| UniProt ID | TRK1_YEAST | |
|---|---|---|
| UniProt AC | P12685 | |
| Protein Name | High-affinity potassium transport protein | |
| Gene Name | TRK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1235 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | This protein is required for high-affinity potassium transport.. | |
| Protein Sequence | MHFRRTMSRVPTLASLEIRYKKSFGHKFRDFIALCGHYFAPVKKYIFPSFIAVHYFYTISLTLITSILLYPIKNTRYIDTLFLAAGAVTQGGLNTVDINNLSLYQQIVLYIVCCISTPIAVHSCLAFVRLYWFERYFDGIRDSSRRNFKMRRTKTILERELTARTMTKNRTGTQRTSYPRKQAKTDDFQEKLFSGEMVNRDEQDSVHSDQNSHDISRDSSNNNTNHNGSSGSLDDFVKEDETDDNGEYQENNSYSTVGSSSNTVADESLNQKPKPSSLRFDEPHSKQRPARVPSEKFAKRRGSRDISPADMYRSIMMLQGKHEATAEDEGPPLVIGSPADGTRYKSNVNKLKKATGINGNKIKIRDKGNESNTDQNSVSSEANSTASVSDESSLHTNFGNKVPSLRTNTHRSNSGPIAITDNAETDKKHGPSIQFDITKPPRKISKRVSTFDDLNPKSSVLYRKKASKKYLMKHFPKARRIRQQIKRRLSTGSIEKNSSNNVSDRKPITDMDDDDDDDDNDGDNNEEYFADNESGDEDERVQQSEPHSDSELKSHQQQQEKHQLQQNLHRMYKTKSFDDNRSRAVPMERSRTIDMAEAKDLNELARTPDFQKMVYQNWKAHHRKKPNFRKRGWNNKIFEHGPYASDSDRNYPDNSNTGNSILHYAESILHHDGSHKNGSEEASSDSNENIYSTNGGSDHNGLNNYPTYNDDEEGYYGLHFDTDYDLDPRHDLSKGSGKTYLSWQPTIGRNSNFLGLTRAQKDELGGVEYRAIKLLCTILVVYYVGWHIVAFVMLVPWIILKKHYSEVVRDDGVSPTWWGFWTAMSAFNDLGLTLTPNSMMSFNKAVYPLIVMIWFIIIGNTGFPILLRCIIWIMFKISPDLSQMRESLGFLLDHPRRCFTLLFPKAATWWLLLTLAGLNITDWILFIILDFGSTVVKSLSKGYRVLVGLFQSVSTRTAGFSVVDLSQLHPSIQVSYMLMMYVSVLPLAISIRRTNVYEEQSLGLYGDMGGEPEDTDTEDDGNDEDDDEENESHEGQSSQRSSSNNNNNNNRKKKKKKKTENPNEISTKSFIGAHLRKQLSFDLWFLFLGLFIICICEGDKIKDVQEPNFNIFAILFEIVSAYGTVGLSLGYPDTNQSFSRQFTTLSKLVIIAMLIRGKNRGLPYSLDRAIILPSDRLEHIDHLEGMKLKRQARTNTEDPMTEHFKRSFTDVKHRWGALKRKTTHSRNPKRSSTTL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | RTMSRVPTLASLEIR CCCCCCCCCHHEEEE | 31.90 | 22890988 | |
| 15 | Phosphorylation | SRVPTLASLEIRYKK CCCCCCHHEEEEEEH | 29.64 | 22890988 | |
| 100 | N-linked_Glycosylation | LNTVDINNLSLYQQI CCCCCCCCCHHHHHH | 31.20 | - | |
| 155 | Phosphorylation | FKMRRTKTILERELT HHHHHHHHHHHHHHH | 30.13 | 23749301 | |
| 162 | Phosphorylation | TILERELTARTMTKN HHHHHHHHHHHCCCC | 14.89 | 21440633 | |
| 165 | Phosphorylation | ERELTARTMTKNRTG HHHHHHHHCCCCCCC | 27.08 | 21440633 | |
| 167 | Phosphorylation | ELTARTMTKNRTGTQ HHHHHHCCCCCCCCC | 25.26 | 24961812 | |
| 169 | N-linked_Glycosylation | TARTMTKNRTGTQRT HHHHCCCCCCCCCCC | 37.26 | - | |
| 205 | Phosphorylation | VNRDEQDSVHSDQNS CCHHHCCCCCCCCCC | 22.79 | 19795423 | |
| 208 | Phosphorylation | DEQDSVHSDQNSHDI HHCCCCCCCCCCCCC | 38.44 | 19795423 | |
| 216 | Phosphorylation | DQNSHDISRDSSNNN CCCCCCCCCCCCCCC | 35.77 | 27017623 | |
| 222 | N-linked_Glycosylation | ISRDSSNNNTNHNGS CCCCCCCCCCCCCCC | 59.66 | - | |
| 227 | N-linked_Glycosylation | SNNNTNHNGSSGSLD CCCCCCCCCCCCCHH | 54.86 | - | |
| 229 | Phosphorylation | NNTNHNGSSGSLDDF CCCCCCCCCCCHHHH | 36.52 | 28889911 | |
| 251 | N-linked_Glycosylation | DNGEYQENNSYSTVG CCCCCCCCCCCCCCC | 27.50 | - | |
| 268 | Phosphorylation | SNTVADESLNQKPKP CCCCCCHHHCCCCCC | 32.92 | 28889911 | |
| 307 | Phosphorylation | RRGSRDISPADMYRS HHCCCCCCHHHHHHH | 20.51 | 28889911 | |
| 337 | Phosphorylation | GPPLVIGSPADGTRY CCCEEEECCCCCCCH | 13.04 | 23749301 | |
| 346 | Phosphorylation | ADGTRYKSNVNKLKK CCCCCHHHHHHHHHH | 36.76 | 21551504 | |
| 369 | N-linked_Glycosylation | IKIRDKGNESNTDQN EEEECCCCCCCCCCC | 56.09 | - | |
| 383 | N-linked_Glycosylation | NSVSSEANSTASVSD CCCCHHHHCCCCCCC | 35.52 | - | |
| 396 | Phosphorylation | SDESSLHTNFGNKVP CCCHHHCCCCCCCCC | 37.22 | 21551504 | |
| 407 | Phosphorylation | NKVPSLRTNTHRSNS CCCCCCCCCCCCCCC | 50.16 | 21551504 | |
| 409 | Phosphorylation | VPSLRTNTHRSNSGP CCCCCCCCCCCCCCC | 20.32 | 27017623 | |
| 412 | Phosphorylation | LRTNTHRSNSGPIAI CCCCCCCCCCCCEEE | 27.95 | 22369663 | |
| 414 | Phosphorylation | TNTHRSNSGPIAITD CCCCCCCCCCEEEEC | 47.39 | 22369663 | |
| 449 | Phosphorylation | RKISKRVSTFDDLNP CCCCCCCCCCCCCCC | 27.65 | 27017623 | |
| 450 | Phosphorylation | KISKRVSTFDDLNPK CCCCCCCCCCCCCCC | 28.38 | 20377248 | |
| 490 | Phosphorylation | QQIKRRLSTGSIEKN HHHHHHHHCCCCCCC | 28.98 | 25704821 | |
| 491 | Phosphorylation | QIKRRLSTGSIEKNS HHHHHHHCCCCCCCC | 39.27 | 28889911 | |
| 493 | Phosphorylation | KRRLSTGSIEKNSSN HHHHHCCCCCCCCCC | 27.88 | 28889911 | |
| 497 | N-linked_Glycosylation | STGSIEKNSSNNVSD HCCCCCCCCCCCCCC | 37.57 | - | |
| 501 | N-linked_Glycosylation | IEKNSSNNVSDRKPI CCCCCCCCCCCCCCC | 36.30 | - | |
| 532 | N-linked_Glycosylation | NEEYFADNESGDEDE CHHHCCCCCCCCHHH | 41.73 | - | |
| 534 | Phosphorylation | EYFADNESGDEDERV HHCCCCCCCCHHHHH | 58.77 | 28889911 | |
| 548 | Phosphorylation | VQQSEPHSDSELKSH HHHCCCCCHHHHHHH | 54.25 | 24930733 | |
| 550 | Phosphorylation | QSEPHSDSELKSHQQ HCCCCCHHHHHHHHH | 48.09 | 28132839 | |
| 574 | Phosphorylation | NLHRMYKTKSFDDNR HHHHHHHCCCCCCCC | 17.90 | 30377154 | |
| 576 | Phosphorylation | HRMYKTKSFDDNRSR HHHHHCCCCCCCCCC | 38.86 | 23749301 | |
| 580 | N-linked_Glycosylation | KTKSFDDNRSRAVPM HCCCCCCCCCCCCCC | 45.75 | - | |
| 590 | Phosphorylation | RAVPMERSRTIDMAE CCCCCHHHCCCCHHH | 22.07 | 28889911 | |
| 592 | Phosphorylation | VPMERSRTIDMAEAK CCCHHHCCCCHHHHH | 23.68 | 17330950 | |
| 599 | Ubiquitination | TIDMAEAKDLNELAR CCCHHHHHCHHHHCC | 55.01 | 23749301 | |
| 645 | Phosphorylation | FEHGPYASDSDRNYP HCCCCCCCCCCCCCC | 31.63 | 25704821 | |
| 677 | N-linked_Glycosylation | HHDGSHKNGSEEASS CCCCCCCCCCCCCCC | 54.52 | - | |
| 746 | Phosphorylation | TYLSWQPTIGRNSNF EEEEEECCCCCCCCC | 22.44 | 28889911 | |
| 757 | Phosphorylation | NSNFLGLTRAQKDEL CCCCCCCCHHHHHCC | 23.35 | 28889911 | |
| 919 | N-linked_Glycosylation | LLTLAGLNITDWILF HHHHHCCCHHHHHHH | 33.91 | - | |
| 1030 | N-linked_Glycosylation | DEDDDEENESHEGQS CCCCCCCCCCCCCCH | 54.76 | - | |
| 1135 | N-linked_Glycosylation | SLGYPDTNQSFSRQF HCCCCCCCCCHHHHH | 42.76 | - | |
| 1143 | Phosphorylation | QSFSRQFTTLSKLVI CCHHHHHHHHHHHHH | 20.63 | 21126336 | |
| 1196 | Phosphorylation | KRQARTNTEDPMTEH HHHHCCCCCCCCHHH | 40.95 | 28889911 | |
| 1207 | Phosphorylation | MTEHFKRSFTDVKHR CHHHHHHHHHHHHHH | 32.84 | 21126336 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414, AND MASSSPECTROMETRY. | |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-450, AND MASSSPECTROMETRY. | |
