LIPA_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPA_YEAST
• UniProt AC: P32875
• Protein Name: Lipoyl synthase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03123}
• Gene Name: LIP5 {ECO:0000255|HAMAP-Rule:MF_03123}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 414
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives..
• Protein Sequence: MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	PSFADFVSGKASKMI CCHHHHHCCHHHHHH	34.27	30377154
109	Acetylation	MILDPLEKARQNTEE HHHHHHHHHHCCHHH	57.46	24489116
125	Acetylation	KKLPRWLKVPIPKGT HCCCCCCCCCCCCCC	38.72	24489116
173	Phosphorylation	DKSKATATIMLLGDT CHHHCEEEEEECCCC	11.54	27017623
197	Phosphorylation	VKTNRTPSKPDPMEP CCCCCCCCCCCCCCC	57.09	19779198
198	Acetylation	KTNRTPSKPDPMEPE CCCCCCCCCCCCCCC	55.43	24489116
207	Phosphorylation	DPMEPENTAEAIKRW CCCCCCCHHHHHHHH	24.98	19779198
247	Acetylation	TVRKIKQKAPNTLVE HHHHHHHHCCCCEEH	61.89	24489116
371	Acetylation	VEYVKPEKFDYWKER EEECCHHHCCHHHHH	52.65	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPA_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPA_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPA_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSK1_YEAST	PSK1	physical	16554755
RV167_YEAST	RVS167	physical	16554755
TRK1_YEAST	TRK1	physical	16554755
SEC65_YEAST	SEC65	physical	16554755
GBLP_YEAST	ASC1	physical	16554755
SSB2_YEAST	SSB2	physical	19536198
ELO3_YEAST	ELO3	genetic	22808036

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.