CDC26_YEAST - dbPTM
CDC26_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDC26_YEAST
UniProt AC P14724
Protein Name Anaphase-promoting complex subunit CDC26
Gene Name CDC26
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 124
Subcellular Localization Nucleus .
Protein Description Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication..
Protein Sequence MIRRAPTTLQLSHDDVTSLIDDLNEQKLKQQLNIEKTKYFQGKNGGSLHSNTDFQDTSQNIEDNNNDNDNDIDEDDDMSSYNDKAASVAHTRVLNSLHLSTDSNTAHETSNANDNHNPFYIREE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MIRRAPTTLQLSHD
-CCCCCCCEEECCHH
38.8728132839
8PhosphorylationMIRRAPTTLQLSHDD
CCCCCCCEEECCHHH
16.0828132839
12PhosphorylationAPTTLQLSHDDVTSL
CCCEEECCHHHHHHH
16.3522369663
17PhosphorylationQLSHDDVTSLIDDLN
ECCHHHHHHHHHHHH
25.4722369663
18PhosphorylationLSHDDVTSLIDDLNE
CCHHHHHHHHHHHHH
24.1522369663
110PhosphorylationSNTAHETSNANDNHN
CCCCCCCCCCCCCCC
30.8428889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDC26_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDC26_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDC26_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC16_YEASTCDC16physical
8895471
CDC20_YEASTCDC20physical
10871278
CDC23_YEASTCDC23physical
10871278
CDC16_YEASTCDC16physical
9348530
CDC23_YEASTCDC23physical
9348530
CDC27_YEASTCDC27physical
9348530
APC10_YEASTDOC1physical
9348530
APC1_YEASTAPC1physical
8895471
CDC23_YEASTCDC23physical
8895471
CDC27_YEASTCDC27physical
8895471
CDC16_YEASTCDC16genetic
9348530
CDC23_YEASTCDC23genetic
9348530
CDC27_YEASTCDC27genetic
9348530
APC10_YEASTDOC1genetic
9348530
RLF2_YEASTRLF2genetic
15821127
CDC23_YEASTCDC23physical
16554755
APC1_YEASTAPC1physical
16554755
CDC16_YEASTCDC16genetic
15911580
UBC4_YEASTUBC4genetic
17314980
SAC3_YEASTSAC3genetic
17314980
SWM1_YEASTSWM1genetic
17314980
DEP1_YEASTDEP1genetic
17314980
UBP3_YEASTUBP3genetic
17314980
REB1_YEASTREB1genetic
17314980
DBF4_YEASTDBF4genetic
17314980
PCNA_YEASTPOL30genetic
17314980
GDIR_YEASTRDI1genetic
17314980
UMP1_YEASTUMP1genetic
17314980
PTA1_YEASTPTA1genetic
17314980
PAT1_YEASTPAT1physical
17634282
CTF8_YEASTCTF8genetic
18036332
CTF18_YEASTCTF18genetic
18036332
UBC2_YEASTRAD6genetic
18036332
ETR1_YEASTETR1genetic
20093466
SNF5_YEASTSNF5genetic
20093466
SAC3_YEASTSAC3genetic
20093466
SWM1_YEASTSWM1genetic
20093466
MND2_YEASTMND2genetic
20093466
SIC1_YEASTSIC1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
RU2A_YEASTLEA1genetic
20093466
TCO89_YEASTTCO89genetic
20093466
HSP7F_YEASTSSE1genetic
20093466
PMA2_YEASTPMA2genetic
20093466
HSP7F_YEASTSSE1genetic
22908312
2ABA_YEASTCDC55genetic
23886942
SNF5_YEASTSNF5genetic
27708008
CTK1_YEASTCTK1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
CDC27_YEASTCDC27genetic
27708008
ORC2_YEASTORC2genetic
27708008
SCC1_YEASTMCD1genetic
27708008
APC11_YEASTAPC11genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC20_YEASTCDC20genetic
27708008
ORC6_YEASTORC6genetic
27708008
CDC23_YEASTCDC23genetic
27708008
CDC16_YEASTCDC16genetic
27708008
MCM1_YEASTMCM1genetic
27708008
APC5_YEASTAPC5genetic
27708008
SEC23_YEASTSEC23genetic
27708008
ETR1_YEASTETR1genetic
27708008
SWM1_YEASTSWM1genetic
27708008
LRP1_YEASTLRP1genetic
27708008
MND2_YEASTMND2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
MAS5_YEASTYDJ1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
YME1_YEASTYME1genetic
27708008
ERD2_YEASTERD2genetic
27708008
SEC7_YEASTSEC7genetic
27708008
SWC4_YEASTSWC4genetic
27708008
SMC3_YEASTSMC3genetic
27708008
SEC22_YEASTSEC22genetic
27708008
DOM34_YEASTDOM34genetic
29158977

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDC26_YEAST

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Related Literatures of Post-Translational Modification

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