dbPTM

MCP2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MCP2_YEAST
UniProt AC	Q06567
Protein Name	ABC1 family protein MCP2 {ECO:0000305\|PubMed:23781023}
Gene Name	MCP2 {ECO:0000303\|PubMed:23781023}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	569
Subcellular Localization	Mitochondrion . Mitochondrion inner membrane Single-pass membrane protein .
Protein Description	Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression. [PubMed: 25683707 Involved in mitochondrial lipid homeostasis]
Protein Sequence	MMTKAFFNKLPFEVFRRYVRTGKSIPQRSPRTRKSLLVGGTIASAVVLYNFNDTFHDSVKHTALTTKRIAVVTQATTRCFYHYKRALNKSYENKKEREVALNKCHKMCALITLHALRSNGGIYIKLGQHIGAMTYLLPKEWTDTMIPLQDHCPESTYEEIDELFKEDLGTSIEDMFLEFNKTPIGVASLAQVHVAKLKNSDGKGSSVAVKCQHPSLKEFIPLDVMLTRTVFELLDVFFPDYPLTWLGDELQSSIYVELNFTKEAENAEKTRHYFSKFKKQTALKIPKVIESHKRILIMEYVGGKRLDDLEYIDSHGISRSEVSSCLSHIFNNMIFTPNVGIHCDPHGGNLAIRSVKPAKDNGYHNFEIVLFDHGLYRYPSTRTRRLYAKFWLSLLFDKDQTKMKKYAKGFANITDEQFPLLAAAITGRSIDAALNYDISTSRTQEEMDVMANGILEGTLLSDLMSILSRIPRVVLLILKTNDLTRHLDECLQNPLGPERTFLIMTQYCAKTVYDEKVERINSEYARWSIKWMWENLTNWIVYERRINQLYFYDFVLWWKKFIPKTWLSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
181	Ubiquitination	DMFLEFNKTPIGVAS HHHHHCCCCCCCCHH		17644757
196	Ubiquitination	LAQVHVAKLKNSDGK HEEEEEEECCCCCCC		17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MCP2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MCP2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MCP2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BNI4_YEAST	BNI4	genetic	19269370
CG22_YEAST	CLB2	genetic	19269370
MDM10_YEAST	MDM10	genetic	21987634
GEM1_YEAST	GEM1	genetic	21987634
TGL2_YEAST	TGL2	genetic	21987634
UBP4_YEAST	DOA4	genetic	21987634
XRN1_YEAST	XRN1	genetic	21987634
MDM34_YEAST	MDM34	genetic	21987634
PHB1_YEAST	PHB1	genetic	21987634
CBS_YEAST	CYS4	genetic	21987634
MDM31_YEAST	MDM31	genetic	21987634
MMM1_YEAST	MMM1	genetic	21987634
UPS1_YEAST	UPS1	genetic	21987634
VDAC1_YEAST	POR1	genetic	21987634
MDM12_YEAST	MDM12	genetic	21987634
PEP12_YEAST	PEP12	genetic	21987634
MDM32_YEAST	MDM32	genetic	21987634
YME1_YEAST	YME1	genetic	21987634
POP7_YEAST	POP7	genetic	27708008
CDC37_YEAST	CDC37	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
CDC12_YEAST	CDC12	genetic	27708008
FDFT_YEAST	ERG9	genetic	27708008
MOB1_YEAST	MOB1	genetic	27708008
IF2A_YEAST	SUI2	genetic	27708008
SSL1_YEAST	SSL1	genetic	27708008
ORC1_YEAST	ORC1	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
SGT1_YEAST	SGT1	genetic	27708008
TFC8_YEAST	TFC8	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MCP2_YEAST

Related Literatures of Post-Translational Modification