THI6_YEAST - dbPTM
THI6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THI6_YEAST
UniProt AC P41835
Protein Name Thiamine biosynthetic bifunctional enzyme
Gene Name THI6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 540
Subcellular Localization
Protein Description Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole.; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)..
Protein Sequence MVFTKEEVDYSLYLVTDSTMLPPGTTLCSQVEAGLKNGVTLVQIREKDIETKNFVAEALEVQKICKKYNVPLIINDRIDVAMAIDADGVHVGQDDMPIPMVRKLLGPSKILGWSVGKPSEVETLAKWGPDMVDYIGVGTLFPTSTKKNPKKSPMGPQGAIAILDALEEFKATWCRTVGIGGLHPDNIQRVLCQCVASNGKRSLDGISLVSDIMAAPDACAATKRLRGLLDATRYQFVECELNNTFPTTTSIQNVISQVSNNRPLVQHITNKVHQNFGANVTLALGSSPIMSEIESEVSELARIPNASLLLNTGSVAPIEMLKAAINAYNEVNRPITFDPVGYSATETRLCLNNTLLTYGQFACIKGNCSEILSLAKLNNHKMKGVDSSSGKTNIDTLVRATQIVAFQYRTVAVCTGEFDCVADGTFGGEYKLSSGTEGITAEDLPCVIIEDGPIPIMGDITASGCSLGSTIASFIGGLDSTGKLFDAVVGAVLLYKSAGKLASTRCQGSGSFHVELIDALYQLFHENKPEKWSASLKKFK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
47AcetylationTLVQIREKDIETKNF
EEEEEEHHHCCCCHH		54.9124489116
222PhosphorylationAPDACAATKRLRGLL
CCCHHHHHHHHHHHH		9.7328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THI6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THI6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THI6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
THI6_YEASTTHI6physical
10688190
RPB1_YEASTRPO21genetic
17314980
SWR1_YEASTSWR1genetic
17314980
RSC8_YEASTRSC8genetic
17314980
AF9_YEASTYAF9genetic
17314980
TBF1_YEASTTBF1genetic
17314980
NGG1_YEASTNGG1genetic
17314980
SWC3_YEASTSWC3genetic
17314980
LSM6_YEASTLSM6genetic
17314980
VPS71_YEASTVPS71genetic
17314980
SWC5_YEASTSWC5genetic
17314980
SNU66_YEASTSNU66genetic
17314980
TAF13_YEASTTAF13genetic
17314980
CTI6_YEASTCTI6genetic
17314980
HCM1_YEASTHCM1genetic
17314980
CTR9_YEASTCTR9genetic
17314980
BRE5_YEASTBRE5genetic
17314980
DEP1_YEASTDEP1genetic
17314980
MED2_YEASTMED2genetic
17314980
RTG3_YEASTRTG3genetic
17314980
SPT21_YEASTSPT21genetic
17314980
CDC73_YEASTCDC73genetic
17314980
IES2_YEASTIES2genetic
17314980
SWR1_YEASTSWR1genetic
19269370
LSM6_YEASTLSM6genetic
19269370
ELP2_YEASTELP2genetic
19269370
DOA1_YEASTDOA1genetic
19269370
IES3_YEASTIES3genetic
19269370
VPS71_YEASTVPS71genetic
19269370
BRE5_YEASTBRE5genetic
19269370
KCC2_YEASTCMK2genetic
19269370
CTI6_YEASTCTI6genetic
19269370
APA1_YEASTAPA1genetic
21623372
FOLE_YEASTMET7genetic
21623372
ACON2_YEASTACO2genetic
21623372
SEC22_YEASTSEC22genetic
27708008
GPR1_YEASTGPR1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
RS3A2_YEASTRPS1Bgenetic
27708008
SIW14_YEASTSIW14genetic
27708008
INO4_YEASTINO4genetic
27708008
AAR2_YEASTAAR2genetic
27708008
EXO84_YEASTEXO84genetic
27708008
CALM_YEASTCMD1genetic
27708008
MCM7_YEASTMCM7genetic
27708008
PRP5_YEASTPRP5genetic
27708008
APC11_YEASTAPC11genetic
27708008
PRP11_YEASTPRP11genetic
27708008
NSE4_YEASTNSE4genetic
27708008
NOP14_YEASTNOP14genetic
27708008
MAK21_YEASTMAK21genetic
27708008
UTP5_YEASTUTP5genetic
27708008
SYF1_YEASTSYF1genetic
27708008
ACT_YEASTACT1genetic
27708008
RSC8_YEASTRSC8genetic
27708008
PRS8_YEASTRPT6genetic
27708008
MPPA_YEASTMAS2genetic
27708008
KTHY_YEASTCDC8genetic
27708008
ARP3_YEASTARP3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
PRS7_YEASTRPT1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
SEC39_YEASTSEC39genetic
27708008
ERO1_YEASTERO1genetic
27708008
RRP5_YEASTRRP5genetic
27708008
DCP2_YEASTDCP2genetic
27708008
PRP2_YEASTPRP2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
PUF3_YEASTPUF3genetic
27708008
THI7_YEASTTHI7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THI6_YEAST

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Related Literatures of Post-Translational Modification

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