TSR3_YEAST - dbPTM
TSR3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSR3_YEAST
UniProt AC Q12094
Protein Name Ribosome biogenesis protein TSR3 {ECO:0000255|HAMAP-Rule:MF_03146}
Gene Name TSR3 {ECO:0000255|HAMAP-Rule:MF_03146}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 313
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Ribosome biogenesis protein required for processing 35S pre-rRNA at site D..
Protein Sequence MGKGKNKMHEPKNGRPQRGANGHSSRQNHRRMEMKYDNSEKMKFPVKLAMWDFDHCDPKRCSGKKLERLGLIKSLRVGQKFQGIVVSPNGKGVVCPDDLEIVEQHGASVVECSWARLEEVPFNKIGGKHERLLPYLVAANQVNYGRPWRLNCVEALAACFAIVGRMDWASELLSHFSWGMGFLELNKELLEIYQQCTDCDSVKRAEEEWLQKLEKETQERKSRAKEEDIWMMGNINRRGNGSQSDTSESEENSEQSDLEGNNQCIEYDSLGNAIRIDNMKSREAQSEESEDEESGSKENGEPLSYDPLGNLIR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35AcetylationNHRRMEMKYDNSEKM
HHHCCCCCCCCHHHC		35.8225381059
36PhosphorylationHRRMEMKYDNSEKMK
HHCCCCCCCCHHHCC		21.0321551504
74PhosphorylationERLGLIKSLRVGQKF
HHHCCHHHCCCCCEE		17.8921126336
281PhosphorylationIRIDNMKSREAQSEE
EEECCHHCCCCCCCC		25.2825521595
286PhosphorylationMKSREAQSEESEDEE
HHCCCCCCCCCCCCC		50.8325521595
289PhosphorylationREAQSEESEDEESGS
CCCCCCCCCCCCCCC		46.4225521595
294PhosphorylationEESEDEESGSKENGE
CCCCCCCCCCCCCCC		46.4422890988
296PhosphorylationSEDEESGSKENGEPL
CCCCCCCCCCCCCCC		46.1822890988
304PhosphorylationKENGEPLSYDPLGNL
CCCCCCCCCCCCCCC		37.9019779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSR3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSR3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSR3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LSM3_YEASTLSM3genetic
19061648
EF1B_YEASTEFB1genetic
19061648
TAD2_YEASTTAD2genetic
19061648
HIR2_YEASTHIR2genetic
19061648
DBP5_YEASTDBP5genetic
19061648
IMB4_YEASTKAP123genetic
19061648
KRR1_YEASTKRR1genetic
19061648
RRP7_YEASTRRP7genetic
19061648
PUS3_YEASTDEG1genetic
19061648
SKI2_YEASTSKI2genetic
19061648
RRP8_YEASTRRP8genetic
19061648
RLI1_YEASTRLI1genetic
19061648
ARC1_YEASTARC1genetic
19061648
DBP3_YEASTDBP3genetic
19061648
UTP18_YEASTUTP18genetic
19061648
MAK11_YEASTMAK11genetic
19061648
NOP15_YEASTNOP15genetic
19061648
TGS1_YEASTTGS1genetic
19061648
NOP16_YEASTNOP16genetic
19061648
PABP_YEASTPAB1genetic
19061648
ECM21_YEASTECM21genetic
27708008
TPS2_YEASTTPS2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
CDC27_YEASTCDC27genetic
27708008
NHP2_YEASTNHP2genetic
27708008
DAD1_YEASTDAD1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
CDC1_YEASTCDC1genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
RCC1_YEASTSRM1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
COPB2_YEASTSEC27genetic
27708008
GPI10_YEASTGPI10genetic
27708008
MPPA_YEASTMAS2genetic
27708008
BCD1_YEASTBCD1genetic
27708008
SHQ1_YEASTSHQ1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
SEC22_YEASTSEC22genetic
27708008
SEC39_YEASTSEC39genetic
27708008
CDC91_YEASTGAB1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
MYO2_YEASTMYO2genetic
27708008
IPL1_YEASTIPL1genetic
27708008
AIM2_YEASTAIM2genetic
27708008
QOR_YEASTZTA1genetic
27708008
BMT2_YEASTBMT2genetic
27708008
MBA1_YEASTMBA1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
PAT1_YEASTPAT1genetic
27708008
SNF3_YEASTSNF3genetic
27708008
DET1_YEASTDET1genetic
27708008
PAA1_YEASTPAA1genetic
27708008
IPT1_YEASTIPT1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
UBC13_YEASTUBC13genetic
27708008
ODO2_YEASTKGD2genetic
27708008
DHAS_YEASTHOM2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
HSP78_YEASTHSP78genetic
27708008
XRS2_YEASTXRS2genetic
27708008
BCS1_YEASTBCS1genetic
27708008
SAC7_YEASTSAC7genetic
27708008
SHE9_YEASTSHE9genetic
27708008
SIP2_YEASTSIP2genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
SNF6_YEASTSNF6genetic
27708008
SIC1_YEASTSIC1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
TGL3_YEASTTGL3genetic
27708008
DOM34_YEASTDOM34genetic
27708008
SUR1_YEASTSUR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSR3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286 AND SER-289, ANDMASS SPECTROMETRY.

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