LPP1_YEAST - dbPTM
LPP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LPP1_YEAST
UniProt AC Q04396
Protein Name Lipid phosphate phosphatase 1
Gene Name LPP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 274
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein .
Protein Description Catalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA..
Protein Sequence MISVMADEKHKEYFKLYYFQYMIIGLCTILFLYSEISLVPRGQNIEFSLDDPSISKRYVPNELVGPLECLILSVGLSNMVVFWTCMFDKDLLKKNRVKRLRERPDGISNDFHFMHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSDSDSLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLWQRVFTTRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWTFTNLAKRDILPSPVSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationHKEYFKLYYFQYMII
HHHHHHHHHHHHHHH		11.6529688323
18PhosphorylationKEYFKLYYFQYMIIG
HHHHHHHHHHHHHHH		8.4729688323
21PhosphorylationFKLYYFQYMIIGLCT
HHHHHHHHHHHHHHH		4.7529688323
28PhosphorylationYMIIGLCTILFLYSE
HHHHHHHHHHHHHHH		26.2629688323
33PhosphorylationLCTILFLYSEISLVP
HHHHHHHHHHHCCCC		9.2729688323
34PhosphorylationCTILFLYSEISLVPR
HHHHHHHHHHCCCCC		30.5129688323
37PhosphorylationLFLYSEISLVPRGQN
HHHHHHHCCCCCCCC		21.1829688323
270PhosphorylationAKRDILPSPVSV---
HHCCCCCCCCCC---		34.1928889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LPP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LPP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LPP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHE2_YEASTSHE2physical
10688190
BFR1_YEASTBFR1genetic
16269340
ERG5_YEASTERG5genetic
16269340
PFD2_YEASTGIM4genetic
16269340
TGL3_YEASTTGL3genetic
16269340
ATC1_YEASTPMR1genetic
16269340
PER1_YEASTPER1genetic
16269340
RBD2_YEASTRBD2physical
18467557
TMN3_YEASTTMN3physical
18467557
LPP1_YEASTLPP1physical
18467557
CTK2_YEASTCTK2genetic
19269370
CTK3_YEASTCTK3genetic
19269370
MET22_YEASTMET22genetic
21623372
TREA_YEASTNTH1genetic
21623372
YEH1_YEASTYEH1genetic
21623372
PAH1_YEASTPAH1genetic
24196957
RPB1_YEASTRPO21genetic
27708008
CDC1_YEASTCDC1genetic
27708008
GPI8_YEASTGPI8genetic
27708008
ACT_YEASTACT1genetic
27708008
FDFT_YEASTERG9genetic
27708008
CDC91_YEASTGAB1genetic
27708008
CH10_YEASTHSP10genetic
27708008
GRPE_YEASTMGE1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LPP1_YEAST

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Related Literatures of Post-Translational Modification

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