PP2A2_YEAST - dbPTM
PP2A2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2A2_YEAST
UniProt AC P23595
Protein Name Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
Gene Name PPH22
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 377
Subcellular Localization
Protein Description Exact function not known, phosphatase 2A performs an essential cellular function..
Protein Sequence MDMEIDDPMHGSDEDQLSPTLDEDMNSDDGKNNTKARSNDEDTDEELEDFNFKPGSSGIADHKSSKPLKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRPGEPTVTRKTPDYFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationIDDPMHGSDEDQLSP
CCCCCCCCCHHHCCC		24.1328152593
18PhosphorylationGSDEDQLSPTLDEDM
CCCHHHCCCCCCCCC		15.3728152593
27PhosphorylationTLDEDMNSDDGKNNT
CCCCCCCCCCCCCCC		30.3728889911
38PhosphorylationKNNTKARSNDEDTDE
CCCCCCCCCCCCCHH		54.1922369663
43PhosphorylationARSNDEDTDEELEDF
CCCCCCCCHHHHHHC		43.1722369663
53AcetylationELEDFNFKPGSSGIA
HHHHCCCCCCCCCCC		49.9624489116
56PhosphorylationDFNFKPGSSGIADHK
HCCCCCCCCCCCCCC		33.6417563356
57PhosphorylationFNFKPGSSGIADHKS
CCCCCCCCCCCCCCC		39.8829136822
64PhosphorylationSGIADHKSSKPLKLT
CCCCCCCCCCCCCCC		39.9325704821
73PhosphorylationKPLKLTNTNINQLDQ
CCCCCCCCCHHHHHH		32.0421440633
239PhosphorylationFCLHGGLSPMIETID
EEECCCCHHHHHHHH		18.7228889911
280PhosphorylationDRGGWGISPRGAGFT
CCCCCCCCCCCCCCC		12.4722369663
371UbiquitinationGEPTVTRKTPDYFL-
CCCCCCCCCCCCCC-		55.8523749301
372PhosphorylationEPTVTRKTPDYFL--
CCCCCCCCCCCCC--		20.3627214570
377MethylationRKTPDYFL-------
CCCCCCCC-------		5.8111060018
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP2A2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2A2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2A2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HMCS_YEASTERG13physical
11805826
PSB4_YEASTPRE1physical
11805826
PSA7_YEASTPRE10physical
11805826
PSB5_YEASTPRE2physical
11805826
PSB7_YEASTPRE4physical
11805826
PSA6_YEASTPRE5physical
11805826
PSA4_YEASTPRE6physical
11805826
PSB6_YEASTPRE7physical
11805826
PSA2_YEASTPRE8physical
11805826
PSA3_YEASTPRE9physical
11805826
PSB2_YEASTPUP1physical
11805826
PSA5_YEASTPUP2physical
11805826
PSB3_YEASTPUP3physical
11805826
PSA1_YEASTSCL1physical
11805826
G3P2_YEASTTDH2physical
11805826
2ABA_YEASTCDC55physical
11805837
RTS3_YEASTRTS3physical
11805837
PPME1_YEASTPPE1physical
11805837
2A5D_YEASTRTS1physical
11805837
RUVB1_YEASTRVB1physical
11805837
MKT1_YEASTMKT1physical
11805837
RPA2_YEASTRPA135physical
11805837
2AAA_YEASTTPD3physical
11805837
GPG1_YEASTGPG1physical
11805837
RPB11_YEASTRPB11physical
11805837
TAP42_YEASTTAP42physical
11805837
H2A2_YEASTHTA2physical
11805837
2ABA_YEASTCDC55physical
10329624
TAP42_YEASTTAP42physical
10329624
2AAA_YEASTTPD3physical
10329624
2AAA_YEASTTPD3physical
11060018
2ABA_YEASTCDC55physical
11060018
TAP42_YEASTTAP42physical
11060018
2ABA_YEASTCDC55physical
11129046
2AAA_YEASTTPD3physical
11129046
PP2A1_YEASTPPH21genetic
11967829
PP2A1_YEASTPPH21genetic
7744031
SCH9_YEASTSCH9genetic
11401708
SSD1_YEASTSSD1genetic
9071579
PAM1_YEASTPAM1genetic
8106383
2ABA_YEASTCDC55genetic
11129046
2ABA_YEASTCDC55physical
16554755
T2EA_YEASTTFA1physical
16554755
T2EB_YEASTTFA2physical
16554755
ZDS1_YEASTZDS1physical
16554755
HSP7F_YEASTSSE1physical
16429126
G3P2_YEASTTDH2physical
16429126
PTPA2_YEASTRRD2physical
12952889
CDC5_YEASTCDC5genetic
18493323
PP4C_YEASTPPH3genetic
18316413
PP2A1_YEASTPPH21genetic
18316413
PP2A1_YEASTPPH21genetic
19269370
PTP1_YEASTPTP1genetic
19269370
STE20_YEASTSTE20genetic
19269370
YAK1_YEASTYAK1genetic
19269370
KKQ8_YEASTKKQ8genetic
19269370
TDA1_YEASTTDA1genetic
19269370
SSB2_YEASTSSB2physical
19536198
RTS3_YEASTRTS3physical
20489023
RUVB2_YEASTRVB2physical
20489023
SCJ1_YEASTSCJ1physical
20489023
TAP42_YEASTTAP42physical
20489023
PP2C1_YEASTPTC1genetic
21127252
PP2A1_YEASTPPH21genetic
21127252
RTG3_YEASTRTG3genetic
21127252
2A5D_YEASTRTS1genetic
22290422
PP4C_YEASTPPH3genetic
7796803
MPIP_YEASTMIH1genetic
7796803
CDK1_YEASTCDC28genetic
7796803
APC1_YEASTAPC1physical
23751495
CDC16_YEASTCDC16physical
23751495
CDC27_YEASTCDC27physical
23751495
APC9_YEASTAPC9physical
23751495
MPIP_YEASTMIH1physical
18316413
SCC1_YEASTMCD1physical
22814605
SWE1_YEASTSWE1physical
21849476
VBA3_YEASTVBA3genetic
27708008
VMS1_YEASTVMS1genetic
27708008
SAC3_YEASTSAC3genetic
27708008
INM2_YEASTINM2genetic
27708008
SHE9_YEASTSHE9genetic
27708008
ATC1_YEASTPMR1genetic
27708008
MTC3_YEASTMTC3genetic
27708008
YPS6_YEASTYPS6genetic
27708008
GSH1_YEASTGSH1genetic
27708008
CBF1_YEASTCBF1genetic
27708008
MNS1_YEASTMNS1genetic
27708008
TVP38_YEASTTVP38genetic
27708008
ARV1_YEASTARV1genetic
27708008
TSA1_YEASTTSA1genetic
27708008
RCF1_YEASTRCF1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
KAR3_YEASTKAR3genetic
27708008
DCAM_YEASTSPE2genetic
27453043
CYPB_YEASTCPR2genetic
27453043
PGTB2_YEASTBET2genetic
27453043
CDC42_YEASTCDC42genetic
27453043
IRA2_YEASTIRA2genetic
27453043
SIP2_YEASTSIP2genetic
27453043
VPS15_YEASTVPS15genetic
27453043
DCOR_YEASTSPE1genetic
27453043
DBF2_YEASTDBF2genetic
27453043
SWI6_YEASTSWI6genetic
27453043
CDC13_YEASTCDC13physical
25387524
CDC13_YEASTCDC13genetic
25387524
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2A2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-43 AND SER-56, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-43, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-43, AND MASSSPECTROMETRY.

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