dbPTM

RCN1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RCN1_YEAST
UniProt AC	P36054
Protein Name	Calcipressin-like protein
Gene Name	RCN1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	211
Subcellular Localization
Protein Description	Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin..
Protein Sequence	MGNIITDTIIITSDKCDIVDNDNVERIQVWLSKNILRKFQINENEPLQLIILKRFKRILLICPSHDISQHVMDASRALEMENFNFSYSLQDGQRNLTKQYLKVPESEKMFLISPPASPPPEFDFSKCEDAPQRHIQSHIQQDQQQRLEASQLLPNNPDKNNNGTFTLLKSKVGAITIDRCPTNDGNGQMQLADHVKTAFPPKSIFDTDDDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGNIITDTIIITS --CCCEECEEEEEEC	24.24	30377154
8	Phosphorylation	MGNIITDTIIITSDK CCCEECEEEEEECCC	12.86	30377154
12	Phosphorylation	ITDTIIITSDKCDIV ECEEEEEECCCCCCC	22.06	30377154
113	Phosphorylation	SEKMFLISPPASPPP HHCCEEECCCCCCCC	27.29	19273587
117	Phosphorylation	FLISPPASPPPEFDF EEECCCCCCCCCCCH	43.65	22369663
125	Phosphorylation	PPPEFDFSKCEDAPQ CCCCCCHHHCCCCCH	37.94	22890988
150	Phosphorylation	QQQRLEASQLLPNNP HHHHHHHHHHCCCCC	16.40	28889911
182	Phosphorylation	ITIDRCPTNDGNGQM EEEECCCCCCCCCCE	49.95	20377248
203	Phosphorylation	KTAFPPKSIFDTDDD HCCCCCHHHCCCCCC	33.97	22890988
207	Phosphorylation	PPKSIFDTDDDD--- CCHHHCCCCCCC---	30.49	22890988

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CDC4	P07834	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RCN1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RCN1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD4_YEAST	RAD4	physical	16554755
COG7_YEAST	COG7	physical	16554755
CANB_YEAST	CNB1	physical	18467557
ENP1_YEAST	ENP1	physical	18719252
FNTA_YEAST	RAM2	physical	18719252
PP2B1_YEAST	CNA1	physical	19285944
YCQ6_YEAST	YCR016W	genetic	20093466
EAF1_YEAST	EAF1	genetic	20093466
IOC3_YEAST	IOC3	genetic	20093466
YFK5_YEAST	YFR035C	genetic	20093466
KIP3_YEAST	KIP3	genetic	20093466
NMA2_YEAST	NMA2	genetic	20093466
YG21_YEAST	YGR053C	genetic	20093466
TWF1_YEAST	TWF1	genetic	20093466
DBF2_YEAST	DBF2	genetic	20093466
TIM13_YEAST	TIM13	genetic	20093466
SNF6_YEAST	SNF6	genetic	20093466
NU133_YEAST	NUP133	genetic	20093466
SMA2_YEAST	SMA2	genetic	20093466
PHO80_YEAST	PHO80	genetic	20093466
LEO1_YEAST	LEO1	genetic	20093466
KCC2_YEAST	CMK2	genetic	18806210
CANB_YEAST	CNB1	physical	22615397
ATC3_YEAST	DRS2	genetic	27708008
AGP1_YEAST	AGP1	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
SNF6_YEAST	SNF6	genetic	27708008
UBX2_YEAST	UBX2	genetic	27708008
PP2B1_YEAST	CNA1	physical	24930733
PP2B2_YEAST	CMP2	physical	24930733

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RCN1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND MASSSPECTROMETRY.	18407956 [Abstract]