YK58_YEAST - dbPTM
YK58_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YK58_YEAST
UniProt AC P36158
Protein Name Uncharacterized protein YKR078W
Gene Name YKR078W
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 585
Subcellular Localization
Protein Description
Protein Sequence MENDKASHASPSIGVNEFVVQGEISIDDSERSVKSVSVSISDDEDSKTDVQDNMATPSTRSKFQTDLAIDNRLLEKDPKYKKLFTEKRRRRRPESCINLMTKGKGTGQKDNINDQIFSLRILPGSDLNSLKDSLWIIKISTQPDVEKTIARAFSDFYWLYHQLQNNHWGKTIPPPTRSNILVEKDEFAINHLFMIRNNEKYDPIFNFKPEYIISLQLMAMIKHIFNDKVLRLDSNFIDFISWDDDLPESLQIVVDDSTFTGDKILMTSSQFRELKEFHKQSKKVESITNSHASLIPVTELTEIYISPTKLFSRKDYQRLFQPQSTDNTFNNNDPLIQEWIPKSKTLFTSLSFGSSAPTYQEASTEIQACHDWVSISKEQWKQLLYHVLQYIVDEAVKVNSVINEFTECLKQISLDEVIRANSELFLKFSKLNESFLKKFKGASRQDILKLIILFDENVRFCESFESILNQRLKLGKILSIIEVDLDKKKNFLDKLSPGNNNSNNEDLKIRTAEDEYRIVLKRYNRVKQSWEKIMEDILNERKEFEKREAAEVNSCLKSIRDLNMDEKKHYLQLWQDFVPDEHISQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MENDKASHASPSIG
-CCCCCCCCCCCCCC		25.9028889911
10PhosphorylationNDKASHASPSIGVNE
CCCCCCCCCCCCCCE		17.4728889911
25PhosphorylationFVVQGEISIDDSERS
EEEEEEEEECCCCCC		18.7028889911
29PhosphorylationGEISIDDSERSVKSV
EEEEECCCCCCEEEE		31.0328889911
37PhosphorylationERSVKSVSVSISDDE
CCCEEEEEEEECCCC		19.7629688323
39PhosphorylationSVKSVSVSISDDEDS
CEEEEEEEECCCCCC		14.6328889911
41PhosphorylationKSVSVSISDDEDSKT
EEEEEEECCCCCCCC		31.3521440633
46PhosphorylationSISDDEDSKTDVQDN
EECCCCCCCCCCCCC		35.0921440633
48PhosphorylationSDDEDSKTDVQDNMA
CCCCCCCCCCCCCCC		45.4119779198
87AcetylationYKKLFTEKRRRRRPE
HHHHHHHHHHHHCCH		48.4225381059
95PhosphorylationRRRRRPESCINLMTK
HHHHCCHHHHHHHHC		23.9928889911
129PhosphorylationLPGSDLNSLKDSLWI
CCCCCHHHHHCEEEE		44.0630377154
140PhosphorylationSLWIIKISTQPDVEK
EEEEEEEECCCCHHH		18.9130377154
422PhosphorylationDEVIRANSELFLKFS
HHHHHHCHHHHHHHH		34.3928889911
496PhosphorylationKNFLDKLSPGNNNSN
CCHHHHCCCCCCCCC		36.1817563356
584PhosphorylationFVPDEHISQ------
HCCHHHCCC------		31.5721440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YK58_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YK58_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YK58_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPO75_YEASTSPO75physical
16554755
ACT_YEASTACT1genetic
27708008
KRR1_YEASTKRR1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
CDC53_YEASTCDC53genetic
27708008
COG3_YEASTCOG3genetic
27708008
CDC26_YEASTCDC26genetic
27708008
SMD1_YEASTSMD1genetic
27708008
TEL2_YEASTTEL2genetic
27708008
KTHY_YEASTCDC8genetic
27708008
PRP19_YEASTPRP19genetic
27708008
RPC6_YEASTRPC34genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YK58_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, AND MASSSPECTROMETRY.

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