| UniProt ID | UBP10_YEAST | |
|---|---|---|
| UniProt AC | P53874 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 10 | |
| Gene Name | UBP10 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 792 | |
| Subcellular Localization | Nucleus . Chromosome, telomere . Nucleus, nucleolus . Preferentially localizes to silent chromatin (PubMed:15988024). | |
| Protein Description | Deubiquitinating enzyme involved in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. [PubMed: 9755194] | |
| Protein Sequence | MTTQESIKPLVDRILSNPLQFNAAMISNKSNNNDTSAAPENSSYIVIGKQHNNNSNSTAIAATAESKQIKENNLIDRPNGKKTNTVPKSMAEALLLYTSKNDKDAADATGAKKSAELSTELSTEPPSSSSEDDKVGKEEEEEGEIFHEARDYVEPRKASLKERDNADKGDGEDIGEDIGEDIGEDIGEDIGEDIGENLGSPLATIDDSSNENEKEKRKELSTSISSDDEIEDDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLMENSTVEVNRYEPVNNTKENGNRNPKGEEEEEEEEELKHKSRSITPPVTISNLSNFYQFNENINDRGSLNSTRIVKNWGDKFTNLKPRGLLNHGVTCYTNAAVQAMLHIPSIQHYLFDILMGKYDSTISKNSVSYTLAETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCMMSEWQQEDSHEYFMSLMSRLQEDSVPKGHKLIESIIYDIFGGLLKQIVTCKSCGSISKTEQPFYDLSLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLNNGSPFAAASDLSSANRRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFNGTSSSKMKQAVSYPMFLDLTEYCESKELPVKYQLLSVVVHEGRSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPLPLAKSAMATGNVTSKSKQEQAVNEPNNRPLKINSKKNNRKKWKKNKKRKFTK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MTTQESIKPL -----CCCHHHHHHH | 29.10 | 30377154 | |
| 112 | Acetylation | AADATGAKKSAELST HHHHHCCHHHHHHHH | 48.91 | 25381059 | |
| 114 | Phosphorylation | DATGAKKSAELSTEL HHHCCHHHHHHHHCC | 26.69 | 19795423 | |
| 119 | Phosphorylation | KKSAELSTELSTEPP HHHHHHHHCCCCCCC | 54.28 | 19795423 | |
| 122 | Phosphorylation | AELSTELSTEPPSSS HHHHHCCCCCCCCCC | 25.21 | 19795423 | |
| 123 | Phosphorylation | ELSTELSTEPPSSSS HHHHCCCCCCCCCCC | 66.20 | 19795423 | |
| 127 | Phosphorylation | ELSTEPPSSSSEDDK CCCCCCCCCCCCCCC | 54.27 | 19795423 | |
| 128 | Phosphorylation | LSTEPPSSSSEDDKV CCCCCCCCCCCCCCC | 43.59 | 19795423 | |
| 129 | Phosphorylation | STEPPSSSSEDDKVG CCCCCCCCCCCCCCC | 41.92 | 19795423 | |
| 130 | Phosphorylation | TEPPSSSSEDDKVGK CCCCCCCCCCCCCCC | 47.17 | 19795423 | |
| 200 | Phosphorylation | DIGENLGSPLATIDD HHHHHCCCCCCCCCC | 21.65 | 19795423 | |
| 204 | Phosphorylation | NLGSPLATIDDSSNE HCCCCCCCCCCCCCC | 32.40 | 19823750 | |
| 208 | Phosphorylation | PLATIDDSSNENEKE CCCCCCCCCCCCHHH | 31.17 | 19823750 | |
| 209 | Phosphorylation | LATIDDSSNENEKEK CCCCCCCCCCCHHHH | 55.98 | 19823750 | |
| 258 | Phosphorylation | PEEEENDSSSKISEG CHHHCCCCCCCCCHH | 48.36 | 29136822 | |
| 259 | Phosphorylation | EEEENDSSSKISEGE HHHCCCCCCCCCHHH | 38.21 | 29136822 | |
| 260 | Phosphorylation | EEENDSSSKISEGEK HHCCCCCCCCCHHHH | 37.65 | 29136822 | |
| 263 | Phosphorylation | NDSSSKISEGEKKSL CCCCCCCCHHHHHHH | 43.20 | 19823750 | |
| 271 | Phosphorylation | EGEKKSLYQDLMENS HHHHHHHHHHHHHCC | 13.68 | 27017623 | |
| 278 | Phosphorylation | YQDLMENSTVEVNRY HHHHHHCCCEEEEEE | 22.11 | 28889911 | |
| 279 | Phosphorylation | QDLMENSTVEVNRYE HHHHHCCCEEEEEEE | 32.06 | 21440633 | |
| 315 | Phosphorylation | EEELKHKSRSITPPV HHHHHHHCCCCCCCE | 30.86 | 19779198 | |
| 317 | Phosphorylation | ELKHKSRSITPPVTI HHHHHCCCCCCCEEH | 37.59 | 28889911 | |
| 319 | Phosphorylation | KHKSRSITPPVTISN HHHCCCCCCCEEHHH | 23.84 | 21440633 | |
| 325 | Phosphorylation | ITPPVTISNLSNFYQ CCCCEEHHHCCHHHC | 23.50 | 21440633 | |
| 328 | Phosphorylation | PVTISNLSNFYQFNE CEEHHHCCHHHCCCC | 29.19 | 30377154 | |
| 355 | Acetylation | IVKNWGDKFTNLKPR EECCCCCCCCCCCCC | 50.58 | 24489116 | |
| 360 | Acetylation | GDKFTNLKPRGLLNH CCCCCCCCCCCCCCC | 34.44 | 24489116 | |
| 398 | Phosphorylation | FDILMGKYDSTISKN HHHHCCCCCCCCCCC | 14.92 | 30377154 | |
| 400 | Phosphorylation | ILMGKYDSTISKNSV HHCCCCCCCCCCCCC | 25.26 | 30377154 | |
| 401 | Phosphorylation | LMGKYDSTISKNSVS HCCCCCCCCCCCCCC | 26.77 | 30377154 | |
| 403 | Phosphorylation | GKYDSTISKNSVSYT CCCCCCCCCCCCCEE | 26.35 | 30377154 | |
| 406 | Phosphorylation | DSTISKNSVSYTLAE CCCCCCCCCCEEEEE | 19.04 | 30377154 | |
| 408 | Phosphorylation | TISKNSVSYTLAETS CCCCCCCCEEEEECC | 16.54 | 30377154 | |
| 409 | Phosphorylation | ISKNSVSYTLAETSK CCCCCCCEEEEECCC | 12.01 | 27017623 | |
| 410 | Phosphorylation | SKNSVSYTLAETSKK CCCCCCEEEEECCCC | 16.40 | 30377154 | |
| 414 | Phosphorylation | VSYTLAETSKKMWLP CCEEEEECCCCEEEE | 39.99 | 30377154 | |
| 415 | Phosphorylation | SYTLAETSKKMWLPV CEEEEECCCCEEEEC | 23.06 | 27017623 | |
| 428 | Acetylation | PVSKNPRKNVSASYI ECCCCCCCCCCHHHC | 64.06 | 22865919 | |
| 533 | Phosphorylation | LDPNSDLSSDSINGT CCCCCCCCCCCCCCC | 36.77 | 21551504 | |
| 534 | Phosphorylation | DPNSDLSSDSINGTS CCCCCCCCCCCCCCC | 42.55 | 21551504 | |
| 536 | Phosphorylation | NSDLSSDSINGTSAT CCCCCCCCCCCCCCC | 21.65 | 21551504 | |
| 562 | Phosphorylation | PSLSSSSSVNLNNGS CCCCCCCCEECCCCC | 19.57 | 21551504 | |
| 579 | Phosphorylation | AAASDLSSANRRFSI CCHHHCCCCCHHHCH | 36.54 | 21551504 | |
| 588 | Acetylation | NRRFSIEKSIKDFFN CHHHCHHHHHHHHHC | 56.67 | 24489116 | |
| 591 | Acetylation | FSIEKSIKDFFNPEL HCHHHHHHHHHCHHH | 56.42 | 24489116 | |
| 637 | Acetylation | ETLLVHLKKFRFNGT CEEEEEEEECCCCCC | 34.68 | 24489116 | |
| 753 | Phosphorylation | AMATGNVTSKSKQEQ HHHHCCCCCHHHHHH | 34.14 | 27017623 | |
| 754 | Phosphorylation | MATGNVTSKSKQEQA HHHCCCCCHHHHHHH | 30.56 | 27017623 | |
| 756 | Phosphorylation | TGNVTSKSKQEQAVN HCCCCCHHHHHHHCC | 39.06 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBP10_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP10_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP10_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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