LAG2_YEAST - dbPTM
LAG2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAG2_YEAST
UniProt AC Q92325
Protein Name Cullin-associated NEDD8-dissociated protein 1 homolog
Gene Name LAG2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 660
Subcellular Localization
Protein Description Assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (By similarity). Involved in the aging process. Longevity-assurance protein..
Protein Sequence MSLHISKLIEQYRSTKDNDLKYMLLRQNFKINDIEDELAPLVNELLLPVLVEEQDMEILNLVSFQVLPDLVLSMISDPAAAQLGWVISLICDPLLNQSMIHANRSFVLIETLRNVLQKIENSPHLDYHQPVNSSLEFISKFIVEMKRHMCDVDAAQLSHSLSESNMLIYIESLNLLLKFSFFSDAASPSVMVTLPFDILNDVFTIAQDYSATNTNESIDRITEKLLLTSTQLTHPVDLENLCPKMKYNTLAAVSRIWYKFGPIVDKLFTNRLLPVLFPPQMGEECNVEDVLEIVHNFHPYFSIRRLKDNRPLLSDSTISQLREGLFGMLSILNDSLTRTQNENDHGSDNLIDSDDGFGSDNDPEQQAYLDELVSEGYDENMYDGDTDDEDADDINVEKNDEATKDITETNKILLIFSELHYPQEERFSELLVELQTKIAINTSLIDKILSKETTELPTHNGEIADLNEILNEVKGNKPIRKNVIFCTLAHTLSLQSGSELSVLQLSIEVIDHLLVKNHSNNITRGEQFQLIKLILPHLKTNKSFIDTLKAGNFTQKIDEGVTLRTMILSLLLQLFPLDYSMLGEILPTIARYSVRDKDLGVRDLSFQLLDQILRTYYNYLIGIDWEWYKDDFYQVLQETCIKKDINTNLLLQFPPYLPHD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
246AcetylationENLCPKMKYNTLAAV
HHHCHHHCHHHHHHH		41.2825381059
450PhosphorylationSLIDKILSKETTELP
HHHHHHHCCCCCCCC		31.7319779198
454PhosphorylationKILSKETTELPTHNG
HHHCCCCCCCCCCCC		36.2919779198
458PhosphorylationKETTELPTHNGEIAD
CCCCCCCCCCCCCCH		40.3719779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAG2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
16KNeddylation

19942853
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAG2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOM1_YEASTTOM1physical
16554755
CDC53_YEASTCDC53physical
19763088
RBX1_YEASTHRT1physical
19763088
SKP1_YEASTSKP1physical
19763088
CDC4_YEASTCDC4physical
19763088
DCN1_YEASTDCN1genetic
19763088
RUB1_YEASTRUB1genetic
19763088
CDC53_YEASTCDC53physical
19942853
RUB1_YEASTRUB1genetic
19942853
CDC53_YEASTCDC53genetic
19942853
CUL8_YEASTRTT101physical
19942853
UBC3_YEASTCDC34genetic
27708008
RPN11_YEASTRPN11genetic
27708008
SEC22_YEASTSEC22genetic
27708008
ERO1_YEASTERO1genetic
27708008
GPI2_YEASTGPI2genetic
27708008
RCR1_YEASTRCR1genetic
27708008
H3_YEASTHHT1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
ASK10_YEASTASK10genetic
27708008
AIM17_YEASTAIM17genetic
27708008
MPH1_YEASTMPH1genetic
27708008
YJB6_YEASTYJL016Wgenetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
KTI12_YEASTKTI12genetic
27708008
DGK1_YEASTDGK1genetic
27708008
FMP40_YEASTFMP40genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAG2_YEAST

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Related Literatures of Post-Translational Modification

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