dbPTM

TMA46_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TMA46_YEAST
UniProt AC	Q12000
Protein Name	Translation machinery-associated protein 46
Gene Name	TMA46
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	345
Subcellular Localization	Cytoplasm .
Protein Description
Protein Sequence	MPPKKGKQAQAAGKKKDNVDKTFGMKNKNRSTKVQKYIKQVQSQSDPKKEEMRLKKLEEKKRREAEEAERRALFNPVADQRVRAGVDPKSMVCALFKLGNCNKGAKCKFSHDLNVGRRMEKKDLYQDTRSEKENDTMDNWDEEKLRKVILSKHGNPKTTTDKVCKYFIEAVENGKYGWFWICPNGGDKCMYRHSLPEGFVLKTNEQKRLERESLEKQPKITLEEFIETERGKLDKSKLTPITIANFAQWKKDHVIAKINAEKKLSSKRKPTGREIILKMSAENKSFETDNADMPDDVTQGSAWDLTEFTDALKKADHQDDGGIKDYGDGSNPTFDIKKANSATLA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	TKVQKYIKQVQSQSD HHHHHHHHHHHHCCC	41.13	23749301
43	Phosphorylation	KYIKQVQSQSDPKKE HHHHHHHHCCCCCHH	32.56	28889911
45	Phosphorylation	IKQVQSQSDPKKEEM HHHHHHCCCCCHHHH	62.21	21440633
89	Ubiquitination	VRAGVDPKSMVCALF HHCCCCHHHHHHHHH	46.88	23749301
108	Ubiquitination	CNKGAKCKFSHDLNV CCCCCCCCCCCCCCC	49.55	15699485
128	Phosphorylation	KKDLYQDTRSEKEND HHHHHHHCCHHHHCC	22.14	21440633
130	Phosphorylation	DLYQDTRSEKENDTM HHHHHCCHHHHCCCC	55.93	21440633
132	Acetylation	YQDTRSEKENDTMDN HHHCCHHHHCCCCCC	64.16	24489116
144	Ubiquitination	MDNWDEEKLRKVILS CCCCCHHHHHHHHHH	52.09	15699485
147	Ubiquitination	WDEEKLRKVILSKHG CCHHHHHHHHHHHCC	44.02	15699485
152	Ubiquitination	LRKVILSKHGNPKTT HHHHHHHHCCCCCCC	52.68	15699485
157	Ubiquitination	LSKHGNPKTTTDKVC HHHCCCCCCCHHHHH	63.60	15699485
175	Ubiquitination	IEAVENGKYGWFWIC HHHHHCCCCEEEEEC	52.77	17644757
188	Ubiquitination	ICPNGGDKCMYRHSL ECCCCCCCCCEECCC	24.95	17644757
202	Acetylation	LPEGFVLKTNEQKRL CCCCEEECCHHHHHH	43.96	24489116
216	Ubiquitination	LERESLEKQPKITLE HHHHHHHHCCCCCHH	76.75	23749301
235	Ubiquitination	TERGKLDKSKLTPIT HHCCCCCHHHCCCEE	60.98	17644757
237	Ubiquitination	RGKLDKSKLTPITIA CCCCCHHHCCCEEEE	63.22	17644757
237	Acetylation	RGKLDKSKLTPITIA CCCCCHHHCCCEEEE	63.22	24489116
250	Ubiquitination	IANFAQWKKDHVIAK EECHHHHCHHHHEEE	35.92	17644757
251	Ubiquitination	ANFAQWKKDHVIAKI ECHHHHCHHHHEEEC	50.54	17644757
257	Ubiquitination	KKDHVIAKINAEKKL CHHHHEEECCHHHHH	25.93	17644757
298	Phosphorylation	ADMPDDVTQGSAWDL CCCCCCCCCCCCCHH	33.92	19779198
301	Phosphorylation	PDDVTQGSAWDLTEF CCCCCCCCCCHHHHH	19.17	28889911
306	Phosphorylation	QGSAWDLTEFTDALK CCCCCHHHHHHHHHH	26.95	19779198
309	Phosphorylation	AWDLTEFTDALKKAD CCHHHHHHHHHHHCC	17.71	27017623
313	Ubiquitination	TEFTDALKKADHQDD HHHHHHHHHCCCCCC	47.86	17644757
314	Ubiquitination	EFTDALKKADHQDDG HHHHHHHHCCCCCCC	60.95	17644757
324	Ubiquitination	HQDDGGIKDYGDGSN CCCCCCCCCCCCCCC	48.44	17644757
326	Phosphorylation	DDGGIKDYGDGSNPT CCCCCCCCCCCCCCC	16.47	19779198
330	Phosphorylation	IKDYGDGSNPTFDIK CCCCCCCCCCCCCCC	44.36	28889911
337	Ubiquitination	SNPTFDIKKANSATL CCCCCCCCCCCCCCC	47.91	17644757
337	Succinylation	SNPTFDIKKANSATL CCCCCCCCCCCCCCC	47.91	23954790
338	Ubiquitination	NPTFDIKKANSATLA CCCCCCCCCCCCCCC	53.81	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TMA46_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TMA46_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TMA46_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBG1_YEAST	RBG1	physical	16554755
EF3A_YEAST	YEF3	physical	16554755
RBG1_YEAST	RBG1	physical	16702403
SSZ1_YEAST	SSZ1	physical	19536198
GIR2_YEAST	GIR2	genetic	18408161
GCN20_YEAST	GCN20	genetic	18408161
HSP71_YEAST	SSA1	physical	21076151
HSP72_YEAST	SSA2	physical	21076151
RBG1_YEAST	RBG1	physical	21076151
RBG1_YEAST	RBG1	physical	23899355
MPPA_YEAST	MAS2	genetic	27708008
CDC48_YEAST	CDC48	genetic	27708008
CDC53_YEAST	CDC53	genetic	27708008
RPB1_YEAST	RPO21	genetic	27708008
TCPD_YEAST	CCT4	genetic	27708008
TAF12_YEAST	TAF12	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
COG3_YEAST	COG3	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
TAF6_YEAST	TAF6	genetic	27708008
NUP57_YEAST	NUP57	genetic	27708008
RRP3_YEAST	RRP3	genetic	27708008
SED5_YEAST	SED5	genetic	27708008
MED14_YEAST	RGR1	genetic	27708008
BOS1_YEAST	BOS1	genetic	27708008
GPI12_YEAST	GPI12	genetic	27708008
NOP2_YEAST	NOP2	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
BRX1_YEAST	BRX1	genetic	27708008
PGTB2_YEAST	BET2	genetic	27708008
TM108_YEAST	TMA108	physical	27580715
C1TC_YEAST	ADE3	physical	27580715
PYR1_YEAST	URA2	physical	27580715
RL4A_YEAST	RPL4A	physical	27580715
ACAC_YEAST	ACC1	physical	27580715
RL4B_YEAST	RPL4B	physical	27580715
RLA4_YEAST	RPP2B	physical	27580715
UBP3_YEAST	UBP3	physical	27580715
HSP82_YEAST	HSP82	physical	27580715
HSC82_YEAST	HSC82	physical	27580715
PFKA1_YEAST	PFK1	physical	27580715
RL17A_YEAST	RPL17A	physical	27580715
NOT1_YEAST	CDC39	physical	27580715
RL17B_YEAST	RPL17B	physical	27580715
RS14B_YEAST	RPS14B	physical	27580715
RS14A_YEAST	RPS14A	physical	27580715
RS8A_YEAST	RPS8A	physical	27580715
RS8B_YEAST	RPS8A	physical	27580715
XRN1_YEAST	XRN1	physical	27580715
NACA_YEAST	EGD2	physical	27580715
FAS1_YEAST	FAS1	physical	27580715
NEW1_YEAST	NEW1	physical	27580715
VPH1_YEAST	VPH1	physical	27580715
RBG1_YEAST	RBG1	physical	27580715
ERF1_YEAST	SUP45	physical	27580715
EF3B_YEAST	HEF3	physical	27580715
VTC3_YEAST	VTC3	physical	27580715
RL26A_YEAST	RPL26A	physical	27580715
RS21A_YEAST	RPS21A	physical	27580715
RS18A_YEAST	RPS18A	physical	27580715
RS18B_YEAST	RPS18A	physical	27580715
VATA_YEAST	VMA1	physical	27580715
ARB1_YEAST	ARB1	physical	27580715
RLI1_YEAST	RLI1	physical	27580715
C1TM_YEAST	MIS1	physical	27580715
ZUO1_YEAST	ZUO1	physical	27580715
RL15A_YEAST	RPL15A	physical	27580715
PAT1_YEAST	PAT1	physical	27580715
FAS2_YEAST	FAS2	physical	27580715
DCP2_YEAST	DCP2	physical	27580715
RL16B_YEAST	RPL16B	physical	27580715
RS9B_YEAST	RPS9B	physical	27580715
HS150_YEAST	HSP150	physical	27580715
VTC4_YEAST	VTC4	physical	27580715
NAM7_YEAST	NAM7	physical	27580715
TCB3_YEAST	TCB3	physical	27580715
PMG1_YEAST	GPM1	physical	27580715
IF2P_YEAST	FUN12	physical	27580715
GLYC_YEAST	SHM2	physical	27580715
NAB6_YEAST	NAB6	physical	27580715
CDC48_YEAST	CDC48	physical	27580715
TPIS_YEAST	TPI1	physical	27580715
STI1_YEAST	STI1	physical	27580715
HSP77_YEAST	SSC1	physical	27580715
EIF3B_YEAST	PRT1	physical	27580715
IMDH3_YEAST	IMD3	physical	27580715
SIS1_YEAST	SIS1	physical	27580715
SSD1_YEAST	SSD1	physical	27580715
DBP2_YEAST	DBP2	physical	27580715
MAS5_YEAST	YDJ1	physical	27580715
NOT3_YEAST	NOT3	physical	27580715
PDC1_YEAST	PDC1	physical	27580715
RNQ1_YEAST	RNQ1	physical	27580715
PBP1_YEAST	PBP1	physical	27580715
DHH1_YEAST	DHH1	physical	27580715
RLA0_YEAST	RPP0	physical	27580715
RL38_YEAST	RPL38	physical	27580715
IF2G_YEAST	GCD11	physical	27580715
RL23A_YEAST	RPL23A	physical	27580715
RL23B_YEAST	RPL23A	physical	27580715
VATB_YEAST	VMA2	physical	27580715
RL6B_YEAST	RPL6B	physical	27580715
RL6A_YEAST	RPL6A	physical	27580715
EIF3C_YEAST	NIP1	physical	27580715
GLYM_YEAST	SHM1	physical	27580715
PDR5_YEAST	PDR5	physical	27580715
RPB1_YEAST	RPO21	physical	27580715
RL28_YEAST	RPL28	physical	27580715
PBP4_YEAST	PBP4	physical	27580715
RL2A_YEAST	RPL2A	physical	27580715
RL2B_YEAST	RPL2A	physical	27580715
NAT1_YEAST	NAT1	physical	27580715
IF4E_YEAST	CDC33	physical	27580715
VBA4_YEAST	VBA4	physical	27580715
RL30_YEAST	RPL30	physical	27580715
ERF3_YEAST	SUP35	physical	27580715
VDAC1_YEAST	POR1	physical	27580715
PUR2_YEAST	ADE5,7	physical	27580715
RS19A_YEAST	RPS19A	physical	27580715
STM1_YEAST	STM1	physical	27580715
HSP74_YEAST	SSA4	physical	27580715
SLH1_YEAST	SLH1	physical	27580715
RS2_YEAST	RPS2	physical	27580715
EIF3G_YEAST	TIF35	physical	27580715
RS22A_YEAST	RPS22A	physical	27580715
RL9A_YEAST	RPL9A	physical	27580715
GCN1_YEAST	GCN1	physical	27580715
RL14A_YEAST	RPL14A	physical	27580715
MBF1_YEAST	MBF1	physical	27580715
IMDH2_YEAST	IMD2	physical	27580715
BMH1_YEAST	BMH1	physical	27580715
RPA2_YEAST	RPA135	physical	27580715
G6PI_YEAST	PGI1	physical	27580715
BRE5_YEAST	BRE5	physical	27580715
MAP1_YEAST	MAP1	physical	27580715
NUG1_YEAST	NUG1	physical	27580715
ALF_YEAST	FBA1	physical	27580715
RL33B_YEAST	RPL33B	physical	27580715
RLA3_YEAST	RPP1B	physical	27580715
CCR4_YEAST	CCR4	physical	27580715
SYH1_YEAST	SYH1	physical	27580715
RS15_YEAST	RPS15	physical	27580715
NOT5_YEAST	NOT5	physical	27580715
NOT4_YEAST	MOT2	physical	27580715
ADT2_YEAST	PET9	physical	27580715
TCPQ_YEAST	CCT8	physical	27580715
IF4F2_YEAST	TIF4632	physical	27580715
CALM_YEAST	CMD1	physical	27580715
PSP2_YEAST	PSP2	physical	27580715
YL419_YEAST	YLR419W	physical	27580715
TMA46_YEAST	TMA46	physical	27580715
IMDH4_YEAST	IMD4	physical	27580715
RSSA1_YEAST	RPS0A	physical	27580715
DBP10_YEAST	DBP10	physical	27580715
DEF1_YEAST	DEF1	physical	27580715
CISY1_YEAST	CIT1	physical	27580715
HMDH2_YEAST	HMG2	physical	27580715
MAP2_YEAST	MAP2	physical	27580715
RL5_YEAST	RPL5	physical	27580715
HEK2_YEAST	HEK2	physical	27580715
EIF2A_YEAST	YGR054W	physical	27580715
BEM2_YEAST	BEM2	physical	27580715
NAA25_YEAST	MDM20	physical	27580715
ECM32_YEAST	ECM32	physical	27580715
EF1G2_YEAST	TEF4	physical	27580715
SYNC_YEAST	DED81	physical	27580715
HMDH1_YEAST	HMG1	physical	27580715
SEA4_YEAST	SEA4	physical	27580715
MYO2_YEAST	MYO2	physical	27580715
TCB2_YEAST	TCB2	physical	27580715
CRP1_YEAST	CRP1	physical	27580715
ARD1_YEAST	ARD1	physical	27580715
HXKB_YEAST	HXK2	physical	27580715
CHS5_YEAST	CHS5	physical	27580715
LSM12_YEAST	LSM12	physical	27580715
MYO4_YEAST	MYO4	physical	27580715
DOT6_YEAST	DOT6	physical	27580715
EIF3A_YEAST	RPG1	physical	27580715
SKI2_YEAST	SKI2	physical	27580715
NACB1_YEAST	EGD1	physical	27580715
PAM1_YEAST	PAM1	physical	27580715
BMS1_YEAST	BMS1	physical	27580715
SEC16_YEAST	SEC16	physical	27580715
STT4_YEAST	STT4	physical	27580715
MDHP_YEAST	MDH3	physical	27580715
SVL3_YEAST	SVL3	physical	27580715
HRB1_YEAST	HRB1	physical	27580715
MAOM_YEAST	MAE1	physical	27580715
CUE3_YEAST	CUE3	physical	27580715
CIN8_YEAST	CIN8	physical	27580715
YME2_YEAST	YME2	physical	27580715
FKS2_YEAST	GSC2	physical	27580715
MS116_YEAST	MSS116	physical	27580715
TCB1_YEAST	TCB1	physical	27580715
TCPD_YEAST	CCT4	physical	27580715
NAT10_YEAST	KRE33	physical	27580715
RS7B_YEAST	RPS7B	physical	27580715
RLA2_YEAST	RPP2A	physical	27580715
PHB1_YEAST	PHB1	physical	27580715
RL27A_YEAST	RPL27A	physical	27580715
RS4A_YEAST	RPS4A	physical	27580715
RS4B_YEAST	RPS4A	physical	27580715
RL31B_YEAST	RPL31B	physical	27580715
RL31A_YEAST	RPL31A	physical	27580715
SRO9_YEAST	SRO9	physical	27580715
IF2B_YEAST	SUI3	physical	27580715
GRP78_YEAST	KAR2	physical	27580715
PPN1_YEAST	PPN1	physical	27580715
SMY2_YEAST	SMY2	physical	27580715
RS30A_YEAST	RPS30A	physical	27580715
RS30B_YEAST	RPS30A	physical	27580715
KOG1_YEAST	KOG1	physical	27580715
ILV5_YEAST	ILV5	physical	27580715
SYP1_YEAST	SYP1	physical	27580715
6PGD1_YEAST	GND1	physical	27580715
YL032_YEAST	YLL032C	physical	27580715
PTA1_YEAST	PTA1	physical	27580715
BOI2_YEAST	BOI2	physical	27580715
SHE3_YEAST	SHE3	physical	27580715
PPB_YEAST	PHO8	physical	27580715
PUR4_YEAST	ADE6	physical	27580715
PEP3_YEAST	PEP3	physical	27580715
SSBP1_YEAST	SBP1	physical	27580715
TOR1_YEAST	TOR1	physical	27580715
NOP3_YEAST	NPL3	physical	27580715
BRE1_YEAST	BRE1	physical	27580715
SYIC_YEAST	ILS1	physical	27580715
YN8B_YEAST	YNR021W	physical	27580715
ACON_YEAST	ACO1	physical	27580715
SAC1_YEAST	SAC1	physical	27580715
PHB2_YEAST	PHB2	physical	27580715
OST1_YEAST	OST1	physical	27580715
FAP1_YEAST	FAP1	physical	27580715
EBS1_YEAST	EBS1	physical	27580715
MDJ1_YEAST	MDJ1	physical	27580715
CAF40_YEAST	CAF40	physical	27580715
TR120_YEAST	TRS120	physical	27580715
RRP3_YEAST	RRP3	physical	27580715
CMS1_YEAST	CMS1	physical	27580715
MSC3_YEAST	MSC3	physical	27580715
VTS1_YEAST	VTS1	physical	27580715
IF5A1_YEAST	HYP2	physical	27580715
EF3A_YEAST	YEF3	physical	27580715
IF4F1_YEAST	TIF4631	physical	27580715
NCBP1_YEAST	STO1	physical	27580715
SKI3_YEAST	SKI3	physical	27580715
RRB1_YEAST	RRB1	physical	27580715
MRD1_YEAST	MRD1	physical	27580715
UTP20_YEAST	UTP20	physical	27580715
MTR4_YEAST	MTR4	physical	27580715
PFKA2_YEAST	PFK2	physical	27580715
ALDH5_YEAST	ALD5	physical	27580715
SEC13_YEAST	SEC13	physical	27580715
RFC3_YEAST	RFC3	physical	27580715
DPO5_YEAST	POL5	physical	27580715
ENO2_YEAST	ENO2	physical	27580715
ENO1_YEAST	ENO1	physical	27580715
HSP7F_YEAST	SSE1	physical	27580715
RL10_YEAST	RPL10	physical	27580715
RL25_YEAST	RPL25	physical	27580715
RL36B_YEAST	RPL36B	physical	27580715
RL22A_YEAST	RPL22A	physical	27580715
RL11A_YEAST	RPL11A	physical	27580715
RL35A_YEAST	RPL35A	physical	27580715
RL35B_YEAST	RPL35A	physical	27580715
RL18A_YEAST	RPL18A	physical	27580715
RL18B_YEAST	RPL18A	physical	27580715
RL21A_YEAST	RPL21A	physical	27580715
RL24A_YEAST	RPL24A	physical	27580715
RS12_YEAST	RPS12	physical	27580715
RS3A1_YEAST	RPS1A	physical	27580715
RS21B_YEAST	RPS21B	physical	27580715
RSSA2_YEAST	RPS0B	physical	27580715
RS7A_YEAST	RPS7A	physical	27580715
RS28B_YEAST	RPS28B	physical	27580715

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TMA46_YEAST

Related Literatures of Post-Translational Modification