TGL3_YEAST - dbPTM
TGL3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TGL3_YEAST
UniProt AC P40308
Protein Name Lipase 3
Gene Name TGL3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 642
Subcellular Localization Lipid droplet. Membrane
Multi-pass membrane protein. Lipid particle.
Protein Description Releases specific fatty acids from neutral lipid triacylglycerols (TAG) thereby supplying fatty acids to a general acylation process..
Protein Sequence MKETAQEYKVSAVIPTLLKNWILRVVYATLDHIPPFVWEILHVITDIYFFWVQKLINYVRPHSRVIYYNAIKKLDECDTYQMWCQQASVVDEITGANLWRRNFFSRRYDFNSVIEQYSILENMLREEKYDVVKEKFSTTGPCMLRNFAGIGDKKLFTKSLMGTKLLIEQYLTRILEGLDILNNQTLTPTSFFQRCKLSLGTTALILQGGSLFGLFHLGVIRGLLLQDLMPNIISGSSMGACVASLFGCLSNEQLKQLLTDDNLLNIIKNDVDLLKSCGYGNLEQHLNLGTLIQNLIHHGYSQDVYLFIRFVMKYIVKEKTFEEVYQITGKVFNIVIHPTDKSCPNLLNYVTTPNVLIKSAIECSLGSGVISEDTSLLCKNLENEIEPFLNINKNKQVKFLTPENANNPSITESPYTRLTELFNVNNFIVSLARPYLAPLVVNDLKHEIKTSKYYYYKHYPNMPPINANTVRKTQRSSSQSPIKAGTVEDLEPEPLMSPVPPSSAVNDSAEYIIPELGIPQLNFTEMEPLAFKFKYHLERKLKNIATMEFRHRMEVLDNLGLLCSLIKRLIIDEKTPRSATEIAVVPRMKSLSLTRIIEGQLNNIPYWIKSGERSTWPALALIKTRCAVEFKLDDIIRARRSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
129PhosphorylationNMLREEKYDVVKEKF
HHHHHHCCHHHHHHH		19.7628889911
445AcetylationPLVVNDLKHEIKTSK
HHHHCHHHHHHHHCC		41.8924489116
457AcetylationTSKYYYYKHYPNMPP
HCCCEECCCCCCCCC		22.1224489116
473PhosphorylationNANTVRKTQRSSSQS
CHHHCCCCCCCCCCC		20.7419795423
476PhosphorylationTVRKTQRSSSQSPIK
HCCCCCCCCCCCCCC		25.2319823750
477PhosphorylationVRKTQRSSSQSPIKA
CCCCCCCCCCCCCCC		34.2919823750
478PhosphorylationRKTQRSSSQSPIKAG
CCCCCCCCCCCCCCC		35.6019823750
480PhosphorylationTQRSSSQSPIKAGTV
CCCCCCCCCCCCCCC		30.4627214570
590PhosphorylationAVVPRMKSLSLTRII
EEEECCCCCCCCHHH		17.5326447709
592PhosphorylationVPRMKSLSLTRIIEG
EECCCCCCCCHHHHC		34.4826447709
594PhosphorylationRMKSLSLTRIIEGQL
CCCCCCCCHHHHCCH		19.2226447709
614PhosphorylationWIKSGERSTWPALAL
EHHCCCCCCCHHHHH		30.4421126336
615PhosphorylationIKSGERSTWPALALI
HHCCCCCCCHHHHHH		41.5121126336
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TGL3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TGL3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TGL3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TGL4_YEASTTGL4genetic
16267052
MGA2_YEASTMGA2genetic
16269340
TSC3_YEASTTSC3genetic
16269340
RGP1_YEASTRGP1genetic
16269340
LPP1_YEASTLPP1genetic
16269340
ATC6_YEASTSPF1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
SIN3_YEASTSIN3genetic
19547744
COX5A_YEASTCOX5Agenetic
21623372
KCS1_YEASTKCS1genetic
21623372
CY1_YEASTCYT1genetic
21623372
COX10_YEASTCOX10genetic
21623372
GPP2_YEASTGPP2genetic
21623372
OM14_YEASTOM14physical
21748599
ARPC5_YEASTARC15physical
21748599
AYR1_YEASTAYR1physical
21748599
PEX19_YEASTPEX19physical
21748599
TGL3_YEASTTGL3physical
22940862
CSG2_YEASTCSG2genetic
23891562
SWE1_YEASTSWE1genetic
25713391
CDK1_YEASTCDC28genetic
25713391
2ABA_YEASTCDC55genetic
25713391
IMG2_YEASTIMG2genetic
27708008
MGA2_YEASTMGA2genetic
27708008
ALDH6_YEASTALD6genetic
27708008
TOR1_YEASTTOR1genetic
26907989
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TGL3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-478, AND MASSSPECTROMETRY.

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