| UniProt ID | CDC4_YEAST | |
|---|---|---|
| UniProt AC | P07834 | |
| Protein Name | Cell division control protein 4 | |
| Gene Name | CDC4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 779 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition.. | |
| Protein Sequence | MGSFPLAEFPLRDIPVPYSYRVSGGIASSGSVTALVTAAGTHRNSSTAKTVETEDGEEDIDEYQRKRAAGSGESTPERSDFKRVKHDNHKTLHPVNLQNTGAASVDNDGLHNLTDISNDAEKLLMSVDDGSAAPSTLSVNMGVASHNVAAPTTVNAATITGSDVSNNVNSATINNPMEEGALPLSPTASSPGTTTPLAKTTKTINNNNNIADLIESKDSIISPEYLSDEIFSAINNNLPHAYFKNLLFRLVANMDRSELSDLGTLIKDNLKRDLITSLPFEISLKIFNYLQFEDIINSLGVSQNWNKIIRKSTSLWKKLLISENFVSPKGFNSLNLKLSQKYPKLSQQDRLRLSFLENIFILKNWYNPKFVPQRTTLRGHMTSVITCLQFEDNYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWALKYAHGGILVSGSTDRTVRVWDIKKGCCTHVFKGHNSTVRCLDIVEYKNIKYIVTGSRDNTLHVWKLPKESSVPDHGEEHDYPLVFHTPEENPYFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQMKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIWNNGECSYATNSASPCAKILGAMYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDANDYSRKFSYHHTNLSAITTFYVSDNILVSGSENQFNIYNLRSGKLVHANILKDADQIWSVNFKGKTLVAAVEKDGQSFLEILDFSKASKINYVSNPVNSSSSSLESISTSLGLTRTTIIP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MGSFPLAEFP -----CCCCCCCCCC | 23.53 | 28889911 | |
| 31 | Phosphorylation | GGIASSGSVTALVTA CCCCCCCCEEEEEEE | 20.45 | 28889911 | |
| 49 | Ubiquitination | HRNSSTAKTVETEDG CCCCCCCEEEECCCC | 53.87 | 17644757 | |
| 53 | Phosphorylation | STAKTVETEDGEEDI CCCEEEECCCCCCCH | 34.73 | 24961812 | |
| 66 | Ubiquitination | DIDEYQRKRAAGSGE CHHHHHHHHHCCCCC | 30.75 | 17644757 | |
| 71 | Phosphorylation | QRKRAAGSGESTPER HHHHHCCCCCCCCCH | 34.36 | 19684113 | |
| 74 | Phosphorylation | RAAGSGESTPERSDF HHCCCCCCCCCHHHC | 53.43 | 19684113 | |
| 75 | Phosphorylation | AAGSGESTPERSDFK HCCCCCCCCCHHHCC | 25.52 | 19684113 | |
| 79 | Phosphorylation | GESTPERSDFKRVKH CCCCCCHHHCCCEEC | 45.82 | 19795423 | |
| 104 | Phosphorylation | LQNTGAASVDNDGLH CCCCCCCCCCCCCCC | 29.48 | 28889911 | |
| 199 | Ubiquitination | GTTTPLAKTTKTINN CCCCCCEEEEEEECC | 65.49 | 22817900 | |
| 202 | Ubiquitination | TPLAKTTKTINNNNN CCCEEEEEEECCCCC | 53.27 | 23749301 | |
| 317 | Ubiquitination | RKSTSLWKKLLISEN HHCHHHHHHHHHCCC | 38.55 | 17644757 | |
| 318 | Ubiquitination | KSTSLWKKLLISENF HCHHHHHHHHHCCCC | 36.62 | 17644757 | |
| 327 | Phosphorylation | LISENFVSPKGFNSL HHCCCCCCCCCCCHH | 19.43 | 21551504 | |
| 329 | Ubiquitination | SENFVSPKGFNSLNL CCCCCCCCCCCHHCH | 69.50 | 17644757 | |
| 478 | Acetylation | IVEYKNIKYIVTGSR EEEECCEEEEEECCC | 38.01 | 24489116 | |
| 703 | Ubiquitination | IYNLRSGKLVHANIL EEECCCCCEEEEEEC | 48.89 | 17644757 | |
| 711 | Ubiquitination | LVHANILKDADQIWS EEEEEECCCHHHEEE | 47.26 | 17644757 | |
| 722 | Ubiquitination | QIWSVNFKGKTLVAA HEEEEEECCCEEEEE | 55.05 | 17644757 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-31, AND MASSSPECTROMETRY. | |
