MPIP_YEAST - dbPTM
MPIP_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPIP_YEAST
UniProt AC P23748
Protein Name M-phase inducer phosphatase
Gene Name MIH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 554
Subcellular Localization
Protein Description Terminates the cell cycle delay. Reverses the CDC28 phosphorylation catalyzed by SWE1..
Protein Sequence MNNIFHGTEDECANEDVLSFQKISLKSPFGKKKNIFRNVQTFFKSKSKHSNVDDDLINKENLAFDKSPLLTNHRSKEIDGPSPNIKQLGHRDELDENENENDDIVLSMHFASQTLQSPTRNSSRRSLTNNRDNDLLSRIKYPGSPQRSSSFSRSRSLSRKPSMNSSSNSSRRVQRQDGKIPRSSRKSSQKFSNITQNTLNFTSASSSPLAPNSVGVKCFESCLAKTQIPYYYDDRNSNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEYTGGHIINSVNIHSRDELEYEFIHKVLHSDTSNNNTLPTLLIIHCEFSSHRGPSLASHLRNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGMNSQENLLNCEQEMDKFRRESKRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLSLNHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSFEDERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26AcetylationSFQKISLKSPFGKKK
CEEEEECCCCCCCCC		49.6622865919
27PhosphorylationFQKISLKSPFGKKKN
EEEEECCCCCCCCCH		30.6521440633
75PhosphorylationPLLTNHRSKEIDGPS
CCHHCCCCCCCCCCC		27.3921440633
82PhosphorylationSKEIDGPSPNIKQLG
CCCCCCCCCCHHHCC		35.7928152593
126PhosphorylationTRNSSRRSLTNNRDN
CCCCCCHHCCCCCCC		38.1322369663
128PhosphorylationNSSRRSLTNNRDNDL
CCCCHHCCCCCCCCH		31.5222369663
144PhosphorylationSRIKYPGSPQRSSSF
HHCCCCCCCCCCCCC		17.2321440633
150PhosphorylationGSPQRSSSFSRSRSL
CCCCCCCCCCCCCCC		28.6121440633
162PhosphorylationRSLSRKPSMNSSSNS
CCCCCCCCCCCCCCH		33.3630377154
165PhosphorylationSRKPSMNSSSNSSRR
CCCCCCCCCCCHHHH		26.8830377154
166PhosphorylationRKPSMNSSSNSSRRV
CCCCCCCCCCHHHHH		28.6530377154
167PhosphorylationKPSMNSSSNSSRRVQ
CCCCCCCCCHHHHHH		40.3230377154
169PhosphorylationSMNSSSNSSRRVQRQ
CCCCCCCHHHHHHHH		27.4630377154
203PhosphorylationQNTLNFTSASSSPLA
HHCCCCCCCCCCCCC		23.2421440633
205PhosphorylationTLNFTSASSSPLAPN
CCCCCCCCCCCCCCC		30.9921440633
206PhosphorylationLNFTSASSSPLAPNS
CCCCCCCCCCCCCCC		35.3721440633
207PhosphorylationNFTSASSSPLAPNSV
CCCCCCCCCCCCCCC		22.8021440633
348UbiquitinationINQDHYPKLFYPDIL
CCCCCCCHHHCCCEE		44.0217644757
362UbiquitinationLILDGGYKAVFDNFP
EEECCCHHHHHCCCH		41.1517644757
377PhosphorylationELCYPRQYVGMNSQE
HHCCCHHHCCCCCHH		10.5528889911
382PhosphorylationRQYVGMNSQENLLNC
HHHCCCCCHHHHHCH		29.9420377248
406UbiquitinationESKRFATKNNSFRKL
HHHHHHCCCCHHHHC		51.1823749301
409PhosphorylationRFATKNNSFRKLASP
HHHCCCCHHHHCCCC		35.5023749301
412UbiquitinationTKNNSFRKLASPSNP
CCCCHHHHCCCCCCC		46.5223749301
415PhosphorylationNSFRKLASPSNPNFF
CHHHHCCCCCCCCCC		39.0229136822
417PhosphorylationFRKLASPSNPNFFYR
HHHCCCCCCCCCCCC		63.5224930733
429PhosphorylationFYRDSHQSSTTMASS
CCCCCCCCCCCCCCC		24.9928889911
457PhosphorylationLNHRRVSSGSSLNSS
CCCCCCCCCCCCCCC		39.5819779198
459PhosphorylationHRRVSSGSSLNSSES
CCCCCCCCCCCCCCC		33.3328889911
464PhosphorylationSGSSLNSSESTGDEN
CCCCCCCCCCCCCCC		34.2028889911
466PhosphorylationSSLNSSESTGDENFF
CCCCCCCCCCCCCCH		39.3728889911
517PhosphorylationRGNHQQVSGDEEQDG
CCCCCCCCCCCCCCC		35.8728889911
531PhosphorylationGDFTFVGSDREDLPR
CCEEEECCCHHHCCC		28.3528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPIP_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPIP_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPIP_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2B2_YEASTHTB2physical
11805837
CYPH_YEASTCPR1physical
11805837
QCR2_YEASTQCR2physical
11805837
QCR1_YEASTCOR1physical
11805837
HSL1_YEASTHSL1genetic
17314980
SEC22_YEASTSEC22genetic
17314980
EAF1_YEASTEAF1genetic
17314980
CDC6_YEASTCDC6genetic
17130241
SWE1_YEASTSWE1genetic
18316413
SEC22_YEASTSEC22genetic
19269370
HSL1_YEASTHSL1genetic
19211841
HSL1_YEASTHSL1genetic
18768748
HSL7_YEASTHSL7genetic
18768748
ELM1_YEASTELM1genetic
18768748
NDD1_YEASTNDD1genetic
18768748
CSK22_YEASTCKA2physical
20489023
HRR25_YEASTHRR25physical
20489023
KEL1_YEASTKEL1physical
20489023
KIN2_YEASTKIN2physical
20489023
MAM33_YEASTMAM33physical
20489023
RPM2_YEASTRPM2physical
20489023
SLH1_YEASTSLH1physical
20489023
TOR2_YEASTTOR2physical
20489023
ZDS1_YEASTZDS1genetic
20980617
ZDS2_YEASTZDS2genetic
20980617
SWE1_YEASTSWE1genetic
21562220
HSL1_YEASTHSL1genetic
21127252
ELM1_YEASTELM1genetic
21127252
CHA4_YEASTCHA4genetic
21127252
SWE1_YEASTSWE1genetic
8253069
CDK1_YEASTCDC28genetic
7796803
SWE1_YEASTSWE1genetic
12388757
CDC20_YEASTCDC20genetic
23751495
CDH1_YEASTCDH1genetic
23751495
SWE1_YEASTSWE1genetic
23751495
SHG1_YEASTSHG1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
STE50_YEASTSTE50genetic
27708008
ATC4_YEASTDNF2genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
MNN10_YEASTMNN10genetic
27708008
EF2_YEASTEFT2genetic
27708008
UBP6_YEASTUBP6genetic
27708008
HUR1_YEASTHUR1genetic
27708008
TNA1_YEASTTNA1genetic
27708008
ALLA_YEASTDAL3genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
ELM1_YEASTELM1genetic
27708008
HSL1_YEASTHSL1genetic
27708008
PDC1_YEASTPDC1genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
SCJ1_YEASTSCJ1genetic
27708008
OCA1_YEASTOCA1genetic
27708008
2A5D_YEASTRTS1genetic
27708008
SFL1_YEASTSFL1genetic
27708008
HSL1_YEASTHSL1genetic
27193302
PEP8_YEASTPEP8physical
28362258
PTP1_YEASTPTP1genetic
26715668
2A5D_YEASTRTS1genetic
26715668
CDK1_YEASTCDC28physical
26715668
SLA1_YEASTSLA1genetic
29674565
EDE1_YEASTEDE1genetic
29674565
TCPA_YEASTTCP1genetic
29674565
YEW0_YEASTCOM2genetic
29674565
SIN3_YEASTSIN3genetic
29674565
KRE5_YEASTKRE5genetic
29674565
DAD1_YEASTDAD1genetic
29674565
UME6_YEASTUME6genetic
29674565
MAS5_YEASTYDJ1genetic
29674565
SEC23_YEASTSEC23genetic
29674565
CDC27_YEASTCDC27genetic
29674565
CSG2_YEASTCSG2genetic
29674565
CKS1_YEASTCKS1genetic
29674565
APC11_YEASTAPC11genetic
29674565
GDI1_YEASTGDI1genetic
29674565
CAK1_YEASTCAK1genetic
29674565
HUR1_YEASTHUR1genetic
29674565
CDC11_YEASTCDC11genetic
29674565
YJ9I_YEASTYJR141Wgenetic
29674565
HSL1_YEASTHSL1genetic
29674565
PRS7_YEASTRPT1genetic
29674565
SSL1_YEASTSSL1genetic
29674565
GAS1_YEASTGAS1genetic
29674565
NST1_YEASTNST1genetic
29674565
NOP12_YEASTNOP12genetic
29674565
2A5D_YEASTRTS1genetic
29674565
APC5_YEASTAPC5genetic
29674565
COG3_YEASTCOG3genetic
29674565
KEX1_YEASTKEX1genetic
29674565
PEP8_YEASTPEP8genetic
29674565
HXT8_YEASTHXT8genetic
29674565
CSF1_YEASTCSF1genetic
29674565
VPS38_YEASTVPS38genetic
29674565
ZDS1_YEASTZDS1genetic
29674565
GLO4_YEASTGLO4genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPIP_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND SER-417, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-417, AND MASSSPECTROMETRY.

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