| UniProt ID | UBP3_YEAST | |
|---|---|---|
| UniProt AC | Q01477 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 3 | |
| Gene Name | UBP3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 912 | |
| Subcellular Localization | ||
| Protein Description | Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin. Plays a role in regulation of silencing by interacting with SIR4. Also, in conjunction with BRE5, cleaves ubiquitin, leading to the subsequent mono-ubiquitination of SEC23.. | |
| Protein Sequence | MNMQDANKEESYSMYPKTSSPPPPTPTNMQIPIYQAPLQMYGYTQAPYLYPTQIPAYSFNMVNQNQPIYHQSGSPHHLPPQNNINGGSTTNNNNINKKKWHSNGITNNNGSSGNQGANSSGSGMSYNKSHTYHHNYSNNHIPMMASPNSGSNAGMKKQTNSSNGNGSSATSPSYSSYNSSSQYDLYKFDVTKLKNLKENSSNLIQLPLFINTTEAEFAAASVQRYELNMKALNLNSESLENSSVEKSSAHHHTKSHSIPKHNEEVKTETHGEEEDAHDKKPHASKDAHELKKKTEVKKEDAKQDRNEKVIQEPQATVLPVVDKKEPEESVEENTSKTSSPSPSPPAAKSWSAIASDAIKSRQASNKTVSGSMVTKTPISGTTAGVSSTNMAAATIGKSSSPLLSKQPQKKDKKYVPPSTKGIEPLGSIALRMCFDPDFISYVLRNKDVENKIPVHSIIPRGIINRANICFMSSVLQVLLYCKPFIDVINVLSTRNTNSRVGTSSCKLLDACLTMYKQFDKETYEKKFLENADDAEKTTESDAKKSSKSKSFQHCATADAVKPDEFYKTLSTIPKFKDLQWGHQEDAEEFLTHLLDQLHEELISAIDGLTDNEIQNMLQSINDEQLKVFFIRNLSRYGKAEFIKNASPRLKELIEKYGVINDDSTEENGWHEVSGSSKRGKKTKTAAKRTVEIVPSPISKLFGGQFRSVLDIPNNKESQSITLDPFQTIQLDISDAGVNDLETAFKKFSEYELLPFKSSSGNDVEAKKQTFIDKLPQVLLIQFKRFSFINNVNKDNAMTNYNAYNGRIEKIRKKIKYGHELIIPEESMSSITLKNNTSGIDDRRYKLTGVIYHHGVSSDGGHYTADVYHSEHNKWYRIDDVNITELEDDDVLKGGEEASDSRTAYILMYQKRN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 131 | Phosphorylation | MSYNKSHTYHHNYSN CCCCCCCCCCCCCCC | 31.47 | 27017623 | |
| 132 | Phosphorylation | SYNKSHTYHHNYSNN CCCCCCCCCCCCCCC | 8.82 | 27017623 | |
| 137 | Phosphorylation | HTYHHNYSNNHIPMM CCCCCCCCCCCCCEE | 36.15 | 27017623 | |
| 146 | Phosphorylation | NHIPMMASPNSGSNA CCCCEEECCCCCCCC | 13.50 | 24961812 | |
| 149 | Phosphorylation | PMMASPNSGSNAGMK CEEECCCCCCCCCCC | 47.16 | 24961812 | |
| 159 | Phosphorylation | NAGMKKQTNSSNGNG CCCCCCCCCCCCCCC | 46.04 | 21551504 | |
| 161 | Phosphorylation | GMKKQTNSSNGNGSS CCCCCCCCCCCCCCC | 28.68 | 27017623 | |
| 162 | Phosphorylation | MKKQTNSSNGNGSSA CCCCCCCCCCCCCCC | 51.32 | 21551504 | |
| 167 | Phosphorylation | NSSNGNGSSATSPSY CCCCCCCCCCCCCCC | 22.31 | 21551504 | |
| 168 | Phosphorylation | SSNGNGSSATSPSYS CCCCCCCCCCCCCCC | 36.64 | 21440633 | |
| 170 | Phosphorylation | NGNGSSATSPSYSSY CCCCCCCCCCCCCCC | 43.02 | 21440633 | |
| 171 | Phosphorylation | GNGSSATSPSYSSYN CCCCCCCCCCCCCCC | 16.15 | 21440633 | |
| 173 | Phosphorylation | GSSATSPSYSSYNSS CCCCCCCCCCCCCCC | 37.10 | 23749301 | |
| 179 | Phosphorylation | PSYSSYNSSSQYDLY CCCCCCCCCCCCEEE | 24.12 | 30377154 | |
| 194 | Ubiquitination | KFDVTKLKNLKENSS EEEHHHHHCHHCCCC | 62.89 | 15699485 | |
| 197 | Ubiquitination | VTKLKNLKENSSNLI HHHHHCHHCCCCCCE | 65.33 | 15699485 | |
| 230 | Ubiquitination | QRYELNMKALNLNSE HHHHHHHHHHCCCCH | 48.96 | 17644757 | |
| 236 | Phosphorylation | MKALNLNSESLENSS HHHHCCCCHHHCCCC | 31.56 | 24961812 | |
| 238 | Phosphorylation | ALNLNSESLENSSVE HHCCCCHHHCCCCCC | 40.58 | 24961812 | |
| 242 | Phosphorylation | NSESLENSSVEKSSA CCHHHCCCCCCHHHC | 26.78 | 28152593 | |
| 243 | Phosphorylation | SESLENSSVEKSSAH CHHHCCCCCCHHHCC | 45.97 | 28152593 | |
| 246 | Acetylation | LENSSVEKSSAHHHT HCCCCCCHHHCCCCC | 47.78 | 24489116 | |
| 246 | Ubiquitination | LENSSVEKSSAHHHT HCCCCCCHHHCCCCC | 47.78 | 17644757 | |
| 257 | Phosphorylation | HHHTKSHSIPKHNEE CCCCCCCCCCCCCHH | 47.91 | 19823750 | |
| 260 | Ubiquitination | TKSHSIPKHNEEVKT CCCCCCCCCCHHCCC | 58.34 | 19722269 | |
| 308 | Ubiquitination | AKQDRNEKVIQEPQA HHCHHHHHHHCCCCC | 48.46 | 15699485 | |
| 316 | Phosphorylation | VIQEPQATVLPVVDK HHCCCCCEEEEEECC | 19.82 | 21440633 | |
| 323 | Ubiquitination | TVLPVVDKKEPEESV EEEEEECCCCCHHHH | 47.64 | 15699485 | |
| 324 | Ubiquitination | VLPVVDKKEPEESVE EEEEECCCCCHHHHH | 74.22 | 15699485 | |
| 329 | Phosphorylation | DKKEPEESVEENTSK CCCCCHHHHHHCCCC | 32.92 | 20377248 | |
| 334 | Phosphorylation | EESVEENTSKTSSPS HHHHHHCCCCCCCCC | 34.57 | 22890988 | |
| 335 | Phosphorylation | ESVEENTSKTSSPSP HHHHHCCCCCCCCCC | 45.58 | 25521595 | |
| 336 | Ubiquitination | SVEENTSKTSSPSPS HHHHCCCCCCCCCCC | 50.84 | 15699485 | |
| 337 | Phosphorylation | VEENTSKTSSPSPSP HHHCCCCCCCCCCCC | 33.92 | 22369663 | |
| 338 | Phosphorylation | EENTSKTSSPSPSPP HHCCCCCCCCCCCCC | 43.94 | 22890988 | |
| 339 | Phosphorylation | ENTSKTSSPSPSPPA HCCCCCCCCCCCCCC | 34.33 | 22369663 | |
| 341 | Phosphorylation | TSKTSSPSPSPPAAK CCCCCCCCCCCCCHH | 39.70 | 22369663 | |
| 343 | Phosphorylation | KTSSPSPSPPAAKSW CCCCCCCCCCCHHHH | 48.10 | 22890988 | |
| 348 | Ubiquitination | SPSPPAAKSWSAIAS CCCCCCHHHHHHHHH | 55.34 | 15699485 | |
| 349 | Phosphorylation | PSPPAAKSWSAIASD CCCCCHHHHHHHHHH | 22.87 | 21440633 | |
| 351 | Phosphorylation | PPAAKSWSAIASDAI CCCHHHHHHHHHHHH | 19.52 | 21440633 | |
| 355 | Phosphorylation | KSWSAIASDAIKSRQ HHHHHHHHHHHHHCC | 22.82 | 24961812 | |
| 359 | Ubiquitination | AIASDAIKSRQASNK HHHHHHHHHCCCCCC | 41.11 | 15699485 | |
| 360 | Phosphorylation | IASDAIKSRQASNKT HHHHHHHHCCCCCCE | 24.42 | 28889911 | |
| 364 | Phosphorylation | AIKSRQASNKTVSGS HHHHCCCCCCEECCE | 30.44 | 23749301 | |
| 375 | Ubiquitination | VSGSMVTKTPISGTT ECCEEEECCCCCCCC | 40.67 | 17644757 | |
| 386 | Phosphorylation | SGTTAGVSSTNMAAA CCCCCCCCCCCCCHH | 30.44 | 27017623 | |
| 387 | Phosphorylation | GTTAGVSSTNMAAAT CCCCCCCCCCCCHHH | 22.76 | 27017623 | |
| 388 | Phosphorylation | TTAGVSSTNMAAATI CCCCCCCCCCCHHHH | 22.85 | 21551504 | |
| 394 | Phosphorylation | STNMAAATIGKSSSP CCCCCHHHHCCCCCC | 26.07 | 27017623 | |
| 397 | Ubiquitination | MAAATIGKSSSPLLS CCHHHHCCCCCCCCC | 43.23 | 17644757 | |
| 398 | Phosphorylation | AAATIGKSSSPLLSK CHHHHCCCCCCCCCC | 30.73 | 29136822 | |
| 399 | Phosphorylation | AATIGKSSSPLLSKQ HHHHCCCCCCCCCCC | 39.19 | 29136822 | |
| 400 | Phosphorylation | ATIGKSSSPLLSKQP HHHCCCCCCCCCCCC | 27.02 | 22369663 | |
| 404 | Phosphorylation | KSSSPLLSKQPQKKD CCCCCCCCCCCCCCC | 36.61 | 22369663 | |
| 420 | Ubiquitination | KYVPPSTKGIEPLGS CCCCCCCCCCCCCCH | 63.33 | 15699485 | |
| 446 | Ubiquitination | ISYVLRNKDVENKIP HHHHHCCCCCCCCCC | 57.63 | 15699485 | |
| 451 | Ubiquitination | RNKDVENKIPVHSII CCCCCCCCCCHHHCC | 34.58 | 15699485 | |
| 506 | Ubiquitination | RVGTSSCKLLDACLT CCCHHHHHHHHHHHH | 54.77 | 15699485 | |
| 516 | Ubiquitination | DACLTMYKQFDKETY HHHHHHHHHCCHHHH | 33.40 | 15699485 | |
| 525 | Ubiquitination | FDKETYEKKFLENAD CCHHHHHHHHHHCCC | 38.11 | 15699485 | |
| 526 | Ubiquitination | DKETYEKKFLENADD CHHHHHHHHHHCCCH | 43.15 | 15699485 | |
| 536 | Ubiquitination | ENADDAEKTTESDAK HCCCHHHHCCHHHHH | 63.57 | 15699485 | |
| 543 | Ubiquitination | KTTESDAKKSSKSKS HCCHHHHHHCCCCCC | 59.17 | 15699485 | |
| 544 | Ubiquitination | TTESDAKKSSKSKSF CCHHHHHHCCCCCCH | 62.78 | 15699485 | |
| 548 | Phosphorylation | DAKKSSKSKSFQHCA HHHHCCCCCCHHHHC | 35.16 | 30377154 | |
| 549 | Ubiquitination | AKKSSKSKSFQHCAT HHHCCCCCCHHHHCC | 60.05 | 15699485 | |
| 550 | Phosphorylation | KKSSKSKSFQHCATA HHCCCCCCHHHHCCC | 36.91 | 30377154 | |
| 561 | Ubiquitination | CATADAVKPDEFYKT HCCCCCCCHHHHHHH | 48.77 | 15699485 | |
| 567 | Ubiquitination | VKPDEFYKTLSTIPK CCHHHHHHHHHCCCC | 48.59 | 15699485 | |
| 574 | Acetylation | KTLSTIPKFKDLQWG HHHHCCCCCCCCCCC | 62.28 | 24489116 | |
| 638 | Ubiquitination | RNLSRYGKAEFIKNA CCHHHCCCHHHHHCC | 35.49 | 15699485 | |
| 643 | Ubiquitination | YGKAEFIKNASPRLK CCCHHHHHCCCHHHH | 52.35 | 15699485 | |
| 655 | Ubiquitination | RLKELIEKYGVINDD HHHHHHHHHCCCCCC | 40.07 | 15699485 | |
| 663 | Phosphorylation | YGVINDDSTEENGWH HCCCCCCCCCCCCCC | 40.35 | 21440633 | |
| 664 | Phosphorylation | GVINDDSTEENGWHE CCCCCCCCCCCCCCC | 55.07 | 24961812 | |
| 677 | Ubiquitination | HEVSGSSKRGKKTKT CCCCCCCCCCCCCCC | 67.86 | 15699485 | |
| 687 | Ubiquitination | KKTKTAAKRTVEIVP CCCCCCCHHEEEECC | 46.25 | 15699485 | |
| 699 | Ubiquitination | IVPSPISKLFGGQFR ECCCHHHHHHCCEEC | 48.86 | 15699485 | |
| 715 | Ubiquitination | VLDIPNNKESQSITL EEECCCCCCCCCEEE | 66.44 | 15699485 | |
| 745 | Ubiquitination | NDLETAFKKFSEYEL CHHHHHHHHHCCCEE | 50.90 | 15699485 | |
| 746 | Ubiquitination | DLETAFKKFSEYELL HHHHHHHHHCCCEEE | 47.90 | 15699485 | |
| 756 | Ubiquitination | EYELLPFKSSSGNDV CCEEEECCCCCCCCH | 47.70 | 19722269 | |
| 757 | Phosphorylation | YELLPFKSSSGNDVE CEEEECCCCCCCCHH | 30.07 | 25521595 | |
| 758 | Phosphorylation | ELLPFKSSSGNDVEA EEEECCCCCCCCHHH | 42.74 | 25521595 | |
| 759 | Phosphorylation | LLPFKSSSGNDVEAK EEECCCCCCCCHHHH | 49.02 | 25521595 | |
| 766 | Ubiquitination | SGNDVEAKKQTFIDK CCCCHHHHHHHHHHH | 31.72 | 15699485 | |
| 767 | Ubiquitination | GNDVEAKKQTFIDKL CCCHHHHHHHHHHHH | 62.71 | 15699485 | |
| 786 | Phosphorylation | LIQFKRFSFINNVNK EEEEEEHHCCCCCCC | 29.29 | 21440633 | |
| 793 | Ubiquitination | SFINNVNKDNAMTNY HCCCCCCCCCCCCCH | 48.34 | 15699485 | |
| 809 | Ubiquitination | AYNGRIEKIRKKIKY HCCCHHHHHHHHHCC | 45.50 | 15699485 | |
| 837 | Phosphorylation | ITLKNNTSGIDDRRY EEECCCCCCCCCCEE | 35.56 | 28889911 | |
| 910 | Ubiquitination | AYILMYQKRN----- EEEEEEECCC----- | 36.10 | 15699485 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBP3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242; SER-243; SER-339AND SER-400, AND MASS SPECTROMETRY. | |
