM4genetic
27708008
CSK21_YEASTCKA1genetic
27708008
ALLA_YEASTDAL3genetic
27708008
AP3S_YEASTAPS3genetic
27708008
LPLA_YEASTAIM22genetic
27708008
YJE9_YEASTYJL049Wgenetic
27708008
PEP8_YEASTPEP8genetic
27708008
YUR1_YEASTYUR1genetic
27708008
YAK1_YEASTYAK1genetic
27708008
MNN11_YEASTMNN11genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
FABG_YEASTOAR1genetic
27708008
DCOR_YEASTSPE1genetic
27708008
PXA2_YEASTPXA2genetic
27708008
SAC1_YEASTSAC1genetic
27708008
RL1D1_YEASTUTP30genetic
27708008
YK58_YEASTYKR078Wgenetic
27708008
UBI4P_YEASTUBI4genetic
27708008
YL036_YEASTYLR036Cgenetic
27708008
SWI6_YEASTSWI6genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
ENT2_YEASTENT2genetic
27708008
IRC20_YEASTIRC20genetic
27708008
NDE1_YEASTNDL1genetic
27708008
YL346_YEASTYLR346Cgenetic
27708008
MDM30_YEASTMDM30genetic
27708008
ELO3_YEASTELO3genetic
27708008
SWC7_YEASTSWC7genetic
27708008
RL31B_YEASTRPL31Bgenetic
27708008
YL460_YEASTYLR460Cgenetic
27708008
YMD7_YEASTYML037Cgenetic
27708008
NAB6_YEASTNAB6genetic
27708008
MMT1_YEASTMMT1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
APP1_YEASTAPP1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
PFD4_YEASTGIM3genetic
27708008
ATG3_YEASTATG3genetic
27708008
SIN3_YEASTSIN3genetic
27708008
SKM1_YEASTSKM1genetic
27708008
MSN1_YEASTMSN1genetic
27708008
RTC1_YEASTRTC1genetic
27708008
NRT1_YEASTNRT1genetic
27708008
SFL1_YEASTSFL1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
PMT3_YEASTPMT3genetic
27708008
RAD1_YEASTRAD1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
MKK2_YEASTMKK2genetic
27708008
QCR2_YEASTQCR2genetic
27708008
YMP0_YEASTYMR010Wgenetic
27811238
MON2_YEASTMON2physical
28404745
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND THR-246, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.

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