| UniProt ID | RSC58_YEAST | |
|---|---|---|
| UniProt AC | Q07979 | |
| Protein Name | Chromatin structure-remodeling complex protein RSC58 | |
| Gene Name | RSC58 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 502 | |
| Subcellular Localization | Nucleus . Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1. | |
| Protein Description | Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.. | |
| Protein Sequence | MTESVGGNKLVDFLVNVQSILNAASVKCHVVDESFPAKFFEKNPDKIYESYCKFIKNRSNSEGLIRNEDKLVLTTINKRFENGEYEPIQGGFYKLYHDIKLVCTILIHFYPQGTRNYQLVDKFYKFSSELLLRECCRIGIALTQTNNIKSRSGKLLSGNEMDEYDDDDATELDKIISYDFIKISMNYTVPISQTYQIRTKDMDLFSSIISKSNLDKRPHELPNTNFKINNVLPQTDIENEAPRLGFVGANTSNIPDPTLPPTEMMTRFLHPNWYALPTTVWLKYGNYNSWAPSFNENGTVVDSTTRGLIWLERIGYMDLYEKNEKKVKQEELLNTNEEGINRKQNDENNKNVDGKSNGVQDDGGDNDNDATIASANSESTENKEQFIIKLQNLYNWTPSNYIGDDEIENFRNGTPDKLVSDSLLKLKRLRKERILNKVLKPTTEERELYFKVKRILKEVILAKKVSKVPINNVRAFPVLQTNYNGSIPVVRAQPGRKRKHKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTESVGGNK ------CCCCCCCCH | 36.65 | 19823750 | |
| 4 | Phosphorylation | ----MTESVGGNKLV ----CCCCCCCCHHH | 19.52 | 19823750 | |
| 19 | Phosphorylation | DFLVNVQSILNAASV HHHHCHHHHHHHHCC | 25.43 | 19823750 | |
| 25 | Phosphorylation | QSILNAASVKCHVVD HHHHHHHCCEEEECC | 21.50 | 19823750 | |
| 59 | Phosphorylation | CKFIKNRSNSEGLIR HHHHHCCCCCCCCCC | 54.85 | 19823750 | |
| 61 | Phosphorylation | FIKNRSNSEGLIRNE HHHCCCCCCCCCCCC | 34.00 | 27214570 | |
| 85 | Phosphorylation | KRFENGEYEPIQGGF HHHCCCCEEECCCCH | 28.53 | 28889911 | |
| 93 | Phosphorylation | EPIQGGFYKLYHDIK EECCCCHHHHHHHHH | 11.89 | 28889911 | |
| 127 | Phosphorylation | VDKFYKFSSELLLRE HHHHHHHCHHHHHHH | 20.81 | 29688323 | |
| 128 | Phosphorylation | DKFYKFSSELLLREC HHHHHHCHHHHHHHH | 35.08 | 29688323 | |
| 154 | Acetylation | NIKSRSGKLLSGNEM CCCCCCCCCCCCCCC | 47.72 | 24489116 | |
| 200 | Acetylation | QTYQIRTKDMDLFSS CEEEEEECCHHHHHH | 41.00 | 24489116 | |
| 322 | Sumoylation | GYMDLYEKNEKKVKQ CCHHHHHHCHHHHCH | 57.77 | - | |
| 328 | Sumoylation | EKNEKKVKQEELLNT HHCHHHHCHHHHCCC | 61.95 | - | |
| 356 | Phosphorylation | NKNVDGKSNGVQDDG CCCCCCCCCCCCCCC | 44.33 | 27017623 | |
| 374 | Phosphorylation | DNDATIASANSESTE CHHCCCEECCCCCCC | 24.92 | 23749301 | |
| 377 | Phosphorylation | ATIASANSESTENKE CCCEECCCCCCCCHH | 32.42 | 23749301 | |
| 437 | Ubiquitination | RKERILNKVLKPTTE HHHHHHHHHCCCCHH | 45.56 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RSC58_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RSC58_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RSC58_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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