| UniProt ID | KIN2_YEAST | |
|---|---|---|
| UniProt AC | P13186 | |
| Protein Name | Serine/threonine-protein kinase KIN2 | |
| Gene Name | KIN2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1147 | |
| Subcellular Localization |
Cytoplasm. Cell membrane Peripheral membrane protein Cytoplasmic side. |
|
| Protein Description | Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.. | |
| Protein Sequence | MPNPNTADYLVNPNFRTSKGGSLSPTPEAFNDTRVAAPATLRMMGKQSGPRNDQQQAPLMPPADIKQGKEQAAQRQNDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYDFKAPSYVPNRVPLTPEMIDSQVLKEMYRLEFIDDIEDTRRSLIRLVTEKEYIQLSQEYWDKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLLSIYHLVSEMVARKLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNNNSPDIMTKMRSPQKEVVPNPGIFQVPAIGTSGTSNNTNTSNKPPLHVMVPPKLTIPEQAHTSPTSRKSSDIHTELNGVLKSTPVPVSGEYQQRSASPVVGEHQEKNTIGGIFRRISQSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHSRTISDYIPSARRYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKLQINDNDNNNVNAVVDGINNDNSDHYLSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPAALPPSDMTNDNGFLGEANKERYNPVSSNFSTVPEDSTTYSNDTNNRLTSVYSQELTEKQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKEVKGGFICVQQRPSIETAAVPVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSASRNSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNGTSGELSSMSLDYVQQQDDILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGLAGVHFKKVSGNTWLYKELASYILKELNL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MPNPNTADYLVNP --CCCCCCCCCCCCC | 23.35 | 27214570 | |
| 9 | Phosphorylation | PNPNTADYLVNPNFR CCCCCCCCCCCCCCC | 15.30 | 19795423 | |
| 17 | Phosphorylation | LVNPNFRTSKGGSLS CCCCCCCCCCCCCCC | 30.56 | 22369663 | |
| 18 | Phosphorylation | VNPNFRTSKGGSLSP CCCCCCCCCCCCCCC | 25.66 | 22369663 | |
| 22 | Phosphorylation | FRTSKGGSLSPTPEA CCCCCCCCCCCCHHH | 34.05 | 21082442 | |
| 24 | Phosphorylation | TSKGGSLSPTPEAFN CCCCCCCCCCHHHHC | 28.55 | 25533186 | |
| 26 | Phosphorylation | KGGSLSPTPEAFNDT CCCCCCCCHHHHCCC | 30.31 | 29136822 | |
| 33 | Phosphorylation | TPEAFNDTRVAAPAT CHHHHCCCCCCCHHH | 28.31 | 29136822 | |
| 95 | Phosphorylation | LRQFHRRSLGDWEFL HHHHHHHCCCCHHHH | 36.34 | 30377154 | |
| 143 | Phosphorylation | AYLHKQHSLPSPKNE HHHHHHCCCCCCCCH | 39.21 | 29688323 | |
| 146 | Phosphorylation | HKQHSLPSPKNESEI HHHCCCCCCCCHHHH | 54.52 | 25521595 | |
| 151 | Phosphorylation | LPSPKNESEILERQK CCCCCCHHHHHHHHH | 39.05 | 22369663 | |
| 257 | Phosphorylation | KIENIMISSSGEIKI CEECEEECCCCCEEE | 10.89 | 21551504 | |
| 259 | Phosphorylation | ENIMISSSGEIKIID ECEEECCCCCEEEEE | 33.38 | 21551504 | |
| 281 | Phosphorylation | DYRKQLHTFCGSLYF HHHHHHHHHHHHHHH | 29.25 | 22369663 | |
| 285 | Phosphorylation | QLHTFCGSLYFAAPE HHHHHHHHHHHCCHH | 22.52 | 21440633 | |
| 287 | Phosphorylation | HTFCGSLYFAAPELL HHHHHHHHHCCHHHH | 7.89 | 22369663 | |
| 396 | Phosphorylation | VPNRVPLTPEMIDSQ CCCCCCCCHHHCCHH | 15.90 | 19779198 | |
| 549 | Phosphorylation | KVALNNNSPDIMTKM HHHCCCCCCCHHHHC | 26.52 | 25521595 | |
| 601 | Phosphorylation | VMVPPKLTIPEQAHT EECCCCCCCCCCCCC | 40.38 | 28132839 | |
| 608 | Phosphorylation | TIPEQAHTSPTSRKS CCCCCCCCCCCCCCC | 39.14 | 24909858 | |
| 609 | Phosphorylation | IPEQAHTSPTSRKSS CCCCCCCCCCCCCCC | 19.13 | 25521595 | |
| 611 | Phosphorylation | EQAHTSPTSRKSSDI CCCCCCCCCCCCCCC | 40.71 | 19823750 | |
| 612 | Phosphorylation | QAHTSPTSRKSSDIH CCCCCCCCCCCCCCC | 40.89 | 25521595 | |
| 615 | Phosphorylation | TSPTSRKSSDIHTEL CCCCCCCCCCCCHHH | 31.94 | 22369663 | |
| 616 | Phosphorylation | SPTSRKSSDIHTELN CCCCCCCCCCCHHHC | 43.55 | 22369663 | |
| 628 | Phosphorylation | ELNGVLKSTPVPVSG HHCCEECCCCCCCCC | 33.51 | 28889911 | |
| 634 | Phosphorylation | KSTPVPVSGEYQQRS CCCCCCCCCCCCCCC | 21.60 | 28889911 | |
| 637 | Phosphorylation | PVPVSGEYQQRSASP CCCCCCCCCCCCCCC | 17.30 | 21440633 | |
| 641 | Phosphorylation | SGEYQQRSASPVVGE CCCCCCCCCCCCCCC | 28.85 | 25521595 | |
| 643 | Phosphorylation | EYQQRSASPVVGEHQ CCCCCCCCCCCCCCC | 21.34 | 22369663 | |
| 654 | Phosphorylation | GEHQEKNTIGGIFRR CCCCCCCCHHHHHHH | 31.87 | 24961812 | |
| 663 | Phosphorylation | GGIFRRISQSGQSQH HHHHHHHHCCCCCCC | 19.24 | 25533186 | |
| 665 | Phosphorylation | IFRRISQSGQSQHPT HHHHHHCCCCCCCCC | 31.82 | 22890988 | |
| 668 | Phosphorylation | RISQSGQSQHPTRQQ HHHCCCCCCCCCCCC | 33.70 | 24961812 | |
| 672 | Phosphorylation | SGQSQHPTRQQEPLP CCCCCCCCCCCCCCC | 38.70 | 24961812 | |
| 700 | Phosphorylation | ISIKVPKSHSRTISD EEEECCCCCCCCHHH | 22.18 | 24961812 | |
| 702 | Phosphorylation | IKVPKSHSRTISDYI EECCCCCCCCHHHHC | 37.90 | 24961812 | |
| 704 | Phosphorylation | VPKSHSRTISDYIPS CCCCCCCCHHHHCCH | 28.04 | 28132839 | |
| 706 | Phosphorylation | KSHSRTISDYIPSAR CCCCCCHHHHCCHHH | 24.61 | 24909858 | |
| 708 | Phosphorylation | HSRTISDYIPSARRY CCCCHHHHCCHHHCC | 14.13 | 28889911 | |
| 711 | Phosphorylation | TISDYIPSARRYPSY CHHHHCCHHHCCCCC | 25.50 | 28889911 | |
| 717 | Phosphorylation | PSARRYPSYVPNSVD CHHHCCCCCCCCCCC | 29.81 | 24961812 | |
| 734 | Phosphorylation | QKPAKNTTIAPPIRS CCCCCCCCCCCCCCC | 25.24 | 24961812 | |
| 741 | Phosphorylation | TIAPPIRSVSQKQNS CCCCCCCCHHHHCCC | 27.17 | 23749301 | |
| 743 | Phosphorylation | APPIRSVSQKQNSDL CCCCCCHHHHCCCCC | 32.67 | 17330950 | |
| 748 | Phosphorylation | SVSQKQNSDLPALPQ CHHHHCCCCCCCCCC | 37.72 | 21440633 | |
| 798 | Phosphorylation | DGINNDNSDHYLSVP ECCCCCCCCCCEECC | 28.73 | 20377248 | |
| 801 | Phosphorylation | NNDNSDHYLSVPKGR CCCCCCCCEECCCCC | 12.98 | 21440633 | |
| 818 | Phosphorylation | HPSARAKSVGHARRE CHHHHHHCCHHHHHH | 32.14 | 17287358 | |
| 826 | Phosphorylation | VGHARRESLKFTRPP CHHHHHHHCCCCCCC | 34.74 | 17287358 | |
| 841 | Phosphorylation | IPAALPPSDMTNDNG CCCCCCCHHCCCCCC | 37.77 | 28889911 | |
| 844 | Phosphorylation | ALPPSDMTNDNGFLG CCCCHHCCCCCCCCC | 44.40 | 28889911 | |
| 874 | Phosphorylation | TVPEDSTTYSNDTNN CCCCCCCCCCCCCCC | 28.98 | 28889911 | |
| 876 | Phosphorylation | PEDSTTYSNDTNNRL CCCCCCCCCCCCCCC | 26.57 | 28889911 | |
| 884 | Phosphorylation | NDTNNRLTSVYSQEL CCCCCCCHHHHCHHC | 16.95 | 21126336 | |
| 885 | Phosphorylation | DTNNRLTSVYSQELT CCCCCCHHHHCHHCC | 24.53 | 28889911 | |
| 887 | Phosphorylation | NNRLTSVYSQELTEK CCCCHHHHCHHCCHH | 12.38 | 27017623 | |
| 888 | Phosphorylation | NRLTSVYSQELTEKQ CCCHHHHCHHCCHHH | 18.28 | 17330950 | |
| 892 | Phosphorylation | SVYSQELTEKQILEE HHHCHHCCHHHHHHH | 40.14 | 21440633 | |
| 993 | Phosphorylation | KAMDLQNSLDSQLSS CCHHHHHHHHHHHHH | 22.16 | 28889911 | |
| 996 | Phosphorylation | DLQNSLDSQLSSSYH HHHHHHHHHHHHHHH | 38.01 | 28889911 | |
| 999 | Phosphorylation | NSLDSQLSSSYHSTA HHHHHHHHHHHHHCC | 15.03 | 21551504 | |
| 1000 | Phosphorylation | SLDSQLSSSYHSTAS HHHHHHHHHHHHCCC | 43.43 | 21440633 | |
| 1002 | Phosphorylation | DSQLSSSYHSTASSA HHHHHHHHHHCCCHH | 11.18 | 19779198 | |
| 1004 | Phosphorylation | QLSSSYHSTASSASR HHHHHHHHCCCHHHC | 19.89 | 21440633 | |
| 1007 | Phosphorylation | SSYHSTASSASRNSS HHHHHCCCHHHCCCH | 26.90 | 19779198 | |
| 1008 | Phosphorylation | SYHSTASSASRNSSI HHHHCCCHHHCCCHH | 28.00 | 19779198 | |
| 1010 | Phosphorylation | HSTASSASRNSSIKR HHCCCHHHCCCHHHC | 33.66 | 21440633 | |
| 1014 | Phosphorylation | SSASRNSSIKRQGSY CHHHCCCHHHCCCCC | 35.36 | 21440633 | |
| 1021 | Phosphorylation | SIKRQGSYKRGQNNI HHHCCCCCCCCCCCC | 16.13 | 21440633 | |
| 1031 | Phosphorylation | GQNNIPLTPLATNTH CCCCCCCCCCCCCCC | 15.76 | 21082442 | |
| 1037 | Phosphorylation | LTPLATNTHQRNSSI CCCCCCCCCCCCCCC | 18.28 | 28889911 | |
| 1097 | Phosphorylation | QTEQTNTSGIKERPP CCCCCCCCCCCCCCC | 40.36 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KIN2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KIN2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KIN2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; SER-151; SER-549;SER-609; SER-612; SER-641; SER-643; SER-663 AND SER-888, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146; SER-641; SER-643AND SER-665, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND THR-611, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549; SER-609 ANDSER-888, AND MASS SPECTROMETRY. | |
