PIN2_YEAST - dbPTM
PIN2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PIN2_YEAST
UniProt AC Q12057
Protein Name [PSI+] induction protein 2
Gene Name PIN2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 282
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description Not known. Seems to be able to provoque the non-Mendelian trait [PIN(+)] which is required for the de novo appearance of the [PSI(+)] prion..
Protein Sequence MNVCKLKEIVPLFPRSSFTDGVVSTGKSFRSWDTCMDNKACKIIAIVGIVLACILVIWLIGGLLTCFRQGVTGIGQFICWCCRCSNDRNGNNTMPVNEGFSRVNMGVAPPSTVIYQPIQQPESAYYRNDAKNDTFYDEVKTPSNEVYELEEDFDLEKQKEKTRKKQQKERNKEGRSPSRVAPLVYEEENFEGSSPQPQYDARNSFIQNAANTGSNNAHVASQSPIFDISDYGENYYYDNNNINNNLQGNSYNTPSSNHRSPYPTENYQSYQGYKPNQSDRYY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationIVPLFPRSSFTDGVV
CEECCCCCCCCCCCC		30.0029688323
17PhosphorylationVPLFPRSSFTDGVVS
EECCCCCCCCCCCCC		33.1829688323
19PhosphorylationLFPRSSFTDGVVSTG
CCCCCCCCCCCCCCC		33.5229688323
24PhosphorylationSFTDGVVSTGKSFRS
CCCCCCCCCCCCCCC		29.0929688323
25PhosphorylationFTDGVVSTGKSFRSW
CCCCCCCCCCCCCCC		36.7029688323
28PhosphorylationGVVSTGKSFRSWDTC
CCCCCCCCCCCCCHH		27.5128889911
91N-linked_GlycosylationCSNDRNGNNTMPVNE
CCCCCCCCCCCCCCC		44.33-
131UbiquitinationAYYRNDAKNDTFYDE
HCCCCCCCCCCCCCC		59.2123749301
132N-linked_GlycosylationYYRNDAKNDTFYDEV
CCCCCCCCCCCCCCC		56.10-
134PhosphorylationRNDAKNDTFYDEVKT
CCCCCCCCCCCCCCC		33.2228889911
140UbiquitinationDTFYDEVKTPSNEVY
CCCCCCCCCCCCCEE		53.3124961812
141PhosphorylationTFYDEVKTPSNEVYE
CCCCCCCCCCCCEEE		36.8117330950
143PhosphorylationYDEVKTPSNEVYELE
CCCCCCCCCCEEEHH		51.3521440633
157UbiquitinationEEDFDLEKQKEKTRK
HHHCCHHHHHHHHHH		74.1724961812
185PhosphorylationSRVAPLVYEEENFEG
HHCCCCEEEECCCCC		25.8829136822
193PhosphorylationEEENFEGSSPQPQYD
EECCCCCCCCCCCHH		31.4822369663
194PhosphorylationEENFEGSSPQPQYDA
ECCCCCCCCCCCHHH		38.1122369663
274UbiquitinationYQSYQGYKPNQSDRY
CHHCCCCCCCCCCCC		44.2923749301
276N-linked_GlycosylationSYQGYKPNQSDRYY-
HCCCCCCCCCCCCC-		50.24-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PIN2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PIN2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PIN2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BCH1_YEASTBCH1physical
24656818
BCH2_YEASTBCH2physical
24656818
BUD7_YEASTBUD7physical
24656818
CHS5_YEASTCHS5physical
24656818
CHS6_YEASTCHS6physical
24656818
AP1B1_YEASTAPL2physical
24656818
PIN2_YEASTPIN2physical
24656818
SWC3_YEASTSWC3genetic
27708008
PEX19_YEASTPEX19genetic
27708008
AIM11_YEASTAIM11genetic
27708008
SPO74_YEASTSPO74genetic
27708008
MED20_YEASTSRB2genetic
27708008
IXR1_YEASTIXR1genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
EIF3J_YEASTHCR1genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
CDC73_YEASTCDC73genetic
27708008
HDA1_YEASTHDA1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
NAA30_YEASTMAK3genetic
27708008
CDC37_YEASTCDC37genetic
27708008
STT3_YEASTSTT3genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CLP1_YEASTCLP1genetic
27708008
FUN30_YEASTFUN30genetic
27708008
SLX5_YEASTSLX5genetic
27708008
MTU1_YEASTSLM3genetic
27708008
TRPE_YEASTTRP2genetic
27708008
SLX8_YEASTSLX8genetic
27708008
HUR1_YEASTHUR1genetic
27708008
STB5_YEASTSTB5genetic
27708008
PTH_YEASTPTH1genetic
27708008
CTF8_YEASTCTF8genetic
27708008
FLX1_YEASTFLX1genetic
27708008
ASF1_YEASTASF1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
DBP7_YEASTDBP7genetic
27708008
OAF3_YEASTOAF3genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
RAX2_YEASTRAX2genetic
27708008
UPS1_YEASTUPS1genetic
27708008
MCP2_YEASTMCP2genetic
27708008
YPT6_YEASTYPT6genetic
27708008
TMA10_YEASTTMA10genetic
27708008
YL413_YEASTINA1genetic
27708008
RAD52_YEASTRAD52genetic
27708008
CTF18_YEASTCTF18genetic
27708008
PKR1_YEASTPKR1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
YO268_YEASTYOR268Cgenetic
27708008
HSP7F_YEASTSSE1genetic
27708008
COX10_YEASTCOX10genetic
27708008
THP3_YEASTTHP3genetic
27708008
MED1_YEASTMED1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PIN2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-141, AND MASSSPECTROMETRY.

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