| UniProt ID | RSC8_YEAST | |
|---|---|---|
| UniProt AC | P43609 | |
| Protein Name | Chromatin structure-remodeling complex protein RSC8 | |
| Gene Name | RSC8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 557 | |
| Subcellular Localization | Nucleus . Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1. | |
| Protein Description | Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and for repression of CHA1 expression.. | |
| Protein Sequence | MSDTEKDKDVPMVDSHEATEEPPTTSTNTPSFPHLAQEQAKEESATLGAEVAHKKINYEQEAQKLEEKALRFLAKQTHPVIIPSFASWFDISKIHEIEKRSNPDFFNDSSRFKTPKAYKDTRNFIINTYRLSPYEYLTITAVRRNVAMDVASIVKIHAFLEKWGLINYQIDPRTKPSLIGPSFTGHFQVVLDTPQGLKPFLPENVIKQEVEGGDGAEPQVKKEFPVNLTIKKNVYDSAQDFNALQDESRNSRQIHKVYICHTCGNESINVRYHNLRARDTNLCSRCFQEGHFGANFQSSDFIRLENNGNSVKKNWSDQEMLLLLEGIEMYEDQWEKIADHVGGHKRVEDCIEKFLSLPIEDNYIREVVGSTLNGKGGDSRDGSVSGSKLMECVNDAVQTLLQGDDKLGKVSDKSREISEKYIEESQAIIQELVKLTMEKLESKFTKLCDLETQLEMEKLKYVKESEKMLNDRLSLSKQILDLNKSLEELNVSKKLVLISEQVDSGIQLVEKDQEGDDEDGNTATGHGVKRVGKEGEEVGEGDSIAKLQPQVYKPWSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSDTEKDKD ------CCCCCCCCC | 53.92 | 29136822 | |
| 4 | Phosphorylation | ----MSDTEKDKDVP ----CCCCCCCCCCC | 37.31 | 24961812 | |
| 15 | Phosphorylation | KDVPMVDSHEATEEP CCCCCCCCCCCCCCC | 16.30 | 20377248 | |
| 19 | Phosphorylation | MVDSHEATEEPPTTS CCCCCCCCCCCCCCC | 37.59 | 29136822 | |
| 24 | Phosphorylation | EATEEPPTTSTNTPS CCCCCCCCCCCCCCC | 44.06 | 21440633 | |
| 25 | Phosphorylation | ATEEPPTTSTNTPSF CCCCCCCCCCCCCCC | 39.05 | 21551504 | |
| 26 | Phosphorylation | TEEPPTTSTNTPSFP CCCCCCCCCCCCCCH | 23.34 | 21440633 | |
| 27 | Phosphorylation | EEPPTTSTNTPSFPH CCCCCCCCCCCCCHH | 40.81 | 21551504 | |
| 29 | Phosphorylation | PPTTSTNTPSFPHLA CCCCCCCCCCCHHHH | 22.01 | 20377248 | |
| 31 | Phosphorylation | TTSTNTPSFPHLAQE CCCCCCCCCHHHHHH | 49.74 | 20377248 | |
| 44 | Phosphorylation | QEQAKEESATLGAEV HHHHHHHHHHHHHHH | 27.87 | 29136822 | |
| 46 | Phosphorylation | QAKEESATLGAEVAH HHHHHHHHHHHHHHH | 34.70 | 29136822 | |
| 64 | Acetylation | NYEQEAQKLEEKALR CHHHHHHHHHHHHHH | 65.98 | 24489116 | |
| 68 | Acetylation | EAQKLEEKALRFLAK HHHHHHHHHHHHHHH | 43.26 | 24489116 | |
| 134 | Phosphorylation | NTYRLSPYEYLTITA EEEECCHHHHHHHHH | 17.52 | 28889911 | |
| 136 | Phosphorylation | YRLSPYEYLTITAVR EECCHHHHHHHHHHH | 11.87 | 28889911 | |
| 138 | Phosphorylation | LSPYEYLTITAVRRN CCHHHHHHHHHHHCC | 18.51 | 28889911 | |
| 140 | Phosphorylation | PYEYLTITAVRRNVA HHHHHHHHHHHCCCC | 17.54 | 28889911 | |
| 232 | Ubiquitination | PVNLTIKKNVYDSAQ CCCEEEEECCCCCHH | 48.04 | 23749301 | |
| 237 | Phosphorylation | IKKNVYDSAQDFNAL EEECCCCCHHHHHHH | 15.33 | 22369663 | |
| 284 | Phosphorylation | ARDTNLCSRCFQEGH CCCCCHHHHHHHCCC | 34.94 | 30377154 | |
| 370 | Phosphorylation | YIREVVGSTLNGKGG CHHHHHCCCCCCCCC | 20.36 | 21440633 | |
| 371 | Phosphorylation | IREVVGSTLNGKGGD HHHHHCCCCCCCCCC | 20.50 | 24961812 | |
| 375 | Ubiquitination | VGSTLNGKGGDSRDG HCCCCCCCCCCCCCC | 59.66 | 23749301 | |
| 379 | Phosphorylation | LNGKGGDSRDGSVSG CCCCCCCCCCCCCCH | 35.23 | 21440633 | |
| 383 | Phosphorylation | GGDSRDGSVSGSKLM CCCCCCCCCCHHHHH | 19.87 | 25752575 | |
| 385 | Phosphorylation | DSRDGSVSGSKLMEC CCCCCCCCHHHHHHH | 38.76 | 21440633 | |
| 418 | Phosphorylation | SDKSREISEKYIEES CHHHHHHHHHHHHHH | 24.23 | 24909858 | |
| 421 | Phosphorylation | SREISEKYIEESQAI HHHHHHHHHHHHHHH | 14.98 | 22369663 | |
| 425 | Phosphorylation | SEKYIEESQAIIQEL HHHHHHHHHHHHHHH | 16.48 | 22369663 | |
| 439 | Ubiquitination | LVKLTMEKLESKFTK HHHHHHHHHHHHHHH | 46.89 | 23749301 | |
| 442 | Phosphorylation | LTMEKLESKFTKLCD HHHHHHHHHHHHHCC | 43.43 | 21126336 | |
| 443 | Acetylation | TMEKLESKFTKLCDL HHHHHHHHHHHHCCH | 47.91 | 25381059 | |
| 446 | Ubiquitination | KLESKFTKLCDLETQ HHHHHHHHHCCHHHH | 50.69 | 23749301 | |
| 458 | Ubiquitination | ETQLEMEKLKYVKES HHHHHHHHHHHHHHH | 49.31 | 23749301 | |
| 485 | Phosphorylation | QILDLNKSLEELNVS HHHHHHHHHHHCCCC | 39.68 | 22369663 | |
| 492 | Phosphorylation | SLEELNVSKKLVLIS HHHHCCCCCEEEEEE | 24.01 | 22369663 | |
| 522 | Phosphorylation | GDDEDGNTATGHGVK CCCCCCCCCCCCCCE | 31.00 | 21551504 | |
| 524 | Phosphorylation | DEDGNTATGHGVKRV CCCCCCCCCCCCEEC | 27.89 | 27717283 | |
| 529 | Acetylation | TATGHGVKRVGKEGE CCCCCCCEECCCCCC | 46.06 | 22865919 | |
| 533 | Acetylation | HGVKRVGKEGEEVGE CCCEECCCCCCCCCC | 60.74 | 25381059 | |
| 543 | Phosphorylation | EEVGEGDSIAKLQPQ CCCCCCCCCCCCCCC | 34.99 | 23749301 | |
| 546 | Acetylation | GEGDSIAKLQPQVYK CCCCCCCCCCCCCCC | 46.08 | 24489116 | |
| 553 | Acetylation | KLQPQVYKPWSL--- CCCCCCCCCCCC--- | 40.95 | 24489116 | |
| 556 | Phosphorylation | PQVYKPWSL------ CCCCCCCCC------ | 32.50 | 21551504 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RSC8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RSC8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RSC8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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