GEA1_YEAST - dbPTM
GEA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GEA1_YEAST
UniProt AC P47102
Protein Name ARF guanine-nucleotide exchange factor 1
Gene Name GEA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1408
Subcellular Localization Cytoplasm, cytosol. Membrane
Peripheral membrane protein. Soluble and partially membrane-bound.
Protein Description Activates the ARF proteins by exchanging bound GDP for free GTP..
Protein Sequence MHDVPMETVLAVNPATMIVKECINLCSAMNKQSRDKSQTSVAALLGGGSDIFLSQSDSFVDSFHNLPTSSYHDPLISGLVQLRLKINDLKGLDSLNALELLKPFLEIVSASSVSGYTTSLALDSLQKVFTLKIINKTFNDIQIAVRETVVALTHCRFEASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTLSLACNTQRSEVLRKTAEVTIAGITVKLFTKLKLLDPPTKTEKYINDESYTDNNLKDDIIGTTTSDNDLSSTDDDSAVADDNKNEKPVQQVIREQENDEETAEKAENVEPNYGITVIKDYLGLLLSLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSLISDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVSKQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLPAAAVNTSNNIPPICLEGVLSLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCVETFNEKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLKEFIDLFDFKGLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIHVQPDADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQRDFTNPISKLAQIDILQYEKAIFSNVRDIILKTLFKIFTVASSDQISLRILDAISKCTFINYYFSFDQSYNDTVLHLGEMTTLAQSSAKAVELDVDSIPLVEIFVEDTGSKISVSNQSIRLGQNFKAQLCTVLYFQIIKEISDPSIVSTRLWNQIVQLILKLFENLLMEPNLPFFTNFHSLLKLPELPLPDPDISIRKAKMSRSLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFENNQLVSPKMIETLLSSLVIEKTSENSPYFEQELLFLLEISIILISEASYGQEFGALIADHMINISNLDGLSKEAIARLASYKMFLVSRFDNPRDILSDLIEHDFLVKNEIFNTKYYESEWGKQVINDLFTHLNDVKYNERALKNVKFWNFLRILISAKDRQFAVYTFLEKYIQNGDIFVDDGNFMNILSLLDEMSCAGAVGTKWEQNYENSVEDGCEAPESNPYRSIIDLSSRSINITADLLSTVGRSNSALNKNEIIAAIQGLAHQCLNPCDELGMQALQALENILLSRASQLRTEKVAVDNLLETGLLPIFELDEIQDVKMKRITSILSVLSKIFLGQLVEGVTSNETFLRVLNVFNKYVDDPTVERQLQELIISKREIEKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
49PhosphorylationAALLGGGSDIFLSQS
HHHHCCCCCEEECCC		30.70-
241PhosphorylationLLDPPTKTEKYINDE
CCCCCCCCCCCCCCC		39.9427017623
262PhosphorylationLKDDIIGTTTSDNDL
CCCCEEEECCCCCCC		19.2528889911
263PhosphorylationKDDIIGTTTSDNDLS
CCCEEEECCCCCCCC		21.0621551504
264PhosphorylationDDIIGTTTSDNDLSS
CCEEEECCCCCCCCC		33.6428889911
265PhosphorylationDIIGTTTSDNDLSST
CEEEECCCCCCCCCC		32.1221551504
270PhosphorylationTTSDNDLSSTDDDSA
CCCCCCCCCCCCCCC		33.7721551504
271PhosphorylationTSDNDLSSTDDDSAV
CCCCCCCCCCCCCCC		43.0621551504
272PhosphorylationSDNDLSSTDDDSAVA
CCCCCCCCCCCCCCC		39.8228889911
276PhosphorylationLSSTDDDSAVADDNK
CCCCCCCCCCCCCCC		31.4728889911
770PhosphorylationDAWNNLISSTSVMTE
HHHHHHHHCHHHHHH		30.6327017623
983PhosphorylationRKAKMSRSLLSTFAS
HHHHHHHHHHHHHHH		26.7621440633
1170UbiquitinationERALKNVKFWNFLRI
HHHHHHCCHHHHHHH		54.8017644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GEA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GEA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GEA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GMH1_YEASTGMH1physical
12808035
YPT31_YEASTYPT31genetic
10430582
YPT32_YEASTYPT32genetic
10430582
ARF2_YEASTARF2genetic
12808035
GMH1_YEASTGMH1genetic
12808035
GEA2_YEASTGEA2genetic
14668359
GEA2_YEASTGEA2genetic
11294905
GEA2_YEASTGEA2genetic
16269340
OST1_YEASTOST1genetic
16269340
GRP78_YEASTKAR2genetic
16269340
UPPS_YEASTNUS1genetic
16269340
COPG_YEASTSEC21physical
19039328
GEA2_YEASTGEA2genetic
11493664
COPG_YEASTSEC21genetic
11493664
COPB2_YEASTSEC27genetic
11493664
TRS65_YEASTTRS65genetic
21813735
GEA2_YEASTGEA2physical
11294905
VPS64_YEASTVPS64physical
22875988
KEL1_YEASTKEL1physical
22875988
NTR2_YEASTNTR2physical
22875988
SNF7_YEASTSNF7physical
22875988
GEA2_YEASTGEA2genetic
23891562
ARF1_YEASTARF1genetic
23891562
MSMO_YEASTERG25genetic
23891562
CSG2_YEASTCSG2genetic
23891562
LIP1_YEASTLIP1genetic
27708008
RPC6_YEASTRPC34genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
CDC24_YEASTCDC24genetic
27708008
CDC27_YEASTCDC27genetic
27708008
ALG14_YEASTALG14genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
CDK1_YEASTCDC28genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRP9_YEASTPRP9genetic
27708008
FAL1_YEASTFAL1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
GPI19_YEASTGPI19genetic
27708008
RSP5_YEASTRSP5genetic
27708008
PRS7_YEASTRPT1genetic
27708008
CDC3_YEASTCDC3genetic
27708008
SEC65_YEASTSEC65genetic
27708008
RNA1_YEASTRNA1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
RPB2_YEASTRPB2genetic
27708008
GRPE_YEASTMGE1genetic
27708008
IES1_YEASTIES1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
DBF2_YEASTDBF2genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
POM33_YEASTPOM33genetic
27708008
LDB18_YEASTLDB18genetic
27708008
PFD6_YEASTYKE2genetic
27708008
VAC14_YEASTVAC14genetic
27708008
TDA1_YEASTTDA1genetic
27708008
PET8_YEASTPET8genetic
27708008
LIPA_YEASTLIP5genetic
27708008
GEA2_YEASTGEA2genetic
28978742
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GEA1_YEAST

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Related Literatures of Post-Translational Modification

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