MOB1_YEAST - dbPTM
MOB1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MOB1_YEAST
UniProt AC P40484
Protein Name DBF2 kinase activator protein MOB1
Gene Name MOB1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 314
Subcellular Localization Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Bud neck. Chromosome, centromere. Localizes predominantly to the cytoplasmic surface of the spindle pole body during anaphase and to a ring at the bud neck
Protein Description Functions as an activator subunit for the DBF2 protein kinase. Binds to DBF2, which is required for the phosphorylation and activation of DBF2 by the upstream kinase CDC15 in late anaphase. DBF2-MOB1 is part of the mitotic exit network (MEN) signaling cascade, which regulates release from the nucleus and activity of phosphatase CDC14. Required for inactivation of mitotic cyclin-dependent kinase for exit from mitosis, cytokinesis and G1 gene transcription..
Protein Sequence MSFLQNFHISPGQTIRSTRGFKWNTANAANNAGSVSPTKATPHNNTINGNNNNANTINNRADFTNNPVNGYNESDHGRMSPVLTTPKRHAPPPEQLQNVTDFNYTPSHQKPFLQPQAGTTVTTHQDIKQIVEMTLGSEGVLNQAVKLPRGEDENEWLAVHCVDFYNQINMLYGSITEFCSPQTCPRMIATNEYEYLWAFQKGQPPVSVSAPKYVECLMRWCQDQFDDESLFPSKVTGTFPEGFIQRVIQPILRRLFRVYAHIYCHHFNEILELNLQTVLNTSFRHFCLFAQEFELLRPADFGPLLELVMELRDR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSFLQNFHI
------CCCCCCCCC		34.3622369663
10PhosphorylationFLQNFHISPGQTIRS
CCCCCCCCCCCCCCC		17.8922369663
14PhosphorylationFHISPGQTIRSTRGF
CCCCCCCCCCCCCCC		25.0329734811
17PhosphorylationSPGQTIRSTRGFKWN
CCCCCCCCCCCCCCC		20.7119823750
18PhosphorylationPGQTIRSTRGFKWNT
CCCCCCCCCCCCCCC		25.5919823750
22AcetylationIRSTRGFKWNTANAA
CCCCCCCCCCCCCCC		42.2122865919
25PhosphorylationTRGFKWNTANAANNA
CCCCCCCCCCCCCCC		21.8522890988
34PhosphorylationNAANNAGSVSPTKAT
CCCCCCCCCCCCCCC		19.6022369663
36PhosphorylationANNAGSVSPTKATPH
CCCCCCCCCCCCCCC		28.6622369663
38PhosphorylationNAGSVSPTKATPHNN
CCCCCCCCCCCCCCC		26.2922369663
41PhosphorylationSVSPTKATPHNNTIN
CCCCCCCCCCCCCCC		27.0028889911
46PhosphorylationKATPHNNTINGNNNN
CCCCCCCCCCCCCCC		22.5723749301
56PhosphorylationGNNNNANTINNRADF
CCCCCCCCCCCCHHC		23.7523749301
64PhosphorylationINNRADFTNNPVNGY
CCCCHHCCCCCCCCC		34.3322369663
71PhosphorylationTNNPVNGYNESDHGR
CCCCCCCCCCCCCCC		15.5622369663
74PhosphorylationPVNGYNESDHGRMSP
CCCCCCCCCCCCCCC		31.1322369663
80PhosphorylationESDHGRMSPVLTTPK
CCCCCCCCCCCCCCC		15.5322369663
84PhosphorylationGRMSPVLTTPKRHAP
CCCCCCCCCCCCCCC		41.0922369663
85PhosphorylationRMSPVLTTPKRHAPP
CCCCCCCCCCCCCCC		23.7422369663
100PhosphorylationPEQLQNVTDFNYTPS
HHHHCCCCCCCCCCC		42.2824961812
104PhosphorylationQNVTDFNYTPSHQKP
CCCCCCCCCCCCCCC		21.7428889911
105PhosphorylationNVTDFNYTPSHQKPF
CCCCCCCCCCCCCCC		21.3028889911
107PhosphorylationTDFNYTPSHQKPFLQ
CCCCCCCCCCCCCCC		30.6524961812
119PhosphorylationFLQPQAGTTVTTHQD
CCCCCCCCEEECHHH		22.5519779198
120PhosphorylationLQPQAGTTVTTHQDI
CCCCCCCEEECHHHH		18.2221440633
137PhosphorylationIVEMTLGSEGVLNQA
HHHHHHCCCCHHCHH		34.0028889911
229PhosphorylationQDQFDDESLFPSKVT
HHHCCCCCCCCCCCC		42.1628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MOB1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MOB1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MOB1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DBF2_YEASTDBF2physical
9528782
POP2_YEASTPOP2physical
9528782
MPS1_YEASTMPS1physical
9436989
AMN1_YEASTAMN1genetic
12628189
DBF2_YEASTDBF2genetic
9528782
SIC1_YEASTSIC1genetic
11564880
CDC15_YEASTCDC15genetic
9436989
CDC5_YEASTCDC5genetic
9436989
LTE1_YEASTLTE1genetic
9436989
NET1_YEASTNET1genetic
11914130
2ABA_YEASTCDC55genetic
16079183
PP2A1_YEASTPPH21genetic
16079183
PP2A2_YEASTPPH22genetic
16079183
CBF3A_YEASTCBF2physical
16176976
IPL1_YEASTIPL1physical
16176976
SLI15_YEASTSLI15physical
16176976
BIR1_YEASTBIR1physical
16176976
MOB1_YEASTMOB1physical
16934835
MOB2_YEASTMOB2physical
16934835
MTC4_YEASTMTC4physical
11283351
CBK1_YEASTCBK1physical
11283351
TOF2_YEASTTOF2genetic
18923139
CYK3_YEASTCYK3genetic
20093466
BRE1_YEASTBRE1genetic
20093466
PEX19_YEASTPEX19genetic
20093466
CAJ1_YEASTCAJ1genetic
20093466
RTF1_YEASTRTF1genetic
20093466
MED5_YEASTNUT1genetic
20093466
PEF1_YEASTPEF1genetic
20093466
NST1_YEASTNST1genetic
20093466
MED9_YEASTCSE2genetic
20093466
MNE1_YEASTMNE1genetic
20093466
SLT2_YEASTSLT2genetic
20489023
BCK1_YEASTBCK1genetic
20489023
ARO1_YEASTARO1physical
20489023
ATPG_YEASTATP3physical
20489023
DBP5_YEASTDBP5physical
20489023
DHH1_YEASTDHH1physical
20489023
DSK2_YEASTDSK2physical
20489023
EBS1_YEASTEBS1physical
20489023
GCN1_YEASTGCN1physical
20489023
HRP1_YEASTHRP1physical
20489023
MIG3_YEASTMIG3physical
20489023
MPM1_YEASTMPM1physical
20489023
PBP4_YEASTPBP4physical
20489023
PFKA1_YEASTPFK1physical
20489023
QCR2_YEASTQCR2physical
20489023
EIF3A_YEASTRPG1physical
20489023
RV167_YEASTRVS167physical
20489023
METK1_YEASTSAM1physical
20489023
SEC16_YEASTSEC16physical
20489023
COPB_YEASTSEC26physical
20489023
TAF6_YEASTTAF6physical
20489023
VATC_YEASTVMA5physical
20489023
YPK1_YEASTYPK1physical
20489023
CYK2_YEASTHOF1physical
21498574
DBF2_YEASTDBF2physical
22718910
DBF20_YEASTDBF20physical
22718910
DBF2_YEASTDBF2physical
19221193
DBF2_YEASTDBF2physical
21498574
BFA1_YEASTBFA1genetic
25658911
NET1_YEASTNET1genetic
26090959
2ABA_YEASTCDC55genetic
26090959
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MOB1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-36; THR-38;SER-80; THR-85 AND SER-137, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND THR-85, AND MASSSPECTROMETRY.

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