| UniProt ID | FAS2_YEAST | |
|---|---|---|
| UniProt AC | P19097 | |
| Protein Name | Fatty acid synthase subunit alpha | |
| Gene Name | FAS2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1887 | |
| Subcellular Localization | ||
| Protein Description | Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.. | |
| Protein Sequence | MKPEVEQELAHILLTELLAYQFASPVRWIETQDVFLKDFNTERVVEIGPSPTLAGMAQRTLKNKYESYDAALSLHREILCYSKDAKEIYYTPDPSELAAKEEPAKEEAPAPTPAASAPAPAAAAPAPVAAAAPAAAAAEIADEPVKASLLLHVLVAHKLKKSLDSIPMSKTIKDLVGGKSTVQNEILGDLGKEFGTTPEKPEETPLEELAETFQDTFSGALGKQSSSLLSRLISSKMPGGFTITVARKYLQTRWGLPSGRQDGVLLVALSNEPAARLGSEADAKAFLDSMAQKYASIVGVDLSSAASASGAAGAGAAAGAAMIDAGALEEITKDHKVLARQQLQVLARYLKMDLDNGERKFLKEKDTVAELQAQLDYLNAELGEFFVNGVATSFSRKKARTFDSSWNWAKQSLLSLYFEIIHGVLKNVDREVVSEAINIMNRSNDALIKFMEYHISNTDETKGENYQLVKTLGEQLIENCKQVLDVDPVYKDVAKPTGPKTAIDKNGNITYSEEPREKVRKLSQYVQEMALGGPITKESQPTIEEDLTRVYKAISAQADKQDISSSTRVEFEKLYSDLMKFLESSKEIDPSQTTQLAGMDVEDALDKDSTKEVASLPNKSTISKTVSSTIPRETIPFLHLRKKTPAGDWKYDRQLSSLFLDGLEKAAFNGVTFKDKYVLITGAGKGSIGAEVLQGLLQGGAKVVVTTSRFSKQVTDYYQSIYAKYGAKGSTLIVVPFNQGSKQDVEALIEFIYDTEKNGGLGWDLDAIIPFAAIPEQGIELEHIDSKSEFAHRIMLTNILRMMGCVKKQKSARGIETRPAQVILPMSPNHGTFGGDGMYSESKLSLETLFNRWHSESWANQLTVCGAIIGWTRGTGLMSANNIIAEGIEKMGVRTFSQKEMAFNLLGLLTPEVVELCQKSPVMADLNGGLQFVPELKEFTAKLRKELVETSEVRKAVSIETALEHKVVNGNSADAAYAQVEIQPRANIQLDFPELKPYKQVKQIAPAELEGLLDLERVIVVTGFAEVGPWGSARTRWEMEAFGEFSLEGCVEMAWIMGFISYHNGNLKGRPYTGWVDSKTKEPVDDKDVKAKYETSILEHSGIRLIEPELFNGYNPEKKEMIQEVIVEEDLEPFEASKETAEQFKHQHGDKVDIFEIPETGEYSVKLLKGATLYIPKALRFDRLVAGQIPTGWNAKTYGISDDIISQVDPITLFVLVSVVEAFIASGITDPYEMYKYVHVSEVGNCSGSGMGGVSALRGMFKDRFKDEPVQNDILQESFINTMSAWVNMLLISSSGPIKTPVGACATSVESVDIGVETILSGKARICIVGGYDDFQEEGSFEFGNMKATSNTLEEFEHGRTPAEMSRPATTTRNGFMEAQGAGIQIIMQADLALKMGVPIYGIVAMAATATDKIGRSVPAPGKGILTTAREHHSSVKYASPNLNMKYRKRQLVTREAQIKDWVENELEALKLEAEEIPSEDQNEFLLERTREIHNEAESQLRAAQQQWGNDFYKRDPRIAPLRGALATYGLTIDDLGVASFHGTSTKANDKNESATINEMMKHLGRSEGNPVIGVFQKFLTGHPKGAAGAWMMNGALQILNSGIIPGNRNADNVDKILEQFEYVLYPSKTLKTDGVRAVSITSFGFGQKGGQAIVVHPDYLYGAITEDRYNEYVAKVSAREKSAYKFFHNGMIYNKLFVSKEHAPYTDELEEDVYLDPLARVSKDKKSGSLTFNSKNIQSKDSYINANTIETAKMIENMTKEKVSNGGVGVDVELITSINVENDTFIERNFTPQEIEYCSAQPSVQSSFAGTWSAKEAVFKSLGVKSLGGGAALKDIEIVRVNKNAPAVELHGNAKKAAEEAGVTDVKVSISHDDLQAVAVAVSTKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 37 | Acetylation | ETQDVFLKDFNTERV EECCEEECCCCCCEE | 49.13 | 24489116 | |
| 37 | Ubiquitination | ETQDVFLKDFNTERV EECCEEECCCCCCEE | 49.13 | 23749301 | |
| 50 | Phosphorylation | RVVEIGPSPTLAGMA EEEEECCCHHHHHHH | 25.88 | 22369663 | |
| 52 | Phosphorylation | VEIGPSPTLAGMAQR EEECCCHHHHHHHHH | 33.31 | 22369663 | |
| 62 | Acetylation | GMAQRTLKNKYESYD HHHHHHHHHHHHHHH | 51.27 | 24489116 | |
| 62 | Ubiquitination | GMAQRTLKNKYESYD HHHHHHHHHHHHHHH | 51.27 | 17644757 | |
| 64 | 2-Hydroxyisobutyrylation | AQRTLKNKYESYDAA HHHHHHHHHHHHHHH | 49.13 | - | |
| 64 | Acetylation | AQRTLKNKYESYDAA HHHHHHHHHHHHHHH | 49.13 | 24489116 | |
| 64 | Ubiquitination | AQRTLKNKYESYDAA HHHHHHHHHHHHHHH | 49.13 | 23749301 | |
| 65 | Phosphorylation | QRTLKNKYESYDAAL HHHHHHHHHHHHHHH | 21.36 | 22369663 | |
| 67 | Phosphorylation | TLKNKYESYDAALSL HHHHHHHHHHHHHHH | 25.81 | 22369663 | |
| 68 | Phosphorylation | LKNKYESYDAALSLH HHHHHHHHHHHHHHH | 9.54 | 22369663 | |
| 73 | Phosphorylation | ESYDAALSLHREILC HHHHHHHHHHHHHHE | 19.87 | 22369663 | |
| 83 | Acetylation | REILCYSKDAKEIYY HHHHEEECCCCEEEE | 34.92 | 24489116 | |
| 83 | Ubiquitination | REILCYSKDAKEIYY HHHHEEECCCCEEEE | 34.92 | 23749301 | |
| 86 | Acetylation | LCYSKDAKEIYYTPD HEEECCCCEEEECCC | 55.57 | 24489116 | |
| 86 | Succinylation | LCYSKDAKEIYYTPD HEEECCCCEEEECCC | 55.57 | 23954790 | |
| 86 | Ubiquitination | LCYSKDAKEIYYTPD HEEECCCCEEEECCC | 55.57 | 23749301 | |
| 91 | Phosphorylation | DAKEIYYTPDPSELA CCCEEEECCCHHHHH | 12.30 | 25752575 | |
| 95 | Phosphorylation | IYYTPDPSELAAKEE EEECCCHHHHHCCCC | 53.26 | 28889911 | |
| 100 | Acetylation | DPSELAAKEEPAKEE CHHHHHCCCCCCCCC | 57.93 | 24489116 | |
| 105 | Ubiquitination | AAKEEPAKEEAPAPT HCCCCCCCCCCCCCC | 67.80 | 23749301 | |
| 148 | Phosphorylation | ADEPVKASLLLHVLV CCCHHHHHHHHHHHH | 17.52 | 23749301 | |
| 158 | Ubiquitination | LHVLVAHKLKKSLDS HHHHHHHHHHHCHHC | 52.87 | 23749301 | |
| 161 | Ubiquitination | LVAHKLKKSLDSIPM HHHHHHHHCHHCCCC | 67.69 | 23749301 | |
| 162 | Phosphorylation | VAHKLKKSLDSIPMS HHHHHHHCHHCCCCC | 35.50 | 21440633 | |
| 170 | Acetylation | LDSIPMSKTIKDLVG HHCCCCCCCHHHHHC | 48.28 | 24489116 | |
| 170 | Ubiquitination | LDSIPMSKTIKDLVG HHCCCCCCCHHHHHC | 48.28 | 23749301 | |
| 173 | Acetylation | IPMSKTIKDLVGGKS CCCCCCHHHHHCCCH | 50.68 | 24489116 | |
| 173 | Succinylation | IPMSKTIKDLVGGKS CCCCCCHHHHHCCCH | 50.68 | 23954790 | |
| 180 | O-(pantetheine 4'-phosphoryl)serine | KDLVGGKSTVQNEIL HHHHCCCHHHHHHHH | 36.77 | - | |
| 180 | Phosphorylation | KDLVGGKSTVQNEIL HHHHCCCHHHHHHHH | 36.77 | 22369663 | |
| 181 | Phosphorylation | DLVGGKSTVQNEILG HHHCCCHHHHHHHHH | 29.60 | 22369663 | |
| 196 | Phosphorylation | DLGKEFGTTPEKPEE HHHHHHCCCCCCCCC | 44.49 | 27738172 | |
| 200 | Acetylation | EFGTTPEKPEETPLE HHCCCCCCCCCCCHH | 59.96 | 24489116 | |
| 204 | Phosphorylation | TPEKPEETPLEELAE CCCCCCCCCHHHHHH | 31.35 | 27738172 | |
| 226 | Phosphorylation | GALGKQSSSLLSRLI HHHCHHHHHHHHHHH | 23.63 | 21440633 | |
| 236 | Ubiquitination | LSRLISSKMPGGFTI HHHHHHCCCCCCEEE | 42.18 | 23749301 | |
| 284 | Acetylation | LGSEADAKAFLDSMA CCCHHHHHHHHHHHH | 39.97 | 24489116 | |
| 351 | Acetylation | QVLARYLKMDLDNGE HHHHHHHCCCCCCCC | 22.79 | 24489116 | |
| 351 | Succinylation | QVLARYLKMDLDNGE HHHHHHHCCCCCCCC | 22.79 | 23954790 | |
| 351 | Ubiquitination | QVLARYLKMDLDNGE HHHHHHHCCCCCCCC | 22.79 | 23749301 | |
| 401 | Phosphorylation | FSRKKARTFDSSWNW CCHHHCCCCCCCCHH | 36.33 | 24961812 | |
| 404 | Phosphorylation | KKARTFDSSWNWAKQ HHCCCCCCCCHHHHH | 32.82 | 24961812 | |
| 405 | Phosphorylation | KARTFDSSWNWAKQS HCCCCCCCCHHHHHH | 26.69 | 24961812 | |
| 410 | Ubiquitination | DSSWNWAKQSLLSLY CCCCHHHHHHHHHHH | 31.84 | 17644757 | |
| 426 | Ubiquitination | EIIHGVLKNVDREVV HHHHHHHCCCCHHHH | 53.14 | 17644757 | |
| 443 | Phosphorylation | AINIMNRSNDALIKF HHHHHHHCCHHHHHH | 33.77 | 28889911 | |
| 449 | Acetylation | RSNDALIKFMEYHIS HCCHHHHHHHHHHCC | 39.24 | 24489116 | |
| 456 | Phosphorylation | KFMEYHISNTDETKG HHHHHHCCCCCCCCC | 21.99 | 19779198 | |
| 462 | Acetylation | ISNTDETKGENYQLV CCCCCCCCCCHHHHH | 63.28 | 24489116 | |
| 462 | Ubiquitination | ISNTDETKGENYQLV CCCCCCCCCCHHHHH | 63.28 | 23749301 | |
| 470 | Ubiquitination | GENYQLVKTLGEQLI CCHHHHHHHHHHHHH | 46.77 | 17644757 | |
| 481 | Ubiquitination | EQLIENCKQVLDVDP HHHHHHHHHHCCCCC | 55.83 | 23749301 | |
| 491 | Acetylation | LDVDPVYKDVAKPTG CCCCCHHCCCCCCCC | 46.06 | 24489116 | |
| 491 | Succinylation | LDVDPVYKDVAKPTG CCCCCHHCCCCCCCC | 46.06 | 23954790 | |
| 491 | Ubiquitination | LDVDPVYKDVAKPTG CCCCCHHCCCCCCCC | 46.06 | 23749301 | |
| 495 | Acetylation | PVYKDVAKPTGPKTA CHHCCCCCCCCCCCE | 42.85 | 24489116 | |
| 495 | Ubiquitination | PVYKDVAKPTGPKTA CHHCCCCCCCCCCCE | 42.85 | 23749301 | |
| 505 | Acetylation | GPKTAIDKNGNITYS CCCCEECCCCCEECC | 61.72 | 24489116 | |
| 505 | Succinylation | GPKTAIDKNGNITYS CCCCEECCCCCEECC | 61.72 | 23954790 | |
| 505 | Ubiquitination | GPKTAIDKNGNITYS CCCCEECCCCCEECC | 61.72 | 23749301 | |
| 518 | Ubiquitination | YSEEPREKVRKLSQY CCCCHHHHHHHHHHH | 48.93 | 17644757 | |
| 521 | Acetylation | EPREKVRKLSQYVQE CHHHHHHHHHHHHHH | 56.32 | 24489116 | |
| 521 | Ubiquitination | EPREKVRKLSQYVQE CHHHHHHHHHHHHHH | 56.32 | 23749301 | |
| 523 | Phosphorylation | REKVRKLSQYVQEMA HHHHHHHHHHHHHHH | 23.62 | 22369663 | |
| 525 | Phosphorylation | KVRKLSQYVQEMALG HHHHHHHHHHHHHCC | 10.75 | 22369663 | |
| 536 | Phosphorylation | MALGGPITKESQPTI HHCCCCCCCCCCCCH | 31.71 | 22369663 | |
| 537 | Ubiquitination | ALGGPITKESQPTIE HCCCCCCCCCCCCHH | 56.97 | 23749301 | |
| 552 | 2-Hydroxyisobutyrylation | EDLTRVYKAISAQAD HHHHHHHHHHHHHCC | 36.07 | - | |
| 552 | Acetylation | EDLTRVYKAISAQAD HHHHHHHHHHHHHCC | 36.07 | 24489116 | |
| 552 | Ubiquitination | EDLTRVYKAISAQAD HHHHHHHHHHHHHCC | 36.07 | 23749301 | |
| 555 | Phosphorylation | TRVYKAISAQADKQD HHHHHHHHHHCCCCC | 21.13 | 25752575 | |
| 560 | Acetylation | AISAQADKQDISSST HHHHHCCCCCCCCCC | 53.54 | 24489116 | |
| 560 | Succinylation | AISAQADKQDISSST HHHHHCCCCCCCCCC | 53.54 | 23954790 | |
| 560 | Ubiquitination | AISAQADKQDISSST HHHHHCCCCCCCCCC | 53.54 | 23749301 | |
| 564 | Phosphorylation | QADKQDISSSTRVEF HCCCCCCCCCCHHHH | 26.90 | 23749301 | |
| 565 | Phosphorylation | ADKQDISSSTRVEFE CCCCCCCCCCHHHHH | 35.74 | 23749301 | |
| 566 | Phosphorylation | DKQDISSSTRVEFEK CCCCCCCCCHHHHHH | 17.28 | 23749301 | |
| 567 | Phosphorylation | KQDISSSTRVEFEKL CCCCCCCCHHHHHHH | 40.45 | 28889911 | |
| 573 | Acetylation | STRVEFEKLYSDLMK CCHHHHHHHHHHHHH | 59.03 | 24489116 | |
| 573 | Ubiquitination | STRVEFEKLYSDLMK CCHHHHHHHHHHHHH | 59.03 | 23749301 | |
| 576 | Phosphorylation | VEFEKLYSDLMKFLE HHHHHHHHHHHHHHH | 34.40 | 21440633 | |
| 580 | Acetylation | KLYSDLMKFLESSKE HHHHHHHHHHHHCCC | 54.84 | 24489116 | |
| 580 | Ubiquitination | KLYSDLMKFLESSKE HHHHHHHHHHHHCCC | 54.84 | 23749301 | |
| 586 | Acetylation | MKFLESSKEIDPSQT HHHHHHCCCCCHHHH | 68.89 | 24489116 | |
| 586 | Ubiquitination | MKFLESSKEIDPSQT HHHHHHCCCCCHHHH | 68.89 | 17644757 | |
| 591 | Phosphorylation | SSKEIDPSQTTQLAG HCCCCCHHHHHHHCC | 36.09 | 22369663 | |
| 593 | Phosphorylation | KEIDPSQTTQLAGMD CCCCHHHHHHHCCCC | 22.35 | 22369663 | |
| 594 | Phosphorylation | EIDPSQTTQLAGMDV CCCHHHHHHHCCCCH | 17.59 | 22369663 | |
| 607 | Acetylation | DVEDALDKDSTKEVA CHHHHCCCCCHHHHH | 55.20 | 24489116 | |
| 607 | Ubiquitination | DVEDALDKDSTKEVA CHHHHCCCCCHHHHH | 55.20 | 23749301 | |
| 609 | Phosphorylation | EDALDKDSTKEVASL HHHCCCCCHHHHHCC | 47.31 | 22369663 | |
| 610 | Phosphorylation | DALDKDSTKEVASLP HHCCCCCHHHHHCCC | 41.16 | 22369663 | |
| 611 | Acetylation | ALDKDSTKEVASLPN HCCCCCHHHHHCCCC | 54.89 | 24489116 | |
| 611 | Ubiquitination | ALDKDSTKEVASLPN HCCCCCHHHHHCCCC | 54.89 | 17644757 | |
| 615 | Phosphorylation | DSTKEVASLPNKSTI CCHHHHHCCCCCCCC | 49.92 | 21440633 | |
| 619 | Ubiquitination | EVASLPNKSTISKTV HHHCCCCCCCCCCHH | 47.22 | 23749301 | |
| 620 | Phosphorylation | VASLPNKSTISKTVS HHCCCCCCCCCCHHC | 37.30 | 23749301 | |
| 621 | Phosphorylation | ASLPNKSTISKTVSS HCCCCCCCCCCHHCC | 30.77 | 21551504 | |
| 624 | Acetylation | PNKSTISKTVSSTIP CCCCCCCCHHCCCCC | 49.44 | 24489116 | |
| 624 | Ubiquitination | PNKSTISKTVSSTIP CCCCCCCCHHCCCCC | 49.44 | 23749301 | |
| 650 | Acetylation | KTPAGDWKYDRQLSS CCCCCCCCHHHHHHH | 41.85 | 24489116 | |
| 650 | Ubiquitination | KTPAGDWKYDRQLSS CCCCCCCCHHHHHHH | 41.85 | 23749301 | |
| 656 | Phosphorylation | WKYDRQLSSLFLDGL CCHHHHHHHHHHHHH | 19.36 | 30377154 | |
| 665 | Ubiquitination | LFLDGLEKAAFNGVT HHHHHHHHHHHCCCE | 50.48 | 23749301 | |
| 674 | Acetylation | AFNGVTFKDKYVLIT HHCCCEECCEEEEEE | 43.90 | 24489116 | |
| 674 | Succinylation | AFNGVTFKDKYVLIT HHCCCEECCEEEEEE | 43.90 | 23954790 | |
| 674 | Ubiquitination | AFNGVTFKDKYVLIT HHCCCEECCEEEEEE | 43.90 | 23749301 | |
| 676 | Acetylation | NGVTFKDKYVLITGA CCCEECCEEEEEECC | 37.54 | 24489116 | |
| 676 | Ubiquitination | NGVTFKDKYVLITGA CCCEECCEEEEEECC | 37.54 | 15699485 | |
| 685 | Ubiquitination | VLITGAGKGSIGAEV EEEECCCCCHHHHHH | 49.29 | 17644757 | |
| 702 | Ubiquitination | GLLQGGAKVVVTTSR HHHHCCCEEEEECHH | 38.55 | 17644757 | |
| 711 | Phosphorylation | VVTTSRFSKQVTDYY EEECHHHHHHHHHHH | 22.52 | 23749301 | |
| 712 | 2-Hydroxyisobutyrylation | VTTSRFSKQVTDYYQ EECHHHHHHHHHHHH | 46.18 | - | |
| 712 | Acetylation | VTTSRFSKQVTDYYQ EECHHHHHHHHHHHH | 46.18 | 24489116 | |
| 712 | Ubiquitination | VTTSRFSKQVTDYYQ EECHHHHHHHHHHHH | 46.18 | 23749301 | |
| 724 | Acetylation | YYQSIYAKYGAKGST HHHHHHHHHCCCCCE | 27.52 | 24489116 | |
| 724 | Ubiquitination | YYQSIYAKYGAKGST HHHHHHHHHCCCCCE | 27.52 | 23749301 | |
| 728 | Ubiquitination | IYAKYGAKGSTLIVV HHHHHCCCCCEEEEE | 49.37 | 23749301 | |
| 742 | Ubiquitination | VPFNQGSKQDVEALI EECCCCCHHHHHHHH | 58.29 | 17644757 | |
| 757 | Ubiquitination | EFIYDTEKNGGLGWD HHHHHCCCCCCCCCC | 64.09 | 17644757 | |
| 787 | Ubiquitination | ELEHIDSKSEFAHRI CCEECCCHHHHHHHH | 50.70 | 17644757 | |
| 807 | Acetylation | LRMMGCVKKQKSARG HHHHCCHHCCCCCCC | 54.27 | 25381059 | |
| 807 | Ubiquitination | LRMMGCVKKQKSARG HHHHCCHHCCCCCCC | 54.27 | 23749301 | |
| 808 | Acetylation | RMMGCVKKQKSARGI HHHCCHHCCCCCCCC | 42.43 | 25381059 | |
| 811 | Phosphorylation | GCVKKQKSARGIETR CCHHCCCCCCCCCCC | 22.24 | 24961812 | |
| 817 | Phosphorylation | KSARGIETRPAQVIL CCCCCCCCCCEEEEE | 39.78 | 22369663 | |
| 827 | Phosphorylation | AQVILPMSPNHGTFG EEEEEECCCCCCCCC | 22.17 | 22369663 | |
| 832 | Phosphorylation | PMSPNHGTFGGDGMY ECCCCCCCCCCCCCC | 16.14 | 22369663 | |
| 839 | Phosphorylation | TFGGDGMYSESKLSL CCCCCCCCCCCHHCH | 18.15 | 22369663 | |
| 840 | Phosphorylation | FGGDGMYSESKLSLE CCCCCCCCCCHHCHH | 26.88 | 22369663 | |
| 842 | Phosphorylation | GDGMYSESKLSLETL CCCCCCCCHHCHHHH | 32.72 | 22369663 | |
| 843 | Ubiquitination | DGMYSESKLSLETLF CCCCCCCHHCHHHHH | 37.74 | 17644757 | |
| 890 | Acetylation | IIAEGIEKMGVRTFS HHHHHHHHHCCCCCC | 38.75 | 24489116 | |
| 890 | Ubiquitination | IIAEGIEKMGVRTFS HHHHHHHHHCCCCCC | 38.75 | 15699485 | |
| 899 | Ubiquitination | GVRTFSQKEMAFNLL CCCCCCHHHHHHHHH | 48.54 | 23749301 | |
| 919 | Ubiquitination | EVVELCQKSPVMADL HHHHHHHHCCCEEEC | 56.59 | 17644757 | |
| 920 | Phosphorylation | VVELCQKSPVMADLN HHHHHHHCCCEEECC | 9.24 | 22369663 | |
| 937 | Acetylation | LQFVPELKEFTAKLR CCCCHHHHHHHHHHH | 49.47 | 24489116 | |
| 937 | Succinylation | LQFVPELKEFTAKLR CCCCHHHHHHHHHHH | 49.47 | 23954790 | |
| 937 | Ubiquitination | LQFVPELKEFTAKLR CCCCHHHHHHHHHHH | 49.47 | 17644757 | |
| 942 | Acetylation | ELKEFTAKLRKELVE HHHHHHHHHHHHHHH | 45.85 | 24489116 | |
| 945 | Acetylation | EFTAKLRKELVETSE HHHHHHHHHHHHCHH | 66.87 | 24489116 | |
| 945 | Ubiquitination | EFTAKLRKELVETSE HHHHHHHHHHHHCHH | 66.87 | 17644757 | |
| 951 | Phosphorylation | RKELVETSEVRKAVS HHHHHHCHHHHHHHC | 22.16 | 23749301 | |
| 955 | Acetylation | VETSEVRKAVSIETA HHCHHHHHHHCHHHH | 59.31 | 22865919 | |
| 955 | Ubiquitination | VETSEVRKAVSIETA HHCHHHHHHHCHHHH | 59.31 | 17644757 | |
| 958 | Phosphorylation | SEVRKAVSIETALEH HHHHHHHCHHHHHHC | 21.40 | 22369663 | |
| 961 | Phosphorylation | RKAVSIETALEHKVV HHHHCHHHHHHCCEE | 34.57 | 22369663 | |
| 966 | Ubiquitination | IETALEHKVVNGNSA HHHHHHCCEECCCCC | 38.20 | 17644757 | |
| 996 | Acetylation | QLDFPELKPYKQVKQ ECCCCCCCCHHHHHH | 44.64 | 24489116 | |
| 996 | Ubiquitination | QLDFPELKPYKQVKQ ECCCCCCCCHHHHHH | 44.64 | 17644757 | |
| 999 | Acetylation | FPELKPYKQVKQIAP CCCCCCHHHHHHHCH | 58.08 | 24489116 | |
| 999 | Succinylation | FPELKPYKQVKQIAP CCCCCCHHHHHHHCH | 58.08 | 23954790 | |
| 999 | Ubiquitination | FPELKPYKQVKQIAP CCCCCCHHHHHHHCH | 58.08 | 23749301 | |
| 1002 | Acetylation | LKPYKQVKQIAPAEL CCCHHHHHHHCHHHH | 33.23 | 24489116 | |
| 1002 | Succinylation | LKPYKQVKQIAPAEL CCCHHHHHHHCHHHH | 33.23 | 23954790 | |
| 1002 | Ubiquitination | LKPYKQVKQIAPAEL CCCHHHHHHHCHHHH | 33.23 | 23749301 | |
| 1068 | Ubiquitination | SYHNGNLKGRPYTGW HHCCCCCCCCCCCCC | 57.80 | 17644757 | |
| 1079 | Acetylation | YTGWVDSKTKEPVDD CCCCCCCCCCCCCCC | 60.18 | 22865919 | |
| 1079 | Ubiquitination | YTGWVDSKTKEPVDD CCCCCCCCCCCCCCC | 60.18 | 17644757 | |
| 1081 | Succinylation | GWVDSKTKEPVDDKD CCCCCCCCCCCCCHH | 64.85 | 23954790 | |
| 1081 | Ubiquitination | GWVDSKTKEPVDDKD CCCCCCCCCCCCCHH | 64.85 | 17644757 | |
| 1087 | Acetylation | TKEPVDDKDVKAKYE CCCCCCCHHHHHHHH | 61.02 | 24489116 | |
| 1087 | Succinylation | TKEPVDDKDVKAKYE CCCCCCCHHHHHHHH | 61.02 | 23954790 | |
| 1087 | Ubiquitination | TKEPVDDKDVKAKYE CCCCCCCHHHHHHHH | 61.02 | 17644757 | |
| 1090 | Ubiquitination | PVDDKDVKAKYETSI CCCCHHHHHHHHHHH | 49.66 | 17644757 | |
| 1092 | 2-Hydroxyisobutyrylation | DDKDVKAKYETSILE CCHHHHHHHHHHHHH | 37.59 | - | |
| 1092 | Acetylation | DDKDVKAKYETSILE CCHHHHHHHHHHHHH | 37.59 | 24489116 | |
| 1092 | Ubiquitination | DDKDVKAKYETSILE CCHHHHHHHHHHHHH | 37.59 | 17644757 | |
| 1114 | Phosphorylation | EPELFNGYNPEKKEM CHHHHCCCCHHHHHH | 28.75 | 23749301 | |
| 1118 | Acetylation | FNGYNPEKKEMIQEV HCCCCHHHHHHHHHH | 56.12 | 24489116 | |
| 1118 | Ubiquitination | FNGYNPEKKEMIQEV HCCCCHHHHHHHHHH | 56.12 | 22817900 | |
| 1119 | Ubiquitination | NGYNPEKKEMIQEVI CCCCHHHHHHHHHHH | 51.34 | 22817900 | |
| 1137 | Phosphorylation | DLEPFEASKETAEQF CCCCHHCCHHHHHHH | 24.67 | 25704821 | |
| 1145 | Acetylation | KETAEQFKHQHGDKV HHHHHHHHHHHCCCE | 41.89 | 24489116 | |
| 1145 | Ubiquitination | KETAEQFKHQHGDKV HHHHHHHHHHHCCCE | 41.89 | 17644757 | |
| 1151 | Acetylation | FKHQHGDKVDIFEIP HHHHHCCCEEEEECC | 46.53 | 24489116 | |
| 1151 | Ubiquitination | FKHQHGDKVDIFEIP HHHHHCCCEEEEECC | 46.53 | 17644757 | |
| 1166 | Acetylation | ETGEYSVKLLKGATL CCCCEEEEEECCCEE | 42.01 | 22865919 | |
| 1166 | Ubiquitination | ETGEYSVKLLKGATL CCCCEEEEEECCCEE | 42.01 | 17644757 | |
| 1169 | 2-Hydroxyisobutyrylation | EYSVKLLKGATLYIP CEEEEEECCCEEEEC | 57.86 | - | |
| 1169 | Acetylation | EYSVKLLKGATLYIP CEEEEEECCCEEEEC | 57.86 | 22865919 | |
| 1177 | Acetylation | GATLYIPKALRFDRL CCEEEECCHHCCCEE | 50.96 | 24489116 | |
| 1177 | Ubiquitination | GATLYIPKALRFDRL CCEEEECCHHCCCEE | 50.96 | 23749301 | |
| 1196 | Ubiquitination | IPTGWNAKTYGISDD CCCCCCCCCCCCCHH | 38.78 | 17644757 | |
| 1247 | Phosphorylation | VSEVGNCSGSGMGGV EHHCCCCCCCCHHHH | 39.74 | 19779198 | |
| 1249 | Phosphorylation | EVGNCSGSGMGGVSA HCCCCCCCCHHHHHH | 14.87 | 19779198 | |
| 1299 | Ubiquitination | ISSSGPIKTPVGACA HCCCCCCCCCCCCCC | 50.32 | 17644757 | |
| 1323 | Acetylation | VETILSGKARICIVG HHHHHCCCCEEEEEE | 30.99 | 22865919 | |
| 1323 | Ubiquitination | VETILSGKARICIVG HHHHHCCCCEEEEEE | 30.99 | 17644757 | |
| 1349 | Phosphorylation | EFGNMKATSNTLEEF ECCCEECCCCCHHHH | 19.59 | 28889911 | |
| 1350 | Phosphorylation | FGNMKATSNTLEEFE CCCEECCCCCHHHHH | 32.45 | 23749301 | |
| 1361 | Phosphorylation | EEFEHGRTPAEMSRP HHHHCCCCHHHHCCC | 31.29 | 22369663 | |
| 1366 | Phosphorylation | GRTPAEMSRPATTTR CCCHHHHCCCCCCCC | 26.98 | 22369663 | |
| 1370 | Phosphorylation | AEMSRPATTTRNGFM HHHCCCCCCCCCCCH | 31.23 | 22369663 | |
| 1371 | Phosphorylation | EMSRPATTTRNGFME HHCCCCCCCCCCCHH | 26.34 | 22369663 | |
| 1372 | Phosphorylation | MSRPATTTRNGFMEA HCCCCCCCCCCCHHC | 20.13 | 22369663 | |
| 1413 | Acetylation | MAATATDKIGRSVPA HHHHHCCCCCCCCCC | 42.58 | 24489116 | |
| 1413 | Ubiquitination | MAATATDKIGRSVPA HHHHHCCCCCCCCCC | 42.58 | 23749301 | |
| 1417 | Phosphorylation | ATDKIGRSVPAPGKG HCCCCCCCCCCCCCC | 27.52 | 21440633 | |
| 1423 | Acetylation | RSVPAPGKGILTTAR CCCCCCCCCCCCCHH | 41.54 | 24489116 | |
| 1423 | Ubiquitination | RSVPAPGKGILTTAR CCCCCCCCCCCCCHH | 41.54 | 23749301 | |
| 1434 | Phosphorylation | TTAREHHSSVKYASP CCHHHHHCCCCCCCC | 38.44 | 21440633 | |
| 1435 | Phosphorylation | TAREHHSSVKYASPN CHHHHHCCCCCCCCC | 20.47 | 21440633 | |
| 1437 | Acetylation | REHHSSVKYASPNLN HHHHCCCCCCCCCCC | 36.73 | 24489116 | |
| 1438 | Phosphorylation | EHHSSVKYASPNLNM HHHCCCCCCCCCCCH | 15.34 | 29734811 | |
| 1440 | Phosphorylation | HSSVKYASPNLNMKY HCCCCCCCCCCCHHH | 15.95 | 22369663 | |
| 1446 | Acetylation | ASPNLNMKYRKRQLV CCCCCCHHHHHHHHH | 40.61 | 24489116 | |
| 1446 | Ubiquitination | ASPNLNMKYRKRQLV CCCCCCHHHHHHHHH | 40.61 | 23749301 | |
| 1449 | Ubiquitination | NLNMKYRKRQLVTRE CCCHHHHHHHHHCCH | 41.21 | 22817900 | |
| 1471 | Ubiquitination | ENELEALKLEAEEIP HHHHHHHHCCHHHCC | 51.86 | 15699485 | |
| 1499 | Phosphorylation | EIHNEAESQLRAAQQ HHHHHHHHHHHHHHH | 41.38 | 28889911 | |
| 1514 | Acetylation | QWGNDFYKRDPRIAP HHCCCHHHCCCCCHH | 50.77 | 24489116 | |
| 1514 | Succinylation | QWGNDFYKRDPRIAP HHCCCHHHCCCCCHH | 50.77 | 23954790 | |
| 1514 | Ubiquitination | QWGNDFYKRDPRIAP HHCCCHHHCCCCCHH | 50.77 | 23749301 | |
| 1547 | Ubiquitination | SFHGTSTKANDKNES EECCCCCCCCCCCHH | 44.98 | 22817900 | |
| 1551 | Acetylation | TSTKANDKNESATIN CCCCCCCCCHHHHHH | 63.52 | 24489116 | |
| 1551 | Ubiquitination | TSTKANDKNESATIN CCCCCCCCCHHHHHH | 63.52 | 23749301 | |
| 1562 | Acetylation | ATINEMMKHLGRSEG HHHHHHHHHHCCCCC | 34.07 | 24489116 | |
| 1562 | Ubiquitination | ATINEMMKHLGRSEG HHHHHHHHHHCCCCC | 34.07 | 15699485 | |
| 1567 | Phosphorylation | MMKHLGRSEGNPVIG HHHHHCCCCCCCCCH | 48.32 | 28889911 | |
| 1578 | Acetylation | PVIGVFQKFLTGHPK CCCHHHHHHHHCCCC | 30.77 | 24489116 | |
| 1578 | Ubiquitination | PVIGVFQKFLTGHPK CCCHHHHHHHHCCCC | 30.77 | 17644757 | |
| 1585 | Ubiquitination | KFLTGHPKGAAGAWM HHHHCCCCCHHHHHH | 56.35 | 23749301 | |
| 1616 | Ubiquitination | RNADNVDKILEQFEY CCCCCHHHHHHHCCE | 44.93 | 17644757 | |
| 1629 | Acetylation | EYVLYPSKTLKTDGV CEEECCCCCCCCCCC | 54.06 | 24489116 | |
| 1629 | Ubiquitination | EYVLYPSKTLKTDGV CEEECCCCCCCCCCC | 54.06 | 22817900 | |
| 1632 | Acetylation | LYPSKTLKTDGVRAV ECCCCCCCCCCCEEE | 50.21 | 22865919 | |
| 1632 | Succinylation | LYPSKTLKTDGVRAV ECCCCCCCCCCCEEE | 50.21 | 23954790 | |
| 1632 | Ubiquitination | LYPSKTLKTDGVRAV ECCCCCCCCCCCEEE | 50.21 | 23749301 | |
| 1640 | Phosphorylation | TDGVRAVSITSFGFG CCCCEEEEEEEECCC | 21.11 | 28152593 | |
| 1642 | Phosphorylation | GVRAVSITSFGFGQK CCEEEEEEEECCCCC | 15.53 | 28152593 | |
| 1649 | Ubiquitination | TSFGFGQKGGQAIVV EEECCCCCCCEEEEE | 66.44 | 17644757 | |
| 1676 | Acetylation | RYNEYVAKVSAREKS CHHHHHHHCCHHHHH | 27.03 | 24489116 | |
| 1676 | Ubiquitination | RYNEYVAKVSAREKS CHHHHHHHCCHHHHH | 27.03 | 17644757 | |
| 1686 | Acetylation | AREKSAYKFFHNGMI HHHHHHHHHHHCCCH | 41.07 | 24489116 | |
| 1686 | Ubiquitination | AREKSAYKFFHNGMI HHHHHHHHHHHCCCH | 41.07 | 23749301 | |
| 1696 | Acetylation | HNGMIYNKLFVSKEH HCCCHHCEEEECCCC | 26.74 | 24489116 | |
| 1696 | Ubiquitination | HNGMIYNKLFVSKEH HCCCHHCEEEECCCC | 26.74 | 23749301 | |
| 1701 | Acetylation | YNKLFVSKEHAPYTD HCEEEECCCCCCCCC | 48.49 | 24489116 | |
| 1701 | Ubiquitination | YNKLFVSKEHAPYTD HCEEEECCCCCCCCC | 48.49 | 23749301 | |
| 1727 | Ubiquitination | ARVSKDKKSGSLTFN HCCCCCCCCCCEEEC | 70.90 | 23749301 | |
| 1728 | Phosphorylation | RVSKDKKSGSLTFNS CCCCCCCCCCEEECC | 39.08 | 22369663 | |
| 1730 | Phosphorylation | SKDKKSGSLTFNSKN CCCCCCCCEEECCCC | 31.18 | 22369663 | |
| 1732 | Phosphorylation | DKKSGSLTFNSKNIQ CCCCCCEEECCCCCC | 23.59 | 22369663 | |
| 1735 | Phosphorylation | SGSLTFNSKNIQSKD CCCEEECCCCCCCCC | 23.92 | 22369663 | |
| 1736 | Acetylation | GSLTFNSKNIQSKDS CCEEECCCCCCCCCC | 60.21 | 24489116 | |
| 1736 | Succinylation | GSLTFNSKNIQSKDS CCEEECCCCCCCCCC | 60.21 | 23954790 | |
| 1736 | Ubiquitination | GSLTFNSKNIQSKDS CCEEECCCCCCCCCC | 60.21 | 23749301 | |
| 1740 | Phosphorylation | FNSKNIQSKDSYINA ECCCCCCCCCCEECC | 34.33 | 23749301 | |
| 1741 | Acetylation | NSKNIQSKDSYINAN CCCCCCCCCCEECCC | 34.03 | 24489116 | |
| 1741 | Succinylation | NSKNIQSKDSYINAN CCCCCCCCCCEECCC | 34.03 | 23954790 | |
| 1741 | Ubiquitination | NSKNIQSKDSYINAN CCCCCCCCCCEECCC | 34.03 | 23749301 | |
| 1744 | Phosphorylation | NIQSKDSYINANTIE CCCCCCCEECCCHHH | 14.34 | 28889911 | |
| 1754 | Acetylation | ANTIETAKMIENMTK CCHHHHHHHHHHHCH | 48.07 | 24489116 | |
| 1754 | Ubiquitination | ANTIETAKMIENMTK CCHHHHHHHHHHHCH | 48.07 | 23749301 | |
| 1761 | Ubiquitination | KMIENMTKEKVSNGG HHHHHHCHHHHHCCC | 44.78 | 23749301 | |
| 1821 | 2-Hydroxyisobutyrylation | SAKEAVFKSLGVKSL CHHHHHHHHCCCEEC | 37.87 | - | |
| 1821 | Acetylation | SAKEAVFKSLGVKSL CHHHHHHHHCCCEEC | 37.87 | 24489116 | |
| 1821 | Ubiquitination | SAKEAVFKSLGVKSL CHHHHHHHHCCCEEC | 37.87 | 22817900 | |
| 1826 | Acetylation | VFKSLGVKSLGGGAA HHHHCCCEECCCCCE | 37.86 | 24489116 | |
| 1826 | Ubiquitination | VFKSLGVKSLGGGAA HHHHCCCEECCCCCE | 37.86 | 23749301 | |
| 1827 | Phosphorylation | FKSLGVKSLGGGAAL HHHCCCEECCCCCEE | 29.82 | 22369663 | |
| 1835 | Acetylation | LGGGAALKDIEIVRV CCCCCEECCEEEEEE | 52.51 | 24489116 | |
| 1835 | Succinylation | LGGGAALKDIEIVRV CCCCCEECCEEEEEE | 52.51 | 23954790 | |
| 1835 | Ubiquitination | LGGGAALKDIEIVRV CCCCCEECCEEEEEE | 52.51 | 22817900 | |
| 1844 | Ubiquitination | IEIVRVNKNAPAVEL EEEEEECCCCCCEEE | 52.18 | 23749301 | |
| 1856 | Ubiquitination | VELHGNAKKAAEEAG EEECCHHHHHHHHHC | 47.12 | 22817900 | |
| 1857 | Ubiquitination | ELHGNAKKAAEEAGV EECCHHHHHHHHHCC | 50.87 | 23749301 | |
| 1870 | Phosphorylation | GVTDVKVSISHDDLQ CCCEEEEEECHHHHH | 16.80 | 22369663 | |
| 1872 | Phosphorylation | TDVKVSISHDDLQAV CEEEEEECHHHHHHH | 17.23 | 22369663 | |
| 1884 | Phosphorylation | QAVAVAVSTKK---- HHHEEEEECCC---- | 25.44 | 27738172 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FAS2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FAS2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FAS2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-523; SER-564;SER-958 AND SER-1440, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-958 AND SER-1440, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY. | |
| "Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase."; Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.; Mol. Cell. Proteomics 6:1896-1906(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-567, AND MASSSPECTROMETRY. | |
