ATC3_YEAST - dbPTM
ATC3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATC3_YEAST
UniProt AC P39524
Protein Name Probable phospholipid-transporting ATPase DRS2
Gene Name DRS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1355
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Multi-pass membrane protein .
Protein Description This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly..
Protein Sequence MNDDRETPPKRKPGEDDTLFDIDFLDDTTSHSGSRSKVTNSHANANYIPPSHVLPEETIDLDADDDNIENDVHENLFMSNNHDDQTSWNANRFDSDAYQPQSLRAVKPPGLFARFGNGLKNAFTFKRKKGPESFEMNHYNAVTNNELDDNYLDSRNKFNIKILFNRYILRKNVGDAEGNGEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFFLCTSAIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNSTAEIFSEAHDDFVEKRWIDIRVGDIIRVKSEEPIPADTIILSSSEPEGLCYIETANLDGETNLKIKQSRVETAKFIDVKTLKNMNGKVVSEQPNSSLYTYEGTMTLNDRQIPLSPDQMILRGATLRNTAWIFGLVIFTGHETKLLRNATATPIKRTAVEKIINRQIIALFTVLIVLILISSIGNVIMSTADAKHLSYLYLEGTNKAGLFFKDFLTFWILFSNLVPISLFVTVELIKYYQAFMIGSDLDLYYEKTDTPTVVRTSSLVEELGQIEYIFSDKTGTLTRNIMEFKSCSIAGHCYIDKIPEDKTATVEDGIEVGYRKFDDLKKKLNDPSDEDSPIINDFLTLLATCHTVIPEFQSDGSIKYQAASPDEGALVQGGADLGYKFIIRKPNSVTVLLEETGEEKEYQLLNICEFNSTRKRMSAIFRFPDGSIKLFCKGADTVILERLDDEANQYVEATMRHLEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLIEKNLILIGATAIEDKLQDGVPETIHTLQEAGIKIWVLTGDRQETAINIGMSCRLLSEDMNLLIINEETRDDTERNLLEKINALNEHQLSTHDMNTLALVIDGKSLGFALEPELEDYLLTVAKLCKAVICCRVSPLQKALVVKMVKRKSSSLLLAIGDGANDVSMIQAAHVGVGISGMEGMQAARSADIAVGQFKFLKKLLLVHGSWSYQRISVAILYSFYKNTALYMTQFWYVFANAFSGQSIMESWTMSFYNLFFTVWPPFVIGVFDQFVSSRLLERYPQLYKLGQKGQFFSVYIFWGWIINGFFHSAIVFIGTILIYRYGFALNMHGELADHWSWGVTVYTTSVIIVLGKAALVTNQWTKFTLIAIPGSLLFWLIFFPIYASIFPHANISREYYGVVKHTYGSGVFWLTLIVLPIFALVRDFLWKYYKRMYEPETYHVIQEMQKYNISDSRPHVQQFQNAIRKVRQVQRMKKQRGFAFSQAEEGGQEKIVRMYDTTQKRGKYGELQDASANPFNDNNGLGSNDFESAEPFIENPFADGNQNSNRFSSSRDDISFDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MNDDRETPPKRKPG
-CCCCCCCCCCCCCC		45.8728889911
18PhosphorylationRKPGEDDTLFDIDFL
CCCCCCCCCEEEEEC		41.4622369663
28PhosphorylationDIDFLDDTTSHSGSR
EEEECCCCCCCCCCC		29.8422369663
29PhosphorylationIDFLDDTTSHSGSRS
EEECCCCCCCCCCCC		31.2822369663
30PhosphorylationDFLDDTTSHSGSRSK
EECCCCCCCCCCCCC		20.1122369663
32PhosphorylationLDDTTSHSGSRSKVT
CCCCCCCCCCCCCCC		37.9322369663
34PhosphorylationDTTSHSGSRSKVTNS
CCCCCCCCCCCCCCC		36.0719779198
36PhosphorylationTSHSGSRSKVTNSHA
CCCCCCCCCCCCCCC		32.9224961812
95PhosphorylationWNANRFDSDAYQPQS
CCCCCCCCCCCCCCC		22.7930377154
102PhosphorylationSDAYQPQSLRAVKPP
CCCCCCCCHHCCCCC		26.8928889911
120AcetylationARFGNGLKNAFTFKR
HCCCCCHHCCCCCCC		47.8624489116
133PhosphorylationKRKKGPESFEMNHYN
CCCCCCCCCCCCCCC		29.6427017623
139PhosphorylationESFEMNHYNAVTNNE
CCCCCCCCCCCCCCC		10.3827017623
143PhosphorylationMNHYNAVTNNELDDN
CCCCCCCCCCCCCCC		29.8927017623
535UbiquitinationDLDLYYEKTDTPTVV
CCEEEEECCCCCCEE		35.2617644757
536PhosphorylationLDLYYEKTDTPTVVR
CEEEEECCCCCCEEE		32.9228889911
544PhosphorylationDTPTVVRTSSLVEEL
CCCCEEECHHHHHHH		15.8528889911
556PhosphorylationEELGQIEYIFSDKTG
HHHCCCEEEEECCCC		14.6428889911
559PhosphorylationGQIEYIFSDKTGTLT
CCCEEEEECCCCCEE		28.7428889911
561UbiquitinationIEYIFSDKTGTLTRN
CEEEEECCCCCEEEE		47.8917644757
725PhosphorylationLFCKGADTVILERLD
EEECCCCEEEEEECC		14.6527017623
738PhosphorylationLDDEANQYVEATMRH
CCHHHHHHHHHHHHH		10.4827017623
742PhosphorylationANQYVEATMRHLEDY
HHHHHHHHHHHHHHH		10.9627017623
900UbiquitinationLALVIDGKSLGFALE
EEEEECCEECCCCCC		38.4717644757
919UbiquitinationDYLLTVAKLCKAVIC
HHHHHHHHHHCHHHH		50.5117644757
1287UbiquitinationAEEGGQEKIVRMYDT
HHCCCCEEEEEEEEC		38.3223749301
1297UbiquitinationRMYDTTQKRGKYGEL
EEEECCCCCCCCCCC		62.1123749301
1345PhosphorylationNQNSNRFSSSRDDIS
CCCCCCCCCCCCCCC		24.9422369663
1346PhosphorylationQNSNRFSSSRDDISF
CCCCCCCCCCCCCCC		27.0422369663
1347PhosphorylationNSNRFSSSRDDISFD
CCCCCCCCCCCCCCC		38.2322369663
1352PhosphorylationSSSRDDISFDI----
CCCCCCCCCCC----		24.7022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATC3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATC3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATC3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EF1G1_YEASTCAM1genetic
8247005
EF1G1_YEASTCAM1genetic
8041634
ATC5_YEASTDNF1genetic
12221123
CLH_YEASTCHC1genetic
10601336
GEA2_YEASTGEA2genetic
14734650
POB3_YEASTPOB3physical
16554755
VA0D_YEASTVMA6physical
16429126
CDC50_YEASTCDC50physical
16956384
TRS85_YEASTTRS85genetic
16269340
LEM3_YEASTLEM3genetic
16269340
SEC66_YEASTSEC66genetic
16269340
MSMO_YEASTERG25genetic
16269340
OSH1_YEASTSWH1genetic
16269340
NNF2_YEASTNNF2genetic
16269340
PHO86_YEASTPHO86genetic
16269340
TRS33_YEASTTRS33genetic
16269340
ARF1_YEASTARF1genetic
16269340
YEF3_YEASTYEL043Wgenetic
16269340
PRA1_YEASTYIP3genetic
16269340
TLG2_YEASTTLG2genetic
16269340
ORM2_YEASTORM2genetic
16269340
ERG6_YEASTERG6genetic
16269340
SEC63_YEASTSEC63genetic
16269340
AP3D_YEASTAPL5genetic
16269340
GEF1_YEASTGEF1genetic
16269340
STE24_YEASTSTE24genetic
16269340
TRS20_YEASTTRS20genetic
16269340
MTC4_YEASTMTC4genetic
16269340
YET1_YEASTYET1genetic
16269340
COPE_YEASTSEC28genetic
16269340
NEM1_YEASTNEM1genetic
16269340
KEX1_YEASTKEX1genetic
16269340
SWA2_YEASTSWA2genetic
16269340
GIP3_YEASTGIP3genetic
16269340
GDA1_YEASTGDA1genetic
16269340
PKR1_YEASTPKR1genetic
16269340
GEA2_YEASTGEA2genetic
16269340
MSC7_YEASTMSC7genetic
16269340
SCS2_YEASTSCS2genetic
16269340
COPB2_YEASTSEC27genetic
16269340
OST5_YEASTOST5genetic
16269340
SCS3_YEASTSCS3genetic
16269340
ERV14_YEASTERV14genetic
16269340
SSO2_YEASTSSO2genetic
16269340
RGP1_YEASTRGP1genetic
16269340
DSL1_YEASTDSL1genetic
16269340
PMT1_YEASTPMT1genetic
16269340
AP3S_YEASTAPS3genetic
16269340
SEC72_YEASTSEC72genetic
16269340
YET3_YEASTYET3genetic
16269340
AGE2_YEASTAGE2genetic
16269340
ARF2_YEASTARF2genetic
16269340
GYP1_YEASTGYP1genetic
16269340
DOP1_YEASTDOP1genetic
16269340
CYB5_YEASTCYB5genetic
16269340
GUP1_YEASTGUP1genetic
16269340
GET2_YEASTGET2genetic
16269340
CWH43_YEASTCWH43genetic
16269340
ATC1_YEASTPMR1genetic
16269340
DGK1_YEASTDGK1genetic
16269340
BST1_YEASTBST1genetic
16269340
ICE2_YEASTICE2genetic
16269340
ERG5_YEASTERG5genetic
16269340
ERG4_YEASTERG4genetic
16269340
PAN1_YEASTPAN1genetic
17122361
CHS3_YEASTCHS3physical
18467557
SMI1_YEASTSMI1physical
18467557
ATC5_YEASTDNF1physical
18467557
KEX1_YEASTKEX1physical
18467557
PIN2_YEASTPIN2physical
18467557
SWD1_YEASTSWD1genetic
19061648
LHP1_YEASTLHP1genetic
19061648
THP1_YEASTTHP1genetic
19061648
SIN3_YEASTSIN3genetic
19061648
PFD5_YEASTGIM5genetic
19061648
SSBP1_YEASTSBP1genetic
19061648
ERF3_YEASTSUP35genetic
19061648
SEM1_YEASTSEM1genetic
19061648
NU170_YEASTNUP170genetic
19061648
NCL1_YEASTNCL1genetic
19061648
SHE3_YEASTSHE3genetic
19061648
PSA3_YEASTPRE9genetic
19061648
TRM11_YEASTTRM11genetic
19061648
TSR3_YEASTTSR3genetic
19061648
GSP2_YEASTGSP2genetic
19061648
CAF20_YEASTCAF20genetic
19061648
APQ12_YEASTAPQ12genetic
19061648
CSK21_YEASTCKA1genetic
19061648
RIT1_YEASTRIT1genetic
19061648
YME2_YEASTYME2genetic
19061648
RNH2A_YEASTRNH201genetic
19061648
CDC50_YEASTCDC50physical
19411703
LEM3_YEASTLEM3physical
19411703
AP1G1_YEASTAPL4genetic
18508916
GGA2_YEASTGGA2genetic
18508916
GGA1_YEASTGGA1genetic
18508916
AP1B1_YEASTAPL2physical
18508916
KES1_YEASTKES1genetic
19403696
ERG6_YEASTERG6genetic
19403696
ATC5_YEASTDNF1genetic
19403696
ATC3_YEASTDRS2physical
19968326
CDC50_YEASTCDC50physical
19968326
SAC1_YEASTSAC1physical
19968326
INO1_YEASTINO1physical
19968326
ITR1_YEASTITR1physical
19968326
TCB3_YEASTTCB3physical
19968326
VNX1_YEASTVNX1physical
19968326
SSD1_YEASTSSD1physical
19968326
GRP78_YEASTKAR2physical
19968326
COPB_YEASTSEC26physical
19968326
MHP1_YEASTMHP1physical
19968326
SAC1_YEASTSAC1genetic
19968326
PAN1_YEASTPAN1genetic
10601336
SLA1_YEASTSLA1genetic
17122361
TRS65_YEASTTRS65genetic
15574876
TRS33_YEASTTRS33genetic
15574876
YPT31_YEASTYPT31genetic
15574876
PSS_YEASTCHO1genetic
16956384
CWH43_YEASTCWH43genetic
19325107
GLO3_YEASTGLO3genetic
19325107
HLJ1_YEASTHLJ1genetic
19325107
KEX2_YEASTKEX2genetic
19325107
LHS1_YEASTLHS1genetic
19325107
PMT1_YEASTPMT1genetic
19325107
ELO3_YEASTELO3genetic
19325107
ARL1_YEASTARL1genetic
19325107
COG5_YEASTCOG5genetic
19325107
TRS85_YEASTTRS85genetic
19325107
RGP1_YEASTRGP1genetic
19325107
SWC5_YEASTSWC5genetic
19325107
TLG2_YEASTTLG2genetic
19325107
CDC5_YEASTCDC5physical
21212072
ERG4_YEASTERG4genetic
20526336
ERG5_YEASTERG5genetic
20526336
SEM1_YEASTSEM1genetic
20526336
YPT31_YEASTYPT31genetic
20526336
SUR7_YEASTSUR7genetic
20526336
ELM1_YEASTELM1genetic
20526336
ERG3_YEASTERG3genetic
20526336
ERG6_YEASTERG6genetic
20526336
ERG2_YEASTERG2genetic
20526336
TLG2_YEASTTLG2genetic
20526336
PEP8_YEASTPEP8genetic
20526336
MON2_YEASTMON2genetic
20526336
PER1_YEASTPER1genetic
20526336
SWA2_YEASTSWA2genetic
20526336
THRC_YEASTTHR4genetic
20526336
SCH9_YEASTSCH9genetic
20526336
MTL1_YEASTMTL1genetic
20526336
YP150_YEASTYPL150Wgenetic
20526336
LEM3_YEASTLEM3genetic
20526336
AP18B_YEASTYAP1802genetic
20526336
GEF1_YEASTGEF1genetic
20526336
KC11_YEASTYCK1genetic
20526336
KC12_YEASTYCK2genetic
20526336
ATC5_YEASTDNF1genetic
22308393
ATC5_YEASTDNF1genetic
15090616
LEM3_YEASTLEM3genetic
15090616
CDC50_YEASTCDC50physical
15090616
LEM3_YEASTLEM3physical
15090616
LEM3_YEASTLEM3physical
22791719
CDC50_YEASTCDC50physical
22791719
RCY1_YEASTRCY1physical
24272750
ATC5_YEASTDNF1genetic
23709217
ARL1_YEASTARL1physical
23345439
ARL1_YEASTARL1genetic
23345439
ATC5_YEASTDNF1genetic
24019533
CDC50_YEASTCDC50physical
24019533
ATC7_YEASTNEO1genetic
27235400
KES1_YEASTKES1genetic
27811238
YMP0_YEASTYMR010Wgenetic
28057802
KES1_YEASTKES1genetic
28057802
SNG1_YEASTSNG1genetic
27033517
CDC50_YEASTCDC50physical
28302728
CDC50_YEASTCDC50physical
25393116
KES1_YEASTKES1genetic
26466678
ATC5_YEASTDNF1genetic
26466678
COG8_YEASTCOG8genetic
28627726
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATC3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102 AND SER-1347, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1352, AND MASSSPECTROMETRY.

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