YEH1_YEAST - dbPTM
YEH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YEH1_YEAST
UniProt AC Q07804
Protein Name Sterol esterase 1
Gene Name YEH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 573
Subcellular Localization Lipid droplet. Membrane
Peripheral membrane protein.
Protein Description Mediates the hydrolysis of steryl esters, thereby playing a central role in lipid metabolism. Under heme-deficient conditions, it constitutes the major steryl ester hydrolase, suggesting that it plays a central role in mobilization of steryl esters under anaerobic conditions..
Protein Sequence MGVSAVLKRARNLLATFIVCCFMAVVLVLALAHHFINEHRDTRSSSTQIEVDDESKRNVHHDHVLTRTNAYATPYLDLEHDKKNGIVYDHTRTVVRKKNHEVGSSSLHKNLFHKFLTKLIFRFIEKEKVTEGVTQGKFNNSSNEIANHEPVFEKIPVQCDNPLQNLILSEDLTLVADLNYYFNQYNIQIEEFRLETEDGFVIDLWHLIPKYRTTDSDKKKRPPILMLHGLLQSSGSFASNGRKSLAYFLYQSGYDIWLGNNRCGFRPEWNEAKVPTLASRWDWDLREMVKYDLTLLIDTVLAKTQFEKLTLISHSQGTTQGFMGLVNEDKFFPPGSGSKESFFTSKIANYIALAPAVYPGPLLNEKLFVKLMTKEIENPWFFGETSFFEIMMIVRNLCVGESLFSFVCYTIFNYLFDWNDTLWDTALRDRHFLFSPVHVSVKLMQWWLSPDPNKVSFKFGSHKMFPDNVKWFSDASKAPNIYLFVPKQDRLVDGERLINHFVNVESNVNYKIWYIDEYAHIDVLWAHDVIERIGKPILQNLNNYYSKKPSSAFESDCSDTEVETELEMVAEKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56UbiquitinationIEVDDESKRNVHHDH
EEECCCHHCCCCCCC		46.0423749301
82UbiquitinationYLDLEHDKKNGIVYD
CCCCCCCCCCCEEEE		50.4723749301
83UbiquitinationLDLEHDKKNGIVYDH
CCCCCCCCCCEEEEC		67.4717644757
104PhosphorylationKKNHEVGSSSLHKNL
CCCCCCCCCHHHHHH		23.1729136822
105PhosphorylationKNHEVGSSSLHKNLF
CCCCCCCCHHHHHHH		30.8729136822
106PhosphorylationNHEVGSSSLHKNLFH
CCCCCCCHHHHHHHH		35.8729136822
114AcetylationLHKNLFHKFLTKLIF
HHHHHHHHHHHHHHH		34.4324489116
118AcetylationLFHKFLTKLIFRFIE
HHHHHHHHHHHHHHH		41.5524489116
126UbiquitinationLIFRFIEKEKVTEGV
HHHHHHHHHCCCCCC		59.0017644757
128UbiquitinationFRFIEKEKVTEGVTQ
HHHHHHHCCCCCCCC		66.5817644757
137UbiquitinationTEGVTQGKFNNSSNE
CCCCCCCCCCCCCCC		34.7923749301
141PhosphorylationTQGKFNNSSNEIANH
CCCCCCCCCCCCCCC		35.3327214570
142PhosphorylationQGKFNNSSNEIANHE
CCCCCCCCCCCCCCC		40.3727214570
243UbiquitinationSFASNGRKSLAYFLY
CHHHCCHHHHHHHHH		51.7417644757
273UbiquitinationRPEWNEAKVPTLASR
CCCCCCCCCCCCHHC		42.4423749301
291PhosphorylationDLREMVKYDLTLLID
CHHHHHHHHHHHHHH		12.5521126336
294PhosphorylationEMVKYDLTLLIDTVL
HHHHHHHHHHHHHHH		19.3421126336
303UbiquitinationLIDTVLAKTQFEKLT
HHHHHHHHHHHHEEE		38.4023749301
341PhosphorylationPGSGSKESFFTSKIA
CCCCCHHHHHHHHHH		29.4219779198
346UbiquitinationKESFFTSKIANYIAL
HHHHHHHHHHHHHHH		42.6617644757
366UbiquitinationPGPLLNEKLFVKLMT
CCCCCCHHHHHHHHH		46.2617644757
458UbiquitinationDPNKVSFKFGSHKMF
CCCCEEEEECCCCCC		41.1122817900
463UbiquitinationSFKFGSHKMFPDNVK
EEEECCCCCCCCCCC		43.8923749301
477UbiquitinationKWFSDASKAPNIYLF
CCCCCCCCCCCEEEE		70.3717644757
487UbiquitinationNIYLFVPKQDRLVDG
CEEEECCCHHCCCCH		60.5724961812
511UbiquitinationVESNVNYKIWYIDEY
CCCCCCEEEEEEECC		22.8917644757
535UbiquitinationDVIERIGKPILQNLN
HHHHHHCHHHHHHHH		26.8923749301
547UbiquitinationNLNNYYSKKPSSAFE
HHHHHCCCCCCHHCC		53.2117644757
548UbiquitinationLNNYYSKKPSSAFES
HHHHCCCCCCHHCCC		44.1617644757
550PhosphorylationNYYSKKPSSAFESDC
HHCCCCCCHHCCCCC		43.0823749301
551PhosphorylationYYSKKPSSAFESDCS
HCCCCCCHHCCCCCC		45.5719779198
555PhosphorylationKPSSAFESDCSDTEV
CCCHHCCCCCCCCHH		37.1523749301
558PhosphorylationSAFESDCSDTEVETE
HHCCCCCCCCHHHHH		53.1923749301
560PhosphorylationFESDCSDTEVETELE
CCCCCCCCHHHHHHH		26.1519823750
564PhosphorylationCSDTEVETELEMVAE
CCCCHHHHHHHHHHH		51.5519823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YEH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YEH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YEH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ERG27_YEASTERG27physical
18467557
CSG2_YEASTCSG2genetic
21623372
THI6_YEASTTHI6genetic
21623372
COX6_YEASTCOX6genetic
21623372
AYR1_YEASTAYR1physical
21748599
YEH1_YEASTYEH1physical
22940862
HSP72_YEASTSSA2physical
22940862
SSB1_YEASTSSB1physical
22940862
G3P3_YEASTTDH3physical
22940862
HSP71_YEASTSSA1physical
22940862
ENO2_YEASTENO2physical
22940862
EF1A_YEASTTEF2physical
22940862
DED1_YEASTDED1physical
22940862
KPYK1_YEASTCDC19physical
22940862
MAS5_YEASTYDJ1physical
22940862
TCPZ_YEASTCCT6genetic
27708008
ACT_YEASTACT1genetic
27708008
BIG1_YEASTBIG1genetic
27708008
NU192_YEASTNUP192genetic
27708008
TIM16_YEASTPAM16genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
KTHY_YEASTCDC8genetic
27708008
SEC22_YEASTSEC22genetic
27708008
MCM1_YEASTMCM1genetic
27708008
ROT1_YEASTROT1genetic
27708008
CAP_YEASTSRV2genetic
27708008
NAB3_YEASTNAB3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YEH1_YEAST

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Related Literatures of Post-Translational Modification

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